PMID- 33144239
OWN - NLM
STAT- MEDLINE
DCOM- 20210602
LR  - 20210602
IS  - 1097-6779 (Electronic)
IS  - 0016-5107 (Linking)
VI  - 93
IP  - 6
DP  - 2021 Jun
TI  - Total motorized spiral enteroscopy: first prospective clinical feasibility trial.
PG  - 1362-1370
LID - S0016-5107(20)34934-8 [pii]
LID - 10.1016/j.gie.2020.10.028 [doi]
AB  - BACKGROUND AND AIMS: Motorized spiral enteroscopy (MSE) was recently introduced 
      into clinical practice and shown to be safe and effective for antegrade 
      enteroscopy. The aim of the current trial was to prospectively study the efficacy 
      and safety of MSE for visualization of the entire small bowel. METHODS: All 
      consecutive patients with indications for complete enteroscopy meeting the 
      inclusion criteria were enrolled in a prospective observational bicentric trial, 
      starting with antegrade MSE; a retrograde approach was performed if MSE remained 
      incomplete from antegrade. The primary objective was to ascertain the total 
      enteroscopy rate (TER); secondary objectives were diagnostic yield, procedural 
      success, time, depth of maximum insertion (DMI), therapeutic yield, and adverse 
      events (AEs). RESULTS: Thirty patients (16 women, 14 men; median age 64 years 
      [range, 37-100]) were enrolled. Technical success rate of antegrade MSE 
      (advancement beyond the ligament of Treitz) and retrograde MSE (advancement 
      beyond the ileocecal valve [ICV]) were 100% and 100%, respectively. Overall TER 
      was 70%: 16.6% antegrade approach alone and 53.4% bidirectional approach. Median 
      antegrade DMI distal from the ligament of Treitz was 490 cm (range, 160-600); 
      median insertion time 26 minutes (range, 15-110). The median retrograde DMI 
      beyond the ICV was 120 cm (range, 40-600), and median insertion time was 17 
      minutes (range, 1-68). Overall diagnostic and therapeutic yields were 80% and 
      86.7%, respectively. Overall AE rate was 16.7%. No serious AEs occurred. 
      CONCLUSIONS: This prospective study showed that complete enteroscopy is feasible 
      with MSE, either from antegrade alone or bidirectionally, with high success rates 
      and short procedural duration. These results justify further evaluation of MSE in 
      a large prospective multicenter study, preferably with inclusion of a control 
      group. (Clinical trial registration number: NCT03438695.).
CI  - Copyright (c) 2021 American Society for Gastrointestinal Endoscopy. Published by 
      Elsevier Inc. All rights reserved.
FAU - Beyna, Torsten
AU  - Beyna T
AD  - Department of Internal Medicine and Gastroenterology, Evangelisches Krankenhaus 
      Dusseldorf, Dusseldorf, Germany.
FAU - Arvanitakis, Marianna
AU  - Arvanitakis M
AD  - Department of Gastroenterology and Hepato-Pancreatology, Erasme Hospital, 
      Universite Libre des Bruxelles, Brussels, Belgium.
FAU - Schneider, Markus
AU  - Schneider M
AD  - Department of Internal Medicine and Gastroenterology, Evangelisches Krankenhaus 
      Dusseldorf, Dusseldorf, Germany.
FAU - Gerges, Christian
AU  - Gerges C
AD  - Department of Internal Medicine and Gastroenterology, Evangelisches Krankenhaus 
      Dusseldorf, Dusseldorf, Germany.
FAU - Hoellerich, Joerg
AU  - Hoellerich J
AD  - Department of Internal Medicine and Gastroenterology, Evangelisches Krankenhaus 
      Dusseldorf, Dusseldorf, Germany.
FAU - Deviere, Jacques
AU  - Deviere J
AD  - Department of Gastroenterology and Hepato-Pancreatology, Erasme Hospital, 
      Universite Libre des Bruxelles, Brussels, Belgium.
FAU - Neuhaus, Horst
AU  - Neuhaus H
AD  - Department of Internal Medicine and Gastroenterology, Evangelisches Krankenhaus 
      Dusseldorf, Dusseldorf, Germany.
LA  - eng
SI  - ClinicalTrials.gov/NCT03438695
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
DEP - 20201102
PL  - United States
TA  - Gastrointest Endosc
JT  - Gastrointestinal endoscopy
JID - 0010505
SB  - IM
CIN - Gastrointest Endosc. 2021 Jun;93(6):1371-1372. PMID: 33691976
MH  - Double-Balloon Enteroscopy
MH  - Endoscopy, Gastrointestinal
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - *Intestinal Diseases
MH  - Intestine, Small/diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
EDAT- 2020/11/05 06:00
MHDA- 2021/06/03 06:00
CRDT- 2020/11/04 05:35
PHST- 2020/08/31 00:00 [received]
PHST- 2020/10/17 00:00 [accepted]
PHST- 2020/11/05 06:00 [pubmed]
PHST- 2021/06/03 06:00 [medline]
PHST- 2020/11/04 05:35 [entrez]
AID - S0016-5107(20)34934-8 [pii]
AID - 10.1016/j.gie.2020.10.028 [doi]
PST - ppublish
SO  - Gastrointest Endosc. 2021 Jun;93(6):1362-1370. doi: 10.1016/j.gie.2020.10.028. 
      Epub 2020 Nov 2.