PMID- 33142598
OWN - NLM
STAT- MEDLINE
DCOM- 20210409
LR  - 20210409
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 251
DP  - 2021 Jan 1
TI  - A facile injectable carbon dot/oxidative polysaccharide hydrogel with potent 
      self-healing and high antibacterial activity.
PG  - 117040
LID - S0144-8617(20)31213-3 [pii]
LID - 10.1016/j.carbpol.2020.117040 [doi]
AB  - Bacterial infection is one of the most formidable problems in wound healing, 
      which inflicts severe pain on patients while causing wound ulceration. Here, we 
      prepared an injectable self-healing carbon dot hydrogel with outstanding 
      antibacterial activity only using epsilon-poly(L-lysine) carbon dot (PL-CD) and 
      oxidized dextran (ODA). The particle size of PL-CD prepared by pyrolysis of 
      poly-l-lysine was about 3 nm. Moreover, PL-CD with abundant -NH(2) on its surface 
      could not only act as nodes to connect ODA through Schiff base to construct 
      PL-CD@ODA hydrogel network, but also offer excellent antibacterial properties. As 
      the contacting and releasing antibacterial action of the PL-CD@ODA hydrogel, 
      nearly 100 % of the 10(7) CFU/mL of S. aureus was killed after 10 min of 
      contacting. In addition, PL-CD@ODA hydrogel showed flexible injectability and 
      extremely strong self-healing properties after being severely damaged. When 1000 
      % shear stress applied to the hydrogel, complete healing could be achieved within 
      a few seconds.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Yang, Xu
AU  - Yang X
AD  - School of Chemical Engineering, Nanjing University of Science and Technology, 
      Nanjing 210094, China.
FAU - Li, Peili
AU  - Li P
AD  - School of Chemical Engineering, Nanjing University of Science and Technology, 
      Nanjing 210094, China.
FAU - Tang, Wentao
AU  - Tang W
AD  - School of Chemical Engineering, Nanjing University of Science and Technology, 
      Nanjing 210094, China.
FAU - Du, Shoukang
AU  - Du S
AD  - School of Materials Science and Engineering, Nanjing University of Science and 
      Technology, Nanjing 210094, China.
FAU - Yu, Meizhe
AU  - Yu M
AD  - School of Chemical Engineering, Nanjing University of Science and Technology, 
      Nanjing 210094, China.
FAU - Lu, Haojie
AU  - Lu H
AD  - School of Chemical Engineering, Nanjing University of Science and Technology, 
      Nanjing 210094, China.
FAU - Tan, Huaping
AU  - Tan H
AD  - School of Materials Science and Engineering, Nanjing University of Science and 
      Technology, Nanjing 210094, China.
FAU - Xing, Xiaodong
AU  - Xing X
AD  - School of Chemical Engineering, Nanjing University of Science and Technology, 
      Nanjing 210094, China. Electronic address: xingxiaodong07@njust.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20200906
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Dextrans)
RN  - 0 (Hydrogels)
RN  - 0 (poly(lysine)-graft-dextran)
RN  - 25104-18-1 (Polylysine)
RN  - 7440-44-0 (Carbon)
SB  - IM
MH  - Anti-Bacterial Agents/*chemistry/pharmacology
MH  - Bacterial Infections/therapy
MH  - *Carbon/chemistry/pharmacology
MH  - *Dextrans/chemistry/pharmacology
MH  - Humans
MH  - *Hydrogels/chemistry/pharmacology
MH  - Nanoparticles/*chemistry
MH  - Polylysine/*analogs & derivatives/chemistry/pharmacology
MH  - Staphylococcus aureus/drug effects
MH  - Wound Healing/*drug effects
OTO - NOTNLM
OT  - Antibacterial
OT  - Carbon dots
OT  - Hydrogel
OT  - Injectable
OT  - Self-healing
EDAT- 2020/11/05 06:00
MHDA- 2021/04/10 06:00
CRDT- 2020/11/04 01:01
PHST- 2020/07/21 00:00 [received]
PHST- 2020/08/31 00:00 [revised]
PHST- 2020/08/31 00:00 [accepted]
PHST- 2020/11/04 01:01 [entrez]
PHST- 2020/11/05 06:00 [pubmed]
PHST- 2021/04/10 06:00 [medline]
AID - S0144-8617(20)31213-3 [pii]
AID - 10.1016/j.carbpol.2020.117040 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2021 Jan 1;251:117040. doi: 10.1016/j.carbpol.2020.117040. Epub 
      2020 Sep 6.