PMID- 33138008
OWN - NLM
STAT- MEDLINE
DCOM- 20210719
LR  - 20210719
IS  - 2073-4425 (Electronic)
IS  - 2073-4425 (Linking)
VI  - 11
IP  - 11
DP  - 2020 Oct 29
TI  - Strong Correlation between HLA and Clinical Course of Subacute Thyroiditis-A 
      Report of the Three Siblings.
LID - 10.3390/genes11111282 [doi]
LID - 1282
AB  - Subacute thyroiditis (SAT) is a thyroid inflammatory disease with susceptibility 
      associated with the presence of human leukocyte antigen (HLA)-B*35, -B*18:01, 
      -DRB1*01 and -C*04:01. Previous viral infection is considered as a triggering 
      factor in genetically predisposed individuals. The influence of HLA on the SAT 
      course was previously suggested. We aim to present the three siblings-female 
      twins and their brother-with very close onset but different clinical courses of 
      SAT, which appeared to be HLA-dependent. The HLA profile in the reported three 
      siblings is strongly correlated with both SAT and Graves' disease (GD), however 
      the coexistence of particular sets of high risk and protective alleles seems to 
      be crucial for the GD development and the SAT course. The co-occurrence of 
      HLA-DRB1*15:01 and/or -B*07:02, possibly together with the lack of HLA-A*01:01 
      and -B*41:01 seems to be key factors protecting against the development of GD 
      with high TRAb levels, as well as against the recurrent SAT course and steroid 
      dependence.
FAU - Stasiak, Magdalena
AU  - Stasiak M
AUID- ORCID: 0000-0002-2910-7691
AD  - Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial 
      Hospital-Research Institute, 93-338 Lodz, Poland.
FAU - Lewinski, Andrzej
AU  - Lewinski A
AUID- ORCID: 0000-0002-8748-3337
AD  - Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial 
      Hospital-Research Institute, 93-338 Lodz, Poland.
AD  - Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, 
      93-338 Lodz, Poland.
LA  - eng
PT  - Case Reports
PT  - Research Support, Non-U.S. Gov't
DEP - 20201029
PL  - Switzerland
TA  - Genes (Basel)
JT  - Genes
JID - 101551097
RN  - 0 (Autoantibodies)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-B*07 antigen)
RN  - 0 (HLA-B7 Antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*15:01 antigen)
RN  - 0 (Receptors, Thyrotropin)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Autoantibodies/blood
MH  - Diseases in Twins/genetics/immunology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Graves Disease/genetics/immunology
MH  - HLA Antigens/*genetics
MH  - HLA-B7 Antigen/genetics
MH  - HLA-DRB1 Chains/genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Receptors, Thyrotropin/immunology
MH  - Thyroiditis, Subacute/*genetics/*immunology
PMC - PMC7693567
OTO - NOTNLM
OT  - Graves' disease
OT  - human leukocyte antigen (HLA)
OT  - recurrence
OT  - subacute thyroiditis
COIS- The authors declare no conflict of interest.
EDAT- 2020/11/04 06:00
MHDA- 2021/07/20 06:00
PMCR- 2020/11/01
CRDT- 2020/11/03 01:02
PHST- 2020/10/03 00:00 [received]
PHST- 2020/10/17 00:00 [revised]
PHST- 2020/10/26 00:00 [accepted]
PHST- 2020/11/03 01:02 [entrez]
PHST- 2020/11/04 06:00 [pubmed]
PHST- 2021/07/20 06:00 [medline]
PHST- 2020/11/01 00:00 [pmc-release]
AID - genes11111282 [pii]
AID - genes-11-01282 [pii]
AID - 10.3390/genes11111282 [doi]
PST - epublish
SO  - Genes (Basel). 2020 Oct 29;11(11):1282. doi: 10.3390/genes11111282.