PMID- 33140265
OWN - NLM
STAT- MEDLINE
DCOM- 20220117
LR  - 20220117
IS  - 1936-0568 (Electronic)
IS  - 1936-055X (Print)
IS  - 1936-055X (Linking)
VI  - 15
IP  - 3
DP  - 2021 Sep
TI  - Epstein-Barr Virus-Associated Langerhans Cell Histiocytosis of the Thyroid Gland.
PG  - 1054-1058
LID - 10.1007/s12105-020-01247-8 [doi]
AB  - Thyroid gland involvement of Langerhans cell histiocytosis (LCH) is extremely 
      rare in both systemic and isolated disease. The role of viral infection in LCH 
      development is not yet fully understood. Although several viruses are proposed as 
      etiologic factors, such as Epstein-Barr virus (EBV) and human herpesvirus 6 
      (HHV-6), they seem to play a bystander role in LCH. A 29-year old female patient 
      with a prior history of multisystemic LCH (pituitary gland and skull bone), 
      presented with a thyroid nodule. The patient underwent a total thyroidectomy and 
      the histological examination revealed nodular lesions composed of sheets and 
      clusters of histiocytes in the inflammatory background. The histiocytes stained 
      positive for S-100 and CD1a and were negative for HHV-8, cytomegalovirus, and VE1 
      (anti-BRAF(V600E)) on immunohistochemistry. The EBER in situ hybridization for 
      EBV showed frequent positive-stained cells. The conventional PCR analysis for EBV 
      was positive and qPCR analysis confirmed a significant DNA copy number difference 
      (p = 0.02) between the tumor and adjacent non-neoplastic thyroid tissue. PCR 
      analysis for HHV-6, HPV, HSV was negative in both tumor and benign samples. In 
      conclusion, the presented case showed a rare thyroid involvement by LCH 
      associated with EBV infection, which has not been reported before. Further 
      studies are required to investigate a possible etiologic link between EBV 
      infection and LCH.
CI  - (c) 2020. Springer Science+Business Media, LLC, part of Springer Nature.
FAU - Munkhdelger, Jijgee
AU  - Munkhdelger J
AUID- ORCID: 0000-0003-3483-2342
AD  - Department of Pathology, Kameda Medical Center, 929 Higashi-cho, Kamogawa, Chiba, 
      296-8602, Japan.
FAU - Vatanasapt, Patravoot
AU  - Vatanasapt P
AUID- ORCID: 0000-0001-6037-8994
AD  - Department of Otorhinolaryngology, Faculty of Medicine, Khon Kaen University, 
      Khon Kaen, 40002, Thailand.
AD  - HPV and EBV Carcinogenesis Research Group, Khon Kaen University, 40002, Khon 
      Kaen, Thailand.
FAU - Pientong, Chamsai
AU  - Pientong C
AUID- ORCID: 0000-0003-2797-043X
AD  - HPV and EBV Carcinogenesis Research Group, Khon Kaen University, 40002, Khon 
      Kaen, Thailand.
AD  - Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      40002, Thailand.
FAU - Keelawat, Somboon
AU  - Keelawat S
AUID- ORCID: 0000-0002-4180-7914
AD  - Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, 
      10330, Thailand.
FAU - Bychkov, Andrey
AU  - Bychkov A
AUID- ORCID: 0000-0002-4203-5696
AD  - Department of Pathology, Kameda Medical Center, 929 Higashi-cho, Kamogawa, Chiba, 
      296-8602, Japan. bychkov.andrey@kameda.jp.
AD  - Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, 
      10330, Thailand. bychkov.andrey@kameda.jp.
AD  - Department of Pathology, Nagasaki University Graduate School of Biomedical 
      Sciences, Nagasaki, 852-8523, Japan. bychkov.andrey@kameda.jp.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20201102
PL  - United States
TA  - Head Neck Pathol
JT  - Head and neck pathology
JID - 101304010
SB  - IM
MH  - Adult
MH  - Epstein-Barr Virus Infections/*complications
MH  - Female
MH  - Histiocytosis, Langerhans-Cell/*pathology/*virology
MH  - Humans
MH  - Thyroid Diseases/*pathology/*virology
PMC - PMC8385082
OTO - NOTNLM
OT  - Epstein-Barr virus
OT  - Langerhans cell histiocytosis
OT  - Thyroid
COIS- The authors declare that there is no conflict of interest.
EDAT- 2020/11/04 06:00
MHDA- 2022/01/18 06:00
PMCR- 2021/11/02
CRDT- 2020/11/03 05:49
PHST- 2020/07/30 00:00 [received]
PHST- 2020/10/26 00:00 [accepted]
PHST- 2020/11/04 06:00 [pubmed]
PHST- 2022/01/18 06:00 [medline]
PHST- 2020/11/03 05:49 [entrez]
PHST- 2021/11/02 00:00 [pmc-release]
AID - 10.1007/s12105-020-01247-8 [pii]
AID - 1247 [pii]
AID - 10.1007/s12105-020-01247-8 [doi]
PST - ppublish
SO  - Head Neck Pathol. 2021 Sep;15(3):1054-1058. doi: 10.1007/s12105-020-01247-8. Epub 
      2020 Nov 2.