PMID- 33143280 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201128 IS - 2079-6382 (Print) IS - 2079-6382 (Electronic) IS - 2079-6382 (Linking) VI - 9 IP - 11 DP - 2020 Oct 30 TI - Safety of Nurse- and Self-Administered Paediatric Outpatient Parenteral Antimicrobial Therapy. LID - 10.3390/antibiotics9110761 [doi] LID - 761 AB - This study aimed to compare and contrast the safety and efficacy of nurse- and self-administered paediatric outpatient parenteral antimicrobial therapy (OPAT) models of care and to identify clinical factors associated with documented adverse events (AEs). A total of 100 OPAT episodes among children aged between 1 month and 18 years who were discharged from hospital and who received continuous 24 h intravenous antimicrobial therapy at home via an elastomeric infusion device were included. All documented AEs from the case notes were reviewed by a paediatrician and classified as either major or minor. Multivariable logistic regression was used to determine associations between clinical factors and any AE. A total of 86 patients received 100 treatment OPAT episodes (49 self-administered, 51 nurse administered). The most commonly prescribed antimicrobial via continuous infusion was ceftazidime (25 episodes). Overall, an AE was recorded for 27 (27%) OPAT episodes. Major AEs was recorded for 15 episodes and minor AEs were reported in 14 episodes. The odds of an AE was increased in episodes with self-administration (adjusted odds ratio (aOR) 6.25, 95% confidence interval (CI) 1.44-27.15) and where the duration of vascular access was >14 days (aOR 1.08, 95%CI 1.01-1.15). Our findings suggest minor AEs may be more frequently reported when intravenous antimicrobials are self-administered via 24 h continuous infusions. FAU - Sriskandarajah, Shanthy AU - Sriskandarajah S AUID- ORCID: 0000-0003-1609-6433 AD - Medical Device Research Institute, College of Science and Engineering, Flinders University, GPO Box 2100, Adelaide 5001, South Australia, Australia. FAU - Ritchie, Brett AU - Ritchie B AD - Infectious Diseases Department, Women's and Children's Hospital, North Adelaide 5006, Australia. FAU - Sluggett, Janet K AU - Sluggett JK AUID- ORCID: 0000-0002-9059-5209 AD - UniSA Allied Health and Human Performance, University of South Australia, Adelaide 5000, Australia. AD - CPIE Pharmacy Services, Findon 5023, Australia. AD - Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia. FAU - Reynolds, Jodie G Hobbs And Karen J AU - Reynolds JGHAKJ AD - Medical Device Research Institute, College of Science and Engineering, Flinders University, GPO Box 2100, Adelaide 5001, South Australia, Australia. AD - Medical Device Research Institute, College of Science and Engineering, Flinders University, GPO Box 2100, Adelaide 5001, South Australia, Australia. LA - eng GR - N/A/South Australian Government Department of Further Education, Employment, Science and Technology/ PT - Journal Article DEP - 20201030 PL - Switzerland TA - Antibiotics (Basel) JT - Antibiotics (Basel, Switzerland) JID - 101637404 PMC - PMC7694010 OTO - NOTNLM OT - adverse events OT - children OT - infusion pumps OT - outpatient parenteral antimicrobial therapy OT - safety COIS- S.S., J.G.H. and K.J.R. report grants from Government of South Australia during the conduct of the study. B.R. has nothing to disclose. J.K.S. is funded by a National Health and Medical Research Council (NHMRC) Early Career Fellowship. J.K.S. is a shareholder in Infusion Innovations Pty Ltd., Adelaide, Australia, which was established to attract grant funding and conduct further studies in this field. Infusion Innovations Pty Ltd. has filed several infusion device patent applications. This was a retrospective audit and no equipment used in the present study was sourced from Infusion Innovations Pty Ltd. EDAT- 2020/11/05 06:00 MHDA- 2020/11/05 06:01 PMCR- 2020/10/30 CRDT- 2020/11/04 01:03 PHST- 2020/09/13 00:00 [received] PHST- 2020/10/15 00:00 [revised] PHST- 2020/10/29 00:00 [accepted] PHST- 2020/11/04 01:03 [entrez] PHST- 2020/11/05 06:00 [pubmed] PHST- 2020/11/05 06:01 [medline] PHST- 2020/10/30 00:00 [pmc-release] AID - antibiotics9110761 [pii] AID - antibiotics-09-00761 [pii] AID - 10.3390/antibiotics9110761 [doi] PST - epublish SO - Antibiotics (Basel). 2020 Oct 30;9(11):761. doi: 10.3390/antibiotics9110761.