PMID- 33140980
OWN - NLM
STAT- MEDLINE
DCOM- 20211015
LR  - 20211015
IS  - 1473-4877 (Electronic)
IS  - 0300-7995 (Linking)
VI  - 37
IP  - 3
DP  - 2021 Mar
TI  - Determinants and impact of physical impairment in patient-reported outcomes among 
      older patients with type 2 diabetes mellitus in Japan.
PG  - 393-402
LID - 10.1080/03007995.2020.1846170 [doi]
AB  - OBJECTIVE: To investigate the predictive factors associated with physical 
      impairment among older patients with type 2 diabetes mellitus (T2DM) in Japan and 
      to examine the potential impact of physical impairment on patient-reported health 
      outcomes in this population. METHODS: A cross-sectional analysis was conducted 
      using patient-reported data from the 2012-2014 Japan National Health and Wellness 
      Survey. Physical impairment was measured using the Physical Component Summary 
      (PCS) score of the Short-Form 36-Item Health Survey (SF-36) three-component model 
      (using Japanese norms). Older T2DM patients (>/=65 years old; n = 1511) were 
      dichotomized into physically impaired (PCS </= 25th percentile; n = 378) and 
      non-physically impaired (PCS > 25th percentile; n = 1133). Work productivity 
      (absenteeism, presenteeism and overall work impairment), activity impairment and 
      healthcare resource utilization were compared between these groups. RESULTS: Age, 
      female sex, low and high body mass index (BMI), diabetes-related complications, 
      cardiovascular events, unawareness of having hypoglycemic events in the past 
      3 months, and lack of regular exercise were significant factors associated with 
      physical impairment in multivariable analysis. The physically impaired group 
      reported significantly more regular outpatient visits (13.48 vs. 10.16, 
      respectively, p < .001), 1% or greater absenteeism (16.7% vs. 4.1%, p = .005), 
      greater presenteeism (27.8% vs. 12.2%, p = .001), overall work impairment (30.0% 
      vs. 13.0%, p = .001) and overall activity impairment (39.5% vs. 17.2%, p < .001) 
      than the non-physically-impaired group after adjusting for covariates. 
      CONCLUSIONS: This study identified age, BMI, diabetes-related comorbidities, 
      history of cardiovascular events and lack of exercise as key predictors 
      associated with physical impairment in older patients with T2DM in Japan, which 
      predicted low work productivity as well as activity impairment. This study 
      provides support that physical impairment in patients with T2DM may lead to low 
      work productivity and activity impairment. Supplemental data for this article is 
      available online at https://doi.org/10.1080/03007995.2020.1846170.
FAU - Araki, Atsushi
AU  - Araki A
AUID- ORCID: 0000-0001-9088-2841
AD  - Department of Diabetes, Metabolism and Endocrinology, Tokyo Metropolitan 
      Geriatric Hospital,Tokyo,Japan.
FAU - Umegaki, Hiroyuki
AU  - Umegaki H
AUID- ORCID: 0000-0003-2504-4133
AD  - Department of Geriatrics and Community Healthcare, Graduate School of Medicine, 
      University of Nagoya,Nagoya,Japan.
FAU - Sakurai, Takashi
AU  - Sakurai T
AUID- ORCID: 0000-0002-2369-3095
AD  - The Center for Comprehensive Care and Research on Demented Disorders, National 
      Center for Geriatrics and Gerontology,Obu,Japan.
FAU - Mizuno, Yuzo
AU  - Mizuno Y
AUID- ORCID: 0000-0003-0985-0231
AD  - Division of Diabetes & Endocrinology, Kanto Central Hospital,Tokyo,Japan.
FAU - Miyao, Mariko
AU  - Miyao M
AUID- ORCID: 0000-0002-2767-1723
AD  - Division of Diabetes & Endocrinology, Kanto Central Hospital,Tokyo,Japan.
FAU - Imori, Makoto
AU  - Imori M
AD  - Medicines Development Unit Japan, Eli Lilly Japan,Kobe,Japan.
FAU - Suzuki, Shuichi
AU  - Suzuki S
AUID- ORCID: 0000-0001-8922-7428
AD  - Medicines Development Unit Japan, Eli Lilly Japan,Kobe,Japan.
FAU - Cambron-Mellott, M Janelle
AU  - Cambron-Mellott MJ
AUID- ORCID: 0000-0003-0061-104X
AD  - Kantar Health,New York,NY,USA.
FAU - Yokote, Koutaro
AU  - Yokote K
AUID- ORCID: 0000-0003-3033-4813
AD  - Department of Endocrinology, Hematology and Gerontology, Chiba University 
      Graduate School of Medicine,Chiba,Japan.
FAU - Onuma, Tomio
AU  - Onuma T
AD  - Department of Medicine, Diabetology & Endocrinology, Juntendo Tokyo Koto 
      Geriatric Medical Center,Tokyo,Japan.
FAU - Yokono, Koichi
AU  - Yokono K
AD  - Kita-Harima Medical Center,Ono,Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201123
PL  - England
TA  - Curr Med Res Opin
JT  - Current medical research and opinion
JID - 0351014
SB  - IM
MH  - Absenteeism
MH  - Aged
MH  - Cost of Illness
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Efficiency
MH  - Female
MH  - Health Surveys
MH  - Humans
MH  - Infant
MH  - Japan/epidemiology
MH  - Patient Reported Outcome Measures
MH  - Quality of Life
OTO - NOTNLM
OT  - Physical impairment
OT  - activity impairment
OT  - healthcare resource utilization
OT  - older adults
OT  - type 2 diabetes mellitus
OT  - work productivity
EDAT- 2020/11/04 06:00
MHDA- 2021/10/16 06:00
CRDT- 2020/11/03 12:19
PHST- 2020/11/04 06:00 [pubmed]
PHST- 2021/10/16 06:00 [medline]
PHST- 2020/11/03 12:19 [entrez]
AID - 10.1080/03007995.2020.1846170 [doi]
PST - ppublish
SO  - Curr Med Res Opin. 2021 Mar;37(3):393-402. doi: 10.1080/03007995.2020.1846170. 
      Epub 2020 Nov 23.