PMID- 33137990
OWN - NLM
STAT- MEDLINE
DCOM- 20210329
LR  - 20210329
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 21
DP  - 2020 Oct 29
TI  - Blood Profile of Cytokines, Chemokines, Growth Factors, and Redox Biomarkers in 
      Response to Different Protocols of Treadmill Running in Rats.
LID - 10.3390/ijms21218071 [doi]
LID - 8071
AB  - Both positive and negative aspects of sport performance are currently considered. 
      The aim of our study was to determine time- and intensity-dependent effects of a 
      single exercise bout on redox and inflammatory status. The experiment was 
      performed on 40 male Wistar rats subjected to treadmill running for 30 min with 
      the speed of 18 m/min (M30) or 28 m/min (F30), or for 2 h with the speed of 18 
      m/min (M120). Immunoenzymatic and spectrophotometric methods were applied to 
      assess the levels of pro-inflammatory and anti-inflammatory cytokines, 
      chemokines, growth factors, the antioxidant barrier, redox status, oxidative 
      damage products, nitrosative stress, and their relationships with plasma 
      non-esterified fatty acids. Treadmill running caused a reduction in the content 
      of monocyte chemoattractant protein-1 (MCP1) and nitric oxide (M30, M120, F30 
      groups) as well as macrophage inflammatory protein-1alpha (MIP-1alpha) and regulated on 
      activation, normal T-cell expressed and secreted (RANTES) (M30, F30 groups). We 
      also demonstrated an increase in catalase activity as well as higher levels of 
      reduced glutathione, advanced oxidation protein products, lipid hydroperoxides, 
      malondialdehyde (M30, M120, F30 groups), and advanced glycation end products (F30 
      group). The presented findings showed the activation of antioxidative defense in 
      response to increased reactive oxygen species' production after a single bout of 
      exercise, but it did not prevent oxidative damage of macromolecules.
FAU - Supruniuk, Elzbieta
AU  - Supruniuk E
AUID- ORCID: 0000-0002-3595-4707
AD  - Department of Physiology, Medical University of Bialystok, 2C Mickiewicza Street, 
      15-222 Bialystok, Poland.
FAU - Maciejczyk, Mateusz
AU  - Maciejczyk M
AUID- ORCID: 0000-0001-5609-3187
AD  - Department of Hygiene, Epidemiology and Ergonomics, Medical University of 
      Bialystok, 2C Mickiewicza Street, 15-233 Bialystok, Poland.
FAU - Zalewska, Anna
AU  - Zalewska A
AUID- ORCID: 0000-0003-4562-0951
AD  - Experimental Dentistry Laboratory, Medical University of Bialystok, 24a M. 
      Sklodowskiej-Curie Street, 15-274 Bialystok, Poland.
FAU - Gorski, Jan
AU  - Gorski J
AD  - Department of Medical Sciences, Lomza State University of Applied Sciences, 
      18-400 Lomza, Poland.
FAU - Chabowski, Adrian
AU  - Chabowski A
AUID- ORCID: 0000-0002-7407-8156
AD  - Department of Physiology, Medical University of Bialystok, 2C Mickiewicza Street, 
      15-222 Bialystok, Poland.
LA  - eng
GR  - SUB/1/DN/19/005/1118/Uniwersytet Medyczny w Bialymstoku/
GR  - SUB/1/DN/20/011/1118/Uniwersytet Medyczny w Bialymstoku/
PT  - Journal Article
DEP - 20201029
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
SB  - IM
MH  - Animals
MH  - Antioxidants/*metabolism
MH  - Biomarkers/*blood
MH  - Chemokines/*blood
MH  - Cytokines/*blood
MH  - Exercise Test
MH  - Intercellular Signaling Peptides and Proteins/*blood
MH  - Male
MH  - Oxidation-Reduction
MH  - Oxidative Stress
MH  - *Physical Conditioning, Animal
MH  - Rats
MH  - Rats, Wistar
PMC - PMC7663152
OTO - NOTNLM
OT  - chemokines
OT  - cytokines
OT  - exercise
OT  - inflammation
OT  - oxidative stress
COIS- The authors declare no conflict of interest.
EDAT- 2020/11/04 06:00
MHDA- 2021/03/30 06:00
PMCR- 2020/11/01
CRDT- 2020/11/03 01:02
PHST- 2020/09/28 00:00 [received]
PHST- 2020/10/19 00:00 [revised]
PHST- 2020/10/27 00:00 [accepted]
PHST- 2020/11/03 01:02 [entrez]
PHST- 2020/11/04 06:00 [pubmed]
PHST- 2021/03/30 06:00 [medline]
PHST- 2020/11/01 00:00 [pmc-release]
AID - ijms21218071 [pii]
AID - ijms-21-08071 [pii]
AID - 10.3390/ijms21218071 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Oct 29;21(21):8071. doi: 10.3390/ijms21218071.