PMID- 33140904
OWN - NLM
STAT- MEDLINE
DCOM- 20220204
LR  - 20231213
IS  - 1755-148X (Electronic)
IS  - 1755-1471 (Linking)
VI  - 34
IP  - 5
DP  - 2021 Sep
TI  - Connexins in melanoma: Potential role of Cx46 in its aggressiveness.
PG  - 853-868
LID - 10.1111/pcmr.12945 [doi]
AB  - Melanoma is the most aggressive skin cancer, and in metastatic advanced states, 
      it is completely refractory to chemotherapy. Therefore, it is relevant to 
      understand the molecular bases that rule their aggressiveness. Connexins (Cxs) 
      are proteins that under normal physiological conditions participate in 
      intercellular communication, via the exchange of signaling molecules between the 
      cytoplasm and extracellular milieu and the exchange of ions/second messengers 
      between the cytoplasm of contacting cells. These proteins have shown important 
      roles in cancer progression, chemo- and radiotherapy resistance, and metastasis. 
      Accordingly, Cx26 and Cx43 seem to play important roles in melanoma progression 
      and metastasis. On the other hand, Cx46 is typically expressed in the eye lens, 
      where it seems to be associated with oxidative stress protection in fiber lens 
      cells. However, in the last decade, Cx46 expression has been associated with 
      breast and brain cancers, due to its role in potentiation of both extracellular 
      vesicle release and cancer stem cell-like properties. In this review, we analyzed 
      a potential role of Cx46 as a new biomarker and therapeutic target in melanoma.
CI  - (c) 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Orellana, Viviana P
AU  - Orellana VP
AD  - Universidad del Desarrollo. Centro de Fisiologia Celular e Integrativa, Clinica 
      Alemana Facultad de Medicina, Santiago, Chile.
AD  - Universidad del Desarrollo. Programa de Comunicacion Celular en Cancer, Clinica 
      Alemana Facultad de Medicina, Santiago, Chile.
FAU - Tittarelli, Andres
AU  - Tittarelli A
AD  - Programa Institucional de Fomento a la Investigacion, Desarrollo e Innovacion 
      (PIDi), Universidad Tecnologica Metropolitana (UTEM), Santiago, Chile.
FAU - Retamal, Mauricio A
AU  - Retamal MA
AUID- ORCID: 0000-0003-2562-6686
AD  - Universidad del Desarrollo. Centro de Fisiologia Celular e Integrativa, Clinica 
      Alemana Facultad de Medicina, Santiago, Chile.
AD  - Universidad del Desarrollo. Programa de Comunicacion Celular en Cancer, Clinica 
      Alemana Facultad de Medicina, Santiago, Chile.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20201120
PL  - England
TA  - Pigment Cell Melanoma Res
JT  - Pigment cell & melanoma research
JID - 101318927
RN  - 0 (Connexins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (GJA3 protein, human)
SB  - IM
MH  - *Cell Communication
MH  - Connexins/genetics/*metabolism
MH  - Humans
MH  - Lens, Crystalline/metabolism/pathology
MH  - Melanoma/genetics/*metabolism/pathology
MH  - Neoplasm Proteins/genetics/*metabolism
OTO - NOTNLM
OT  - Cx46
OT  - connexins
OT  - gap junctions
OT  - melanocytes
OT  - melanoma
OT  - skin
EDAT- 2020/11/04 06:00
MHDA- 2022/02/05 06:00
CRDT- 2020/11/03 08:40
PHST- 2020/10/20 00:00 [revised]
PHST- 2020/09/07 00:00 [received]
PHST- 2020/10/27 00:00 [accepted]
PHST- 2020/11/04 06:00 [pubmed]
PHST- 2022/02/05 06:00 [medline]
PHST- 2020/11/03 08:40 [entrez]
AID - 10.1111/pcmr.12945 [doi]
PST - ppublish
SO  - Pigment Cell Melanoma Res. 2021 Sep;34(5):853-868. doi: 10.1111/pcmr.12945. Epub 
      2020 Nov 20.