PMID- 33141999
OWN - NLM
STAT- MEDLINE
DCOM- 20220322
LR  - 20220322
IS  - 1098-2396 (Electronic)
IS  - 0887-4476 (Linking)
VI  - 75
IP  - 6
DP  - 2021 Jun
TI  - The C-terminal fragment of the heavy chain of the tetanus toxin (Hc-TeTx) 
      improves motor activity and neuronal morphology in the limbic system of aged 
      mice.
PG  - e22193
LID - 10.1002/syn.22193 [doi]
AB  - In the aging process, the brain presents biochemical and morphological 
      alterations. The neurons of the limbic system show reduced size dendrites, in 
      addition to the loss of dendritic spines. These disturbances trigger a decrease 
      in motor and cognitive function. Likewise, it is reported that during aging, in 
      the brain, there is a significant decrease in neurotrophic factors, which are 
      essential in promoting the survival and plasticity of neurons. The 
      carboxyl-terminal fragment of the heavy chain of the tetanus toxin (Hc-TeTx) acts 
      similarly to neurotrophic factors, inducing neuroprotection in different models 
      of neuronal damage. The aim here, was to evaluate the effect of Hc-TeTx on the 
      motor processes of elderly mice (18 months old), and its impact on the dendritic 
      morphology and density of dendritic spines of neurons in the limbic system. The 
      morphological analysis in the dendrites was evaluated employing Golgi-Cox 
      staining. Hc-TeTx was administered (0.5 mg/kg) intraperitoneally for three days 
      in 18-month-old mice. Locomotor activity was evaluated in a novel environment 
      30 days after the last administration of Hc-TeTx. Mice treated with Hc-TeTx 
      showed significant changes in their motor behavior, and an increased dendritic 
      spine density of pyramidal neurons in layers 3 and 5 of the prefrontal cortex in 
      the hippocampus, and medium spiny neurons of the nucleus accumbens (NAcc). In 
      conclusion, the Hc-TeTx improves the plasticity of the brain regions of the 
      limbic system of aged mice. Therefore, it is proposed as a pharmacological 
      alternative to prevent or delay brain damage during aging.
CI  - (c) 2020 Wiley Periodicals, Inc.
FAU - Vazquez-Roque, Ruben
AU  - Vazquez-Roque R
AUID- ORCID: 0000-0002-2712-5714
AD  - Neuropsychiatry Laboratory, Institute of Physiology, Benemerita Universidad 
      Autonoma de Puebla, Puebla, Mexico.
FAU - Pacheco-Flores, Mariana
AU  - Pacheco-Flores M
AD  - Department of Psychology, Universidad De Las Americas Puebla, Puebla, Mexico.
FAU - Penagos-Corzo, Julio Cesar
AU  - Penagos-Corzo JC
AUID- ORCID: 0000-0002-4879-3033
AD  - Department of Psychology, Universidad De Las Americas Puebla, Puebla, Mexico.
FAU - Flores, Gonzalo
AU  - Flores G
AUID- ORCID: 0000-0002-4100-2104
AD  - Neuropsychiatry Laboratory, Institute of Physiology, Benemerita Universidad 
      Autonoma de Puebla, Puebla, Mexico.
FAU - Aguilera, Jose
AU  - Aguilera J
AD  - Department of Biochemistry and Molecular Biology, Faculty of Medicine, Institut 
      de Neurociencies, Universitat Autonoma de Barcelona, Cerdanyola del Valles, 
      Barcelona, Spain.
AD  - Networked Biomedical Research Center on Neurodegenerative Diseases (CIBERNED), 
      Barcelona, Spain.
FAU - Trevino, Samuel
AU  - Trevino S
AUID- ORCID: 0000-0001-5679-1671
AD  - Faculty of Chemical Sciences, Benemerita Universidad Autonoma de Puebla, Puebla, 
      Mexico.
FAU - Guevara, Jorge
AU  - Guevara J
AUID- ORCID: 0000-0003-3428-3179
AD  - Department of Biochemistry, Faculty of Medicine, National Autonomous University 
      of Mexico, Mexico City, Mexico.
FAU - Diaz, Alfonso
AU  - Diaz A
AUID- ORCID: 0000-0003-4092-6636
AD  - Faculty of Chemical Sciences, Benemerita Universidad Autonoma de Puebla, Puebla, 
      Mexico.
FAU - Venegas, Berenice
AU  - Venegas B
AUID- ORCID: 0000-0001-9009-655X
AD  - Faculty of Biological Sciences, Benemerita Universidad Autonoma de Puebla, 
      Puebla, Mexico.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201122
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - 0 (Tetanus Toxin)
SB  - IM
MH  - Animals
MH  - Dendrites/metabolism
MH  - Hippocampus/metabolism
MH  - Limbic System/metabolism
MH  - Mice
MH  - Motor Activity
MH  - *Neurons/metabolism
MH  - *Tetanus Toxin/metabolism/pharmacology/therapeutic use
OTO - NOTNLM
OT  - carboxil-terminal fragment of heavy chain of tetanus toxin
OT  - dendritic spines
OT  - golgi-cox staining
OT  - locomotor activity
OT  - nucleus accumbens
EDAT- 2020/11/04 06:00
MHDA- 2022/03/23 06:00
CRDT- 2020/11/03 17:13
PHST- 2020/10/24 00:00 [revised]
PHST- 2020/06/16 00:00 [received]
PHST- 2020/10/27 00:00 [accepted]
PHST- 2020/11/04 06:00 [pubmed]
PHST- 2022/03/23 06:00 [medline]
PHST- 2020/11/03 17:13 [entrez]
AID - 10.1002/syn.22193 [doi]
PST - ppublish
SO  - Synapse. 2021 Jun;75(6):e22193. doi: 10.1002/syn.22193. Epub 2020 Nov 22.