PMID- 33143214
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201128
IS  - 2076-3425 (Print)
IS  - 2076-3425 (Electronic)
IS  - 2076-3425 (Linking)
VI  - 10
IP  - 11
DP  - 2020 Oct 30
TI  - The Effect of Robot-Assisted Gait Training on Locomotor Function and Functional 
      Capability for Daily Activities in Children with Cerebral Palsy: A 
      Single-Blinded, Randomized Cross-Over Trial.
LID - 10.3390/brainsci10110801 [doi]
LID - 801
AB  - PURPOSE: The effectiveness of robot-assisted gait training (RAGT) in children 
      with cerebral palsy (CP), especially in terms of improving the performance of 
      daily activities, remains unclear. Therefore, we aimed to investigate the 
      effectiveness of RAGT in children with CP. METHODS: In this single-center, 
      single-blinded, randomized cross-over trial, we enrolled 20 children with CP with 
      Gross Motor Function Classification System (GMFCS) levels II-IV (13 males; age 
      range, 6.75 +/- 2.15 years). The participants were randomized into the 
      RAGT/standard care (SC) (n = 10) and SC/RAGT/SC sequence groups (n = 10). Using a 
      Walkbot-K system, the RAGT program comprised 3 x 30-min sessions/week for 6 weeks 
      with a continued SC program. The SC program comprised 2-4 conventional 
      physiotherapy sessions/week for 6 weeks. The Gross Motor Function Measure-88 
      (GMFM-88), the pediatric functional independence measure (WeeFIM), and the 
      Canadian occupational performance measure (COPM) scores were assessed pre- and 
      post-RAGT or SC periods and treatment, period, follow-up, and carry-over effects 
      were analyzed. Energy expenditure and body composition were measured pre- and 
      post-RAGT. RESULTS: Significant treatment effects were observed in dimensions D 
      and E of the GMFM (D: p = 0.018; E: p = 0.021) scores, WeeFIM mobility subtotal 
      (p = 0.007), and COPM performance (p < 0.001) and satisfaction (p = 0.001) 
      measure scores. The period, follow-up, and carry-over effects were not 
      statistically significant. The gross energy cost significantly decreased (p = 
      0.041) and the skeletal muscle mass increased (p = 0.014) at post-RAGT 
      assessment. The factors associated with functional outcomes showed significant 
      improvements in the GMFM D scores and were mainly observed in children with GMFCS 
      levels II-III compared to those classified at level IV (p = 0.038). CONCLUSION: 
      RAGT had training benefits for children with CP. Specifically, it improved 
      locomotor function and functional capability for daily activities. These effects 
      were better in ambulatory children with CP. However, as SC interventions 
      continued during the RAGT period, these improvements may be also related to 
      multiple treatment effects.
FAU - Jin, Li Hua
AU  - Jin LH
AUID- ORCID: 0000-0002-5406-8815
AD  - Department of Rehabilitation Medicine, School of Medicine, Chungnam National 
      University, Daejeon 35015, Korea.
FAU - Yang, Shin-Seung
AU  - Yang SS
AUID- ORCID: 0000-0002-6831-1556
AD  - Department of Rehabilitation Medicine, School of Medicine, Chungnam National 
      University, Daejeon 35015, Korea.
AD  - Department of Rehabilitation Medicine, Chungnam National University Hospital, 
      Daejeon 35015, Korea.
FAU - Choi, Ja Young
AU  - Choi JY
AD  - Department of Rehabilitation Medicine, Chungnam National University Hospital, 
      Daejeon 35015, Korea.
FAU - Sohn, Min Kyun
AU  - Sohn MK
AUID- ORCID: 0000-0002-2548-545X
AD  - Department of Rehabilitation Medicine, School of Medicine, Chungnam National 
      University, Daejeon 35015, Korea.
AD  - Department of Rehabilitation Medicine, Chungnam National University Hospital, 
      Daejeon 35015, Korea.
LA  - eng
GR  - NRCTR-EX18010/Translational Research Program for Rehabilitation Robots/
PT  - Journal Article
DEP - 20201030
PL  - Switzerland
TA  - Brain Sci
JT  - Brain sciences
JID - 101598646
PMC - PMC7693488
OTO - NOTNLM
OT  - cerebral palsy
OT  - gross motor function
OT  - robotic-assisted gait training
COIS- The authors declare no conflict of interest.
EDAT- 2020/11/05 06:00
MHDA- 2020/11/05 06:01
PMCR- 2020/11/01
CRDT- 2020/11/04 01:03
PHST- 2020/08/22 00:00 [received]
PHST- 2020/10/10 00:00 [revised]
PHST- 2020/10/26 00:00 [accepted]
PHST- 2020/11/04 01:03 [entrez]
PHST- 2020/11/05 06:00 [pubmed]
PHST- 2020/11/05 06:01 [medline]
PHST- 2020/11/01 00:00 [pmc-release]
AID - brainsci10110801 [pii]
AID - brainsci-10-00801 [pii]
AID - 10.3390/brainsci10110801 [doi]
PST - epublish
SO  - Brain Sci. 2020 Oct 30;10(11):801. doi: 10.3390/brainsci10110801.