PMID- 33133788
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201103
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 12
IP  - 10
DP  - 2020 Oct 23
TI  - Rectal Cancer Complicated by Acute Promyelocytic Leukemia.
PG  - e11118
LID - 10.7759/cureus.11118 [doi]
LID - e11118
AB  - Globally colorectal cancer is one of the leading causes of mortality among men. 
      Treatment modalities of chemotherapy and radiotherapy may put a risk in 
      developing therapy related myeloid leukemia (TRML). TRML has been reported with 
      Oxaliplatin, Capecitabine, and radiation therapy, which may consequently lead to 
      DNA damage, causing a secondary disease. Acute Promyelocytic Leukemia (APL) is a 
      type of TRML that occurs as a result of such therapies. We present a case of a 30 
      year old male who presented as a case of colorectal cancer. Subsequently, the 
      patient received Capecitabine with radiotherapy followed by abdominoperineal 
      resection. He received four additional cycles of XELOX protocol of chemotherapy. 
      Months later, he returned with an intestinal obstruction and a picture of TRML. 
      After a bone marrow biopsy, fluorescence in situ hybridization (FISH) and 
      cytogenetics evaluation, the diagnosis of APL was confirmed. All-trans retinoic 
      acid (ATRA) therapy was initiated with excellent response. In conclusion, TRML in 
      the form of APL needs to be diagnosed early and treated as a medical emergency to 
      prevent the high mortality rate associated with the disease.
CI  - Copyright (c) 2020, Alkhayyat et al.
FAU - Alkhayyat, Shadi
AU  - Alkhayyat S
AD  - Internal Medicine, King Abdulaziz University, Jeddah, SAU.
LA  - eng
PT  - Case Reports
DEP - 20201023
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC7586350
OTO - NOTNLM
OT  - acute promyelocytic leukemia
OT  - colorectal cancer
OT  - secondary
OT  - therapy related myeloid leukemia
OT  - xelox
COIS- The authors have declared that no competing interests exist.
EDAT- 2020/11/03 06:00
MHDA- 2020/11/03 06:01
PMCR- 2020/10/23
CRDT- 2020/11/02 06:18
PHST- 2020/11/02 06:18 [entrez]
PHST- 2020/11/03 06:00 [pubmed]
PHST- 2020/11/03 06:01 [medline]
PHST- 2020/10/23 00:00 [pmc-release]
AID - 10.7759/cureus.11118 [doi]
PST - epublish
SO  - Cureus. 2020 Oct 23;12(10):e11118. doi: 10.7759/cureus.11118.