PMID- 33143144
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201128
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 9
IP  - 11
DP  - 2020 Oct 30
TI  - Effects of Pirfenidone and Nintedanib on Markers of Systemic Oxidative Stress and 
      Inflammation in Patients with Idiopathic Pulmonary Fibrosis: A Preliminary 
      Report.
LID - 10.3390/antiox9111064 [doi]
LID - 1064
AB  - INTRODUCTION: In vitro evidence suggests that pirfenidone and nintedanib, 
      approved agents for the treatment of idiopathic pulmonary fibrosis (IPF), exert 
      anti-inflammatory and anti-oxidant effects. We aimed to investigate such effects 
      in vivo in IPF patients. METHODS: Systemic circulating markers of oxidative 
      stress [nuclear factor erythroid 2-related factor 2 (Nrf2), thiobarbituric acid- 
      reactive substances (TBARS), homocysteine (Hcy), cysteine (Cys), asymmetric 
      dimethylarginine (ADMA) and ADMA/Arginine ratio, glutathione (GSH), plasma 
      protein -SH (PSH), and taurine (Tau)] and inflammation [Kynurenine (Kyn), 
      Tryptophan (Trp) and Kyn/Trp ratio] were measured at baseline and after 24-week 
      treatment in 18 IPF patients (10 treated with pirfenidone and 8 with nintedanib) 
      and in 18 age- and sex-matched healthy controls. RESULTS: Compared to controls, 
      IPF patients had significantly lower concentrations of reduced blood GSH (457 +/- 
      73 micromol/L vs 880 +/- 212 micromol/L, p < 0.001) and plasma PSH (4.24 +/- 0.95 micromol/g prot 
      vs 5.28 +/- 1.35 micromol/g prot, p = 0.012). Pirfenidone treatment significantly 
      decreased the Kyn/Trp ratio (0.030 +/- 0.011 baseline vs 0.025 +/- 0.010 
      post-treatment, p = 0.048) whilst nintedanib treatment significantly increased 
      blood GSH (486 +/- 70 mumol/L vs 723 +/- 194 mumol/L, p = 0.006) and reduced ADMA 
      concentrations (0.501 +/- 0.094 vs. 0.468 +/- 0.071 mumol/L, p = 0.024). CONCLUSION: 
      pirfenidone and nintedanib exert beneficial effects on specific markers of 
      oxidative stress and inflammation in IPF patients.
FAU - Fois, Alessandro G
AU  - Fois AG
AD  - Department of Medical, Surgical and Experimental Sciences, University of Sassari, 
      07100 Sassari, Italy.
FAU - Sotgiu, Elisabetta
AU  - Sotgiu E
AD  - Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
FAU - Scano, Valentina
AU  - Scano V
AD  - Department of Medical, Surgical and Experimental Sciences, University of Sassari, 
      07100 Sassari, Italy.
FAU - Negri, Silvia
AU  - Negri S
AD  - Department of Medical, Surgical and Experimental Sciences, University of Sassari, 
      07100 Sassari, Italy.
FAU - Mellino, Sabrina
AU  - Mellino S
AD  - Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
FAU - Zinellu, Elisabetta
AU  - Zinellu E
AD  - Unit of Respiratory Diseases, University Hospital Sassari (AOU), 07100 Sassari, 
      Italy.
FAU - Pirina, Pietro
AU  - Pirina P
AUID- ORCID: 0000-0003-1457-8025
AD  - Department of Medical, Surgical and Experimental Sciences, University of Sassari, 
      07100 Sassari, Italy.
FAU - Pintus, Gianfranco
AU  - Pintus G
AUID- ORCID: 0000-0002-3031-7733
AD  - Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
AD  - Department of Medical Laboratory Sciences, College of Health Sciences and Sharjah 
      Institute for Medical Research, University of Sharjah, Sharjah P.O Box 27272, 
      UAE.
FAU - Carru, Ciriaco
AU  - Carru C
AUID- ORCID: 0000-0002-6985-4907
AD  - Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
FAU - Mangoni, Arduino A
AU  - Mangoni AA
AUID- ORCID: 0000-0001-8699-1412
AD  - Department of Clinical Pharmacology, College of Medicine and Public Health, 
      Flinders University and Flinders Medical Centre, Adelaide 5100, Australia.
FAU - Zinellu, Angelo
AU  - Zinellu A
AUID- ORCID: 0000-0002-8396-0968
AD  - Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
LA  - eng
GR  - RASSR82005/Regione Autonoma della Sardegna/
PT  - Journal Article
DEP - 20201030
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC7692317
OTO - NOTNLM
OT  - idiopathic pulmonary fibrosis
OT  - inflammation
OT  - nintedanib
OT  - oxidative stress
OT  - pirfenidone
COIS- The authors declare no conflict of interest.
EDAT- 2020/11/05 06:00
MHDA- 2020/11/05 06:01
PMCR- 2020/10/30
CRDT- 2020/11/04 01:03
PHST- 2020/09/14 00:00 [received]
PHST- 2020/10/18 00:00 [revised]
PHST- 2020/10/28 00:00 [accepted]
PHST- 2020/11/04 01:03 [entrez]
PHST- 2020/11/05 06:00 [pubmed]
PHST- 2020/11/05 06:01 [medline]
PHST- 2020/10/30 00:00 [pmc-release]
AID - antiox9111064 [pii]
AID - antioxidants-09-01064 [pii]
AID - 10.3390/antiox9111064 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2020 Oct 30;9(11):1064. doi: 10.3390/antiox9111064.