PMID- 33136696
OWN - NLM
STAT- MEDLINE
DCOM- 20211227
LR  - 20240215
IS  - 1536-7355 (Electronic)
IS  - 1076-1608 (Print)
IS  - 1076-1608 (Linking)
VI  - 28
IP  - 1
DP  - 2022 Jan 1
TI  - Health-Related Quality of Life in Patients With ANCA-Associated Vasculitis and 
      Sinonasal Involvement: A Single-Center Cross-Sectional Study.
PG  - e89-e94
LID - 10.1097/RHU.0000000000001630 [doi]
AB  - BACKGROUND/OBJECTIVE: The aim of this study was to assess the impact of sinonasal 
      morbidity on quality of life (QoL) in antineutrophil cytoplasmic 
      antibody-associated vasculitis (AAV). METHODS: This cross-sectional case-control 
      study enrolled 71 patients-44 AAV cases with (ear, nose, and throat [ENT]-AAV) or 
      without ENT involvement (non-ENT-AAV) undergoing multidisciplinary evaluations 
      and 27 chronic rhinosinusitis (CRS) cases. Three validated QoL questionnaires 
      (Sino-Nasal Outcomes Test-22 [SNOT-22], Nasal Obstruction Symptom Evaluation 
      [NOSE], and Short-Form 36) were administered, and the 3 groups were compared. 
      RESULTS: The ENT-AAV patients were significantly younger (p = 0.01), with less 
      antineutrophil cytoplasmic antibody positivity frequency (p = 0.035) and lower 
      renal involvement (p = 0.003) than the non-ENT-AAV patients.The SNOT-22 
      questionnaire demonstrated significantly greater sinonasal morbidity in ENT-AAV 
      patients compared with CRS patients (p < 0.001). The NOSE score of ENT-AAV 
      patients was comparable to those of CRS patients, but higher than that of 
      non-ENT-AAV patients (p < 0.001). The SNOT-22 and NOSE scores positively 
      correlated with disease activity (p = 0.037; p = 0.004, respectively). Short-Form 
      36 domain-by-domain analysis revealed a significantly poorer QoL in ENT-AAV 
      patients, especially with physical functioning being progressively impaired in 
      CRS, non-ENT-AAV, and ENT-AAV patients (p < 0.001). No significant differences in 
      QoL came to light when AAV patients were stratified according to current systemic 
      o local treatments. CONCLUSIONS: The QoL in AAV patients is significantly 
      reduced, especially in the presence of ENT involvement. The AAV-related nasal 
      morbidity is consistent and comparable to that reported by CRS patients. It 
      significantly affects patients' QoL and in particular social functioning, leading 
      to limitation in daily/work activities. Organ-focused questionnaires and 
      multidisciplinary management are warranted to pursue a treat-to-target approach 
      in these patients.
CI  - Copyright (c) 2020 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Cazzador, Diego
AU  - Cazzador D
FAU - Padoan, Roberto
AU  - Padoan R
AD  - Rheumatology Unit, Department of Medicine DIMED, University of Padua, Padua, 
      Italy.
FAU - Colangeli, Roberta
AU  - Colangeli R
AD  - From the Otorhinolaryngology Unit.
FAU - Pendolino, Alfonso Luca
AU  - Pendolino AL
AD  - From the Otorhinolaryngology Unit.
FAU - Felicetti, Mara
AU  - Felicetti M
AD  - Rheumatology Unit, Department of Medicine DIMED, University of Padua, Padua, 
      Italy.
FAU - Zanoletti, Elisabetta
AU  - Zanoletti E
AD  - From the Otorhinolaryngology Unit.
FAU - Emanuelli, Enzo
AU  - Emanuelli E
AD  - From the Otorhinolaryngology Unit.
FAU - Martini, Alessandro
AU  - Martini A
AD  - From the Otorhinolaryngology Unit.
FAU - Doria, Andrea
AU  - Doria A
AD  - Rheumatology Unit, Department of Medicine DIMED, University of Padua, Padua, 
      Italy.
FAU - Nicolai, Piero
AU  - Nicolai P
AD  - From the Otorhinolaryngology Unit.
FAU - Schiavon, Franco
AU  - Schiavon F
AD  - Rheumatology Unit, Department of Medicine DIMED, University of Padua, Padua, 
      Italy.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Rheumatol
JT  - Journal of clinical rheumatology : practical reports on rheumatic & 
      musculoskeletal diseases
JID - 9518034
SB  - IM
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Quality of Life
MH  - *Sinusitis
PMC - PMC10836782
COIS- The authors declare no conflict of interest.
EDAT- 2020/11/03 06:00
MHDA- 2021/12/28 06:00
PMCR- 2024/02/02
CRDT- 2020/11/02 17:12
PHST- 2020/11/03 06:00 [pubmed]
PHST- 2021/12/28 06:00 [medline]
PHST- 2020/11/02 17:12 [entrez]
PHST- 2024/02/02 00:00 [pmc-release]
AID - 00124743-202201000-00027 [pii]
AID - RHU51378 [pii]
AID - 10.1097/RHU.0000000000001630 [doi]
PST - ppublish
SO  - J Clin Rheumatol. 2022 Jan 1;28(1):e89-e94. doi: 10.1097/RHU.0000000000001630.