PMID- 33140026
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201104
IS  - 2364-3722 (Print)
IS  - 2196-9736 (Electronic)
IS  - 2196-9736 (Linking)
VI  - 8
IP  - 11
DP  - 2020 Nov
TI  - Safety and efficacy of endoscopic ultrasound-guided gastroenterostomy using 
      double balloon occlusion methods: a clinical retrospective study in 36 patients 
      with malignant gastric outlet obstruction.
PG  - E1690-E1697
LID - 10.1055/a-1221-9656 [doi]
AB  - Background and study aims  Gastric outlet obstruction (GOO) is common in the late 
      stage of many malignant tumors of the digestive system. Endoscopic ultrasound 
      (EUS)-guided gastroenterostomy (EUS-GE) is commonly used for palliative treatment 
      of malignant GOO. The objective of this study was to investigate the safety, 
      efficacy, and prognosis of EUS-GE in treatment of malignant GOO in Chinese 
      patients. Patients and methods  This was a retrospective, single-center study 
      with 36 consecutive patients with malignant GOO who were treated with EUS-GE. The 
      main outcome measures were technical success rate, clinical success rate, 
      incidence of adverse events (AEs), and median survival time. Results  A total of 
      36 patients with malignant GOO underwent double-balloon-assisted EUS-GE between 
      March 2017 and June 2019 in our hospital. GOO occurred mainly in elderly men 
      (mean age 69.0 years, M:F 0.89). The most common etiology of GOO was pancreatic 
      cancer (41.7 %). The most common obstruction site was the second part of the 
      duodenum (63.9 %). The technical success rate was 100 % (36/36). The clinical 
      success rate was 94.4 % (34/36). Median time for the total procedure was 52 
      minutes (range 34 - 156 min). Median time for determination of puncture site was 
      20 minutes (range 15 - 28 min). Median time between puncture and successful 
      delivery of the stent was 38 minutes (range 19 - 128 min). The GOOSS score was 
      0.2 before EUS-GE. The GOO Scoring System (GOOSS) score was 2.2 at 15 days after 
      the EUS-GE ( P  = 0.001). The GOOSS score was still higher than 2 during a median 
      follow-up period of 89 days. AEs were observed in nine patients (25.0 %) and 13 
      total AEs occurred. One patient died as a result of delayed stent migration and 
      bleeding. Mean length of hospital stay was 5.8 +/- 4.7 days. The median survival 
      period was 103 days. The rate of GOO recurrence was 2.7 % (1/36). Conclusion 
       EUS-GE was associated with increased safety and efficacy for treatment of 
      malignant GOO in Chinese Mainland.
CI  - The Author(s). This is an open access article published by Thieme under the terms 
      of the Creative Commons Attribution-NonDerivative-NonCommercial License, 
      permitting copying and reproduction so long as the original work is given 
      appropriate credit. Contents may not be used for commecial purposes, or adapted, 
      remixed, transformed or built upon. 
      (https://creativecommons.org/licenses/by-nc-nd/4.0/).
FAU - Xu, Guifang
AU  - Xu G
AD  - Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing 
      University Medical School.
FAU - Shen, Yonghua
AU  - Shen Y
AD  - Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing 
      University Medical School.
FAU - Lv, Ying
AU  - Lv Y
AD  - Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing 
      University Medical School.
FAU - Zhou, Xiaoliang
AU  - Zhou X
AD  - Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing 
      University Medical School.
FAU - Li, Wen
AU  - Li W
AD  - Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing 
      University Medical School.
FAU - Wang, Yi
AU  - Wang Y
AD  - Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing 
      University Medical School.
FAU - Hassan, Shahzeb
AU  - Hassan S
AD  - Northwestern University Feinberg School of Medicine, Chicago 60611, IL, United 
      States.
FAU - Wang, Lei
AU  - Wang L
AD  - Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing 
      University Medical School.
FAU - Zou, Xiaoping
AU  - Zou X
AD  - Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing 
      University Medical School.
LA  - eng
PT  - Journal Article
DEP - 20201022
PL  - Germany
TA  - Endosc Int Open
JT  - Endoscopy international open
JID - 101639919
PMC - PMC7581485
COIS- Competing interests The authors declare that they have no conflict of interest.
EDAT- 2020/11/04 06:00
MHDA- 2020/11/04 06:01
PMCR- 2020/11/01
CRDT- 2020/11/03 05:47
PHST- 2019/12/10 00:00 [received]
PHST- 2020/06/30 00:00 [accepted]
PHST- 2020/11/03 05:47 [entrez]
PHST- 2020/11/04 06:00 [pubmed]
PHST- 2020/11/04 06:01 [medline]
PHST- 2020/11/01 00:00 [pmc-release]
AID - 10.1055/a-1221-9656 [doi]
PST - ppublish
SO  - Endosc Int Open. 2020 Nov;8(11):E1690-E1697. doi: 10.1055/a-1221-9656. Epub 2020 
      Oct 22.