PMID- 33144868
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220418
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2020
DP  - 2020
TI  - Herbal Formula Gegen-Qinlian Decoction for Type 2 Diabetes Mellitus: A 
      Meta-Analysis of Randomized Controlled Trials.
PG  - 3907920
LID - 10.1155/2020/3907920 [doi]
LID - 3907920
AB  - BACKGROUND: Herbal formula Gegen-Qinlian Decoction (GQD) has been widely used in 
      China for the treatment of type 2 diabetes mellitus (T2DM), but its efficacy and 
      safety are unclear. METHOD: The studies were identified from the PubMed, EMBASE, 
      Cochrane Library, China National Knowledge Infrastructure database, Wanfang 
      database, and VIP database using the keywords "Gegenqinlian" or "Gegen-Qinlian" 
      or "Gegen-Qin-Lian" or "Ge Gen Qin Lian." Relevant studies were selected 
      according to predefined inclusion and exclusion criteria. Study selection, data 
      extraction, and validation were carried out by, at least, two reviewers with 
      disagreements being settled by discussion. RESULTS: After literature search, a 
      total of 26 randomized controlled trials were included with a total of 2553 
      patients. There was evidence that compared with metformin, the combination of GQD 
      and metformin significantly reduced the fasting plasma glucose levels (MD -1.79, 
      95% CI (-2.31, -1.27), p < 0.00001); 2-hour postprandial plasma glucose levels 
      (MD -1.72, 95% CI (-2.12, -1.31), p < 0.00001); and glycosylated hemoglobin 
      levels (MD -1.26, 95% CI (-1.80, -0.72), p < 0.00001), and no serious side 
      effects were identified. CONCLUSION: These data suggest that GQD may be an 
      effective herbal formula in treating T2DM without serious side effects. The 
      addition of GQD also enhances the hypoglycemic effects of metformin. However, the 
      evidence remains weak due to methodological flaws, which may amplify the 
      therapeutic benefit of GQD.
CI  - Copyright (c) 2020 Lin Ren et al.
FAU - Ren, Lin
AU  - Ren L
AD  - Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, 
      China.
FAU - Cheng, Yanxia
AU  - Cheng Y
AD  - Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, 
      China.
FAU - Qin, Feng
AU  - Qin F
AUID- ORCID: 0000-0001-9521-7146
AD  - Andrology Laboratory, West China Hospital, Sichuan University, Chengdu 610041, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20201021
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC7596527
COIS- All authors declare that they have no conflicts of interest.
EDAT- 2020/11/05 06:00
MHDA- 2020/11/05 06:01
PMCR- 2020/10/21
CRDT- 2020/11/04 05:42
PHST- 2020/05/29 00:00 [received]
PHST- 2020/09/29 00:00 [revised]
PHST- 2020/10/07 00:00 [accepted]
PHST- 2020/11/04 05:42 [entrez]
PHST- 2020/11/05 06:00 [pubmed]
PHST- 2020/11/05 06:01 [medline]
PHST- 2020/10/21 00:00 [pmc-release]
AID - 10.1155/2020/3907920 [doi]
PST - epublish
SO  - Evid Based Complement Alternat Med. 2020 Oct 21;2020:3907920. doi: 
      10.1155/2020/3907920. eCollection 2020.