PMID- 33137409
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20220531
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 451
DP  - 2020 Dec 15
TI  - Microglia-Astrocyte Cross Talk through IL-18/IL-18R Signaling Modulates 
      Migraine-like Behavior in Experimental Models of Migraine.
PG  - 207-215
LID - S0306-4522(20)30677-1 [pii]
LID - 10.1016/j.neuroscience.2020.10.019 [doi]
AB  - Interleukin-18 (IL-18) is an important regulator of innate and immune responses, 
      and is involved in the pain process, including neuropathic and cancer pain. The 
      current study demonstrated that inflammatory soup (IS) dural infusions elicited 
      the activation of microglia and astrocytes. In comparison, IS dural infusions 
      induced the upregulation of IL-18 and IL-18R in microglia and astrocytes, 
      respectively. Blocking the IL-18 signaling pathway attenuated nociceptive 
      behavior. In comparison, blocking IL-18 signaling also suppressed the activation 
      of astrocytes and nuclear factor-kappa B (NF-kappaB). IL-18 dural infusions induced 
      nociceptive behavior and glia activation. IL-18 is a product of the activation of 
      microglial toll-like receptor 4 (TLR4), and it acted on IL-18R expressed in 
      astrocytes. Subsequently, it stimulated the activation of nuclear factor-kappa B 
      (NF-kappaB), leading to the activation of astrocytes. In conclusion, IL-18-mediated 
      microglia/astrocyte interactions in the medullary dorsal horn likely contribute 
      to the development of hyperpathia or allodynia induced by migraines.
CI  - Copyright (c) 2020 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Gong, Qiaoyu
AU  - Gong Q
AD  - Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei 
      Province, China.
FAU - Lin, Yao
AU  - Lin Y
AD  - Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei 
      Province, China.
FAU - Lu, Zuneng
AU  - Lu Z
AD  - Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei 
      Province, China. Electronic address: lzn196480@126.com.
FAU - Xiao, Zheman
AU  - Xiao Z
AD  - Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei 
      Province, China. Electronic address: zmxiao@whu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201031
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Interleukin-18)
RN  - 0 (NF-kappa B)
RN  - 0 (Receptors, Interleukin-18)
SB  - IM
MH  - Animals
MH  - Astrocytes/metabolism
MH  - Interleukin-18/*metabolism
MH  - *Microglia/metabolism
MH  - *Migraine Disorders
MH  - Models, Theoretical
MH  - NF-kappa B/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Interleukin-18/*metabolism
MH  - Signal Transduction
OTO - NOTNLM
OT  - IL-18
OT  - NF-kappaB
OT  - TLR4
OT  - astrocyte
OT  - microglia
OT  - migraine
EDAT- 2020/11/03 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/11/02 20:11
PHST- 2020/06/10 00:00 [received]
PHST- 2020/10/12 00:00 [revised]
PHST- 2020/10/13 00:00 [accepted]
PHST- 2020/11/03 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/11/02 20:11 [entrez]
AID - S0306-4522(20)30677-1 [pii]
AID - 10.1016/j.neuroscience.2020.10.019 [doi]
PST - ppublish
SO  - Neuroscience. 2020 Dec 15;451:207-215. doi: 10.1016/j.neuroscience.2020.10.019. 
      Epub 2020 Oct 31.