PMID- 33139983
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201104
IS  - 2186-3644 (Print)
IS  - 2186-361X (Electronic)
IS  - 2186-3644 (Linking)
VI  - 9
IP  - 4
DP  - 2020 Nov
TI  - Primary neuroendocrine carcinoma of the breast: a rare presentation and review of 
      the literature.
PG  - 233-246
LID - 10.5582/irdr.2020.03046 [doi]
AB  - Primary neuroendocrine carcinoma of the breast (NEBC) is a very rare occurrence 
      accounting for less than 0.1% of all breast cancers. Typically, the tumor 
      presents with ER- and PgR-positive and HER-2-negative status. Despite its luminal 
      type, NEBC is associated with a more aggressive clinical course and poorer 
      prognosis compared to the other types of invasive breast cancer. Clinical and 
      radiological findings are nonspecific. The most common clinical manifestation is 
      a palpable mass whereas in mammography the tumor most commonly appears as a round 
      or oval mass without spiculated margins. Herein, a very rare case of NEBC is 
      described in an asymptomatic patient who presented with an area of architectural 
      distortion and the presence of microcalcifications that was incidentally detected 
      on a screening mammography. A review of the literature has also been conducted. 
      The diagnosis of NEBC requires a thorough investigation to exclude the 
      possibility of a metastatic neuroendocrine tumor from another site because the 
      two entities require different treatment approaches. Due to the rarity of the 
      disease, the optimal therapeutic approach has not been clearly defined. Surgical 
      resection is the mainstay of treatment. Further research is needed to better 
      understand the molecular characteristics of NEBC and identify novel targeted 
      therapies.
CI  - 2020, International Research and Cooperation Association for Bio & Socio - 
      Sciences Advancement.
FAU - Salemis, Nikolaos S
AU  - Salemis NS
AD  - Breast Cancer Surgery Unit, Army General Hospital, Athens, Greece.
AD  - IASO Women's Hospital, Athens, Greece.
LA  - eng
PT  - Case Reports
PL  - Japan
TA  - Intractable Rare Dis Res
JT  - Intractable & rare diseases research
JID - 101586847
PMC - PMC7586876
OTO - NOTNLM
OT  - breast
OT  - carcinoma
OT  - neuroendocrine
EDAT- 2020/11/04 06:00
MHDA- 2020/11/04 06:01
PMCR- 2020/11/01
CRDT- 2020/11/03 05:47
PHST- 2020/11/03 05:47 [entrez]
PHST- 2020/11/04 06:00 [pubmed]
PHST- 2020/11/04 06:01 [medline]
PHST- 2020/11/01 00:00 [pmc-release]
AID - 10.5582/irdr.2020.03046 [doi]
PST - ppublish
SO  - Intractable Rare Dis Res. 2020 Nov;9(4):233-246. doi: 10.5582/irdr.2020.03046.