PMID- 33147000
OWN - NLM
STAT- MEDLINE
DCOM- 20210204
LR  - 20210204
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Linking)
VI  - 54
IP  - 22
DP  - 2020 Nov 17
TI  - Heterogeneous Ozonolysis of Tetrahydrocannabinol: Implications for Thirdhand 
      Cannabis Smoke.
PG  - 14215-14223
LID - 10.1021/acs.est.0c03728 [doi]
AB  - Thirdhand smoke (THS) deposits to surfaces following smoking events and is a 
      source of chemical exposure to humans. However, the evolution of THS in indoor 
      environments is not well understood. Cannabis THS is a chemically distinct and 
      prevalent form of THS, which has not been studied. The heterogeneous reaction of 
      Delta(9)-tetrahydrocannabinol (THC), a major component of cannabis smoke, with ozone 
      was examined as a pure compound and within cannabis smoke. Oxidative decay via 
      ozonolysis and product formation were monitored by liquid chromatography-tandem 
      mass spectrometry. Epoxide, dicarbonyl, and secondary ozonide THC reaction 
      products were detected from both pure THC and cannabis experiments, with the 
      product ratios dependent on relative humidity. The observed reaction kinetics for 
      loss of THC on glass and cotton surfaces are consistent with a relatively short 
      loss lifetime, which will be strongly dependent on the film thickness, ozone 
      mixing ratio, and ozone reactivity of the surface substrate. The low volatility 
      of THC and its oxidation products suggest that their contributions to thirdhand 
      cannabis smoke will be less significant than the role that nicotine plays in 
      thirdhand tobacco smoke.
FAU - Wylie, Aaron D L
AU  - Wylie ADL
AUID- ORCID: 0000-0001-5721-514X
AD  - Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON 
      M5S 3H6, Canada.
FAU - Abbatt, Jonathan P D
AU  - Abbatt JPD
AUID- ORCID: 0000-0002-3372-334X
AD  - Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON 
      M5S 3H6, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201104
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Smoke)
RN  - 0 (Tobacco Smoke Pollution)
RN  - 66H7ZZK23N (Ozone)
RN  - 7J8897W37S (Dronabinol)
SB  - IM
MH  - *Cannabis
MH  - Dronabinol
MH  - Humans
MH  - *Ozone
MH  - Smoke
MH  - *Tobacco Smoke Pollution/analysis
EDAT- 2020/11/05 06:00
MHDA- 2021/02/05 06:00
CRDT- 2020/11/04 17:10
PHST- 2020/11/05 06:00 [pubmed]
PHST- 2021/02/05 06:00 [medline]
PHST- 2020/11/04 17:10 [entrez]
AID - 10.1021/acs.est.0c03728 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2020 Nov 17;54(22):14215-14223. doi: 
      10.1021/acs.est.0c03728. Epub 2020 Nov 4.