PMID- 33140902
OWN - NLM
STAT- MEDLINE
DCOM- 20210625
LR  - 20210625
IS  - 1939-1676 (Electronic)
IS  - 0891-6640 (Print)
IS  - 0891-6640 (Linking)
VI  - 34
IP  - 6
DP  - 2020 Nov
TI  - Serum immunoglobulin E responses to aeroallergens in cats with naturally 
      occurring airway eosinophilia compared to unaffected control cats.
PG  - 2671-2676
LID - 10.1111/jvim.15951 [doi]
AB  - BACKGROUND: Eosinophilic airway disease in cats is sometimes described as 
      allergic in origin, but controversy exists in the documentation of allergy in 
      cats and the utility of allergy testing for respiratory tract diseases. 
      OBJECTIVE: To examine serum immunoglobulin E (IgE) response to aeroallergens in 
      cats with airway eosinophilia. ANIMALS: Fifteen cats with idiopathic eosinophilic 
      airway inflammation and 9 control cats. METHODS: Prospective, case-control study. 
      Surplus serum from cats with airway eosinophilia documented by bronchoscopic 
      bronchoalveolar lavage was submitted for IgE measurement using ELISA polyclonal 
      antibody methodology. Responses for regional allergens (fungal organisms, weeds, 
      grasses, trees, mites, insects) were assessed. Results were reported as ELISA 
      absorbance units with scores 0 to 79 considered negative, scores between 80 and 
      300 considered intermediate, and scores >300 considered positive. RESULTS: Cats 
      with airway eosinophilia had significantly more positive serum IgE responses 
      (25/720) than did healthy controls (5/432, P = .02); however, the number of cats 
      with positive IgE responses (5/15) did not differ from controls (1/9, P = .35). 
      The allergen that most commonly resulted in positive serum IgE response in cats 
      with airway eosinophilia was dust mite (n = 4) followed by 2 types of storage 
      mites (n = 3 each). No control cat tested positive for these allergens. 
      CONCLUSIONS AND CLINICAL IMPORTANCE: Serum IgE production against aeroallergens 
      was found in some cats with eosinophilic airway inflammation, but the number of 
      affected cats with positive results did not differ from controls. Further 
      investigation in cats with eosinophilic, mixed, and neutrophilic airway disease 
      in comparison to control cats is warranted.
CI  - (c) 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley 
      Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
FAU - Buller, Maggie C
AU  - Buller MC
AD  - William R. Pritchard Veterinary Medical Teaching Hospital, University of 
      California School of Veterinary Medicine, Davis, California, USA.
FAU - Johnson, Lynelle R
AU  - Johnson LR
AUID- ORCID: 0000-0002-5331-5626
AD  - Department of Medicine and Epidemiology, University of California School of 
      Veterinary Medicine, Davis, California, USA.
FAU - Outerbridge, Catherine A
AU  - Outerbridge CA
AD  - Department of Medicine and Epidemiology, University of California School of 
      Veterinary Medicine, Davis, California, USA.
FAU - Vernau, William
AU  - Vernau W
AD  - Department of Pathology, Microbiology and Immunology, University of California 
      School of Veterinary Medicine, Davis, California, USA.
FAU - White, Stephen D
AU  - White SD
AD  - Department of Medicine and Epidemiology, University of California School of 
      Veterinary Medicine, Davis, California, USA.
LA  - eng
GR  - Bailey Wrigley Fund, University of California, Davis/
PT  - Journal Article
DEP - 20201103
PL  - United States
TA  - J Vet Intern Med
JT  - Journal of veterinary internal medicine
JID - 8708660
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens
MH  - Animals
MH  - *Asthma/veterinary
MH  - Case-Control Studies
MH  - *Cat Diseases
MH  - Cats
MH  - *Eosinophilia/veterinary
MH  - Immunoglobulin E
MH  - Prospective Studies
PMC - PMC7694819
OTO - NOTNLM
OT  - ELISA
OT  - asthma
OT  - bronchitis
OT  - bronchoscopy
OT  - immunology
COIS- Authors declare no conflict of interest.
EDAT- 2020/11/04 06:00
MHDA- 2021/06/29 06:00
PMCR- 2020/11/01
CRDT- 2020/11/03 08:40
PHST- 2020/06/15 00:00 [received]
PHST- 2020/10/16 00:00 [revised]
PHST- 2020/10/19 00:00 [accepted]
PHST- 2020/11/04 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2020/11/03 08:40 [entrez]
PHST- 2020/11/01 00:00 [pmc-release]
AID - JVIM15951 [pii]
AID - 10.1111/jvim.15951 [doi]
PST - ppublish
SO  - J Vet Intern Med. 2020 Nov;34(6):2671-2676. doi: 10.1111/jvim.15951. Epub 2020 
      Nov 3.