PMID- 33149700
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231112
IS  - 1179-1411 (Print)
IS  - 1179-1411 (Electronic)
IS  - 1179-1411 (Linking)
VI  - 12
DP  - 2020
TI  - Incidence and Clinicopathological Features of Breast Cancer in the Northern 
      Emirates: Experience from Sharjah Breast Care Center.
PG  - 893-899
LID - 10.2147/IJWH.S266335 [doi]
AB  - BACKGROUND: Breast cancer is the most frequently reported cancer among women in 
      the Middle East and North Africa (MENA) region. However, the available data about 
      women breast cancer from the MENA and particularly from the Northern Emirates 
      region of the United Arab Emirates (UAE) are scarce and inconsistent. Therefore, 
      this study estimated the incidence, patient-specific factors including 25(OH)D 
      levels, and clinicopathological features of breast cancer in women from the 
      Northern Emirates. METHODS: We conducted this retrospective case-control study on 
      1,048 women who were referred to the Sharjah Breast Care Centre at University 
      Hospital Sharjah between March 2016 and July 2018. Multivariate logistic 
      regression was used for the statistical analysis of clinical data. RESULTS: Out 
      of 1048 women with breast-related conditions referred to our canter, 94 (10%) 
      were diagnosed with breast cancer (1 in 11), and approximately 1 in 5 of these 
      women was younger than 40 years. After adjusting for age, body mass index and 
      menopause status, women with serum 25-hydroxyvitamin D [25(OH)D] levels lower 
      than 20 ng/mL were found to be at higher risk of breast cancer (odd ratio, 4.63; 
      95% CI, 2.61-8.23). The majority of breast cancer cases had invasive-ductal 
      carcinoma with hormone-positive receptor molecular subtype (78 cases out of 94, 
      83%). HER2 overexpressing tumor (3+ by immunohistochemistry (IHC) or by 
      fluorescence in situ hybridization (FISH)) was seen more in women younger than 40 
      years as compared to older women (7 cases out of 19 HER2 expressed tumors, 
      p=0.007). CONCLUSION: Our study cohort showed a mean age of diagnosis of breast 
      cancer in women a decade earlier than in the developed countries. Furthermore, 
      women with breast cancer tend to be serum 25(OH)D deficient at diagnosis and to 
      have luminal A tumors.
CI  - (c) 2020 Bendardaf et al.
FAU - Bendardaf, Riyad
AU  - Bendardaf R
AUID- ORCID: 0000-0002-5158-4590
AD  - Oncology Unit, University Hospital Sharjah, Sharjah, United Arab Emirates.
AD  - Clinical Sciences Department, College of Medicine, University of Sharjah, 
      Sharjah, United Arab Emirates.
FAU - Saheb Sharif-Askari, Fatemeh
AU  - Saheb Sharif-Askari F
AUID- ORCID: 0000-0001-8498-055X
AD  - Sharjah Institute of Medical Research, College of Medicine, University of 
      Sharjah, Sharjah, United Arab Emirates.
FAU - Saheb Sharif-Askari, Narjes
AU  - Saheb Sharif-Askari N
AUID- ORCID: 0000-0003-0482-6777
AD  - Sharjah Institute of Medical Research, College of Medicine, University of 
      Sharjah, Sharjah, United Arab Emirates.
FAU - Yousuf Guraya, Salman
AU  - Yousuf Guraya S
AUID- ORCID: 0000-0001-5183-023X
AD  - Clinical Sciences Department, College of Medicine, University of Sharjah, 
      Sharjah, United Arab Emirates.
FAU - A AlMadhi, Sawsan
AU  - A AlMadhi S
AD  - The Pink Caravan, Friends of Cancer Patients Society, Sharjah, United Arab 
      Emirates.
FAU - Abusnana, Salah
AU  - Abusnana S
AUID- ORCID: 0000-0001-6546-8622
AD  - Clinical Sciences Department, College of Medicine, University of Sharjah, 
      Sharjah, United Arab Emirates.
AD  - Department of Diabetes and Endocrinology, University Hospital Sharjah, Sharjah, 
      United Arab Emirates.
LA  - eng
PT  - Journal Article
DEP - 20201027
PL  - New Zealand
TA  - Int J Womens Health
JT  - International journal of women's health
JID - 101531698
PMC - PMC7602912
OTO - NOTNLM
OT  - HER2 expression
OT  - Northern Emirates
OT  - breast cancer
OT  - luminal subtypes
OT  - serum 25(OH)D deficiency
COIS- The authors declare that there is no conflict of interest.
EDAT- 2020/11/06 06:00
MHDA- 2020/11/06 06:01
PMCR- 2020/10/27
CRDT- 2020/11/05 06:06
PHST- 2020/06/05 00:00 [received]
PHST- 2020/09/03 00:00 [accepted]
PHST- 2020/11/05 06:06 [entrez]
PHST- 2020/11/06 06:00 [pubmed]
PHST- 2020/11/06 06:01 [medline]
PHST- 2020/10/27 00:00 [pmc-release]
AID - 266335 [pii]
AID - 10.2147/IJWH.S266335 [doi]
PST - epublish
SO  - Int J Womens Health. 2020 Oct 27;12:893-899. doi: 10.2147/IJWH.S266335. 
      eCollection 2020.