PMID- 33144793
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201105
IS  - 0976-3147 (Print)
IS  - 0976-3155 (Electronic)
IS  - 0976-3155 (Linking)
VI  - 11
IP  - 4
DP  - 2020 Oct
TI  - Association of Plasma Biomarkers for Angiogenesis and Proteinopathy in Indian 
      Amyotrophic Lateral Sclerosis Patients.
PG  - 573-580
LID - 10.1055/s-0040-1714314 [doi]
AB  - Background  Amyotrophic lateral sclerosis (ALS) is a rare motor neuron disease 
      with progressive degeneration of motor neurons. Various molecules have been 
      explored to provide the early diagnostic/prognostic tool for ALS without getting 
      much success in the field and miscellaneous reports studied in various 
      population. Objective  The study was aimed to see the differential expression of 
      proteins involved in angiogenesis (angiogenin [ANG], vascular endothelial growth 
      factor [VEGF], vascular endothelial growth factor receptor 2 [VEGFR2], etc), 
      proteinopathy (transactive response DNA binding protein-43 [TDP-43] and 
      optineurin [OPTN]), and neuroinflammation (monocyte chemoattractant 
      protein-1[MCP-1]) based on the characteristics of ALS pathology. Though, suitable 
      panel based on protein expression profile can be designed to robust the ALS 
      identification by enhancing the prognostic and diagnostic efficacy for ALS. 
      Methods  A total of 89 ALS patients and 98 nonneurological controls were analyzed 
      for the protein expression. Expression of angiogenic (VEGF, VEGFR2, and ANG), 
      neuroinflammation (MCP-1), and proteinopathy (TDP-43 and OPTN) markers were 
      estimated in plasma of the participants. Proteins were normalized with respective 
      value of total protein before employing statistical analysis. Results  Analysis 
      has exhibited significantly reduced expression of angiogenic, proteinopathy, and 
      neuroinflammation biomarkers in ALS patients in comparison to controls. 
      Spearman's correlation analysis has showed the positive correlation to each 
      protein. Conclusion  Altered expression of these proteins is indicating the 
      prominent function in ALS pathology which may be interdependent and may have a 
      synergistic role. Hence, a panel of expression can be proposed to diagnose ALS 
      patient which may also suggest the modulation of therapeutic strategy according 
      to expression profile of patient.
CI  - Association for Helping Neurosurgical Sick People. This is an open access article 
      published by Thieme under the terms of the Creative Commons 
      Attribution-NonDerivative-NonCommercial-License, permitting copying and 
      reproduction so long as the original work is given appropriate credit. Contents 
      may not be used for commercial purposes, or adapted, remixed, transformed or 
      built upon. https://creativecommons.org/licenses/by-nc-nd/4.0/.
FAU - Modgil, Shweta
AU  - Modgil S
AD  - Department of Neurology, Neuroscience Research Lab, Postgraduate Institute of 
      Medical Education and Research, Chandigarh, India.
FAU - Khosla, Radhika
AU  - Khosla R
AD  - Department of Neurology, Neuroscience Research Lab, Postgraduate Institute of 
      Medical Education and Research, Chandigarh, India.
FAU - Tiwari, Abha
AU  - Tiwari A
AD  - Department of Neurology, Neuroscience Research Lab, Postgraduate Institute of 
      Medical Education and Research, Chandigarh, India.
FAU - Sharma, Kaushal
AU  - Sharma K
AD  - Department of Neurology, Neuroscience Research Lab, Postgraduate Institute of 
      Medical Education and Research, Chandigarh, India.
FAU - Anand, Akshay
AU  - Anand A
AD  - Department of Neurology, Neuroscience Research Lab, Postgraduate Institute of 
      Medical Education and Research, Chandigarh, India.
LA  - eng
PT  - Journal Article
DEP - 20200820
PL  - United States
TA  - J Neurosci Rural Pract
JT  - Journal of neurosciences in rural practice
JID - 101533710
PMC - PMC7595776
OTO - NOTNLM
OT  - MCP-1/ CCL-2
OT  - TDP-43
OT  - amyotrophic lateral sclerosis
OT  - angiogenic markers (VEGF, VEGFR2, angiogenin)
OT  - optineurin
COIS- NoteAuthors' ContributionsConflict of Interest Each demographic factor is divided 
      into categories and the mean protein levels of markers were compared for the 
      respective categories. No significant difference was found between protein levels 
      with respect to various categories of these factors. S.M.: planning and execution 
      of experiments, data generation and analysis, writing, and editing of manuscript; 
      R.K.: experimentation, data generation and analysis, writing, and editing of 
      manuscript; A.T.: experimentation and data generation. K.S.: data analysis and 
      editing of manuscript; A.A.: corresponding author and editing of manuscript. None 
      declared.
EDAT- 2020/11/05 06:00
MHDA- 2020/11/05 06:01
PMCR- 2020/10/01
CRDT- 2020/11/04 05:42
PHST- 2020/11/04 05:42 [entrez]
PHST- 2020/11/05 06:00 [pubmed]
PHST- 2020/11/05 06:01 [medline]
PHST- 2020/10/01 00:00 [pmc-release]
AID - JNRP19100457 [pii]
AID - 10.1055/s-0040-1714314 [doi]
PST - ppublish
SO  - J Neurosci Rural Pract. 2020 Oct;11(4):573-580. doi: 10.1055/s-0040-1714314. Epub 
      2020 Aug 20.