PMID- 33149724
OWN - NLM
STAT- MEDLINE
DCOM- 20210927
LR  - 20221207
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2020
DP  - 2020
TI  - Association of Circulating Omentin-1 with Osteoporosis in a Chinese Type 2 
      Diabetic Population.
PG  - 9389720
LID - 10.1155/2020/9389720 [doi]
LID - 9389720
AB  - AIMS: Omentin-1, a newly identified adipokine, has been demonstrated to be 
      associated with bone metabolism, but the results have been inconsistent. 
      Moreover, the potential relationship of circulating omentin-1 with diabetic 
      osteoporosis has never been reported. This study is intended for studying the 
      association between circulating omentin-1, bone mineral density (BMD), prior 
      fragility fractures, and other bone metabolic-related parameters. METHODS: 
      Circulating omentin-1 levels were measured in 172 patients with type 2 diabetes 
      mellitus (T2DM), and participants were divided into the normal BMD group (n = 
      52), the osteopenia group (n = 66), and the osteoporosis group (n = 54). The 
      relationship between circulating omentin-1 and diabetic osteoporosis and other 
      parameters was analyzed. RESULTS: Circulating omentin-1 was significantly higher 
      in the osteoporosis group than in the normal group and in the osteopenia group 
      (both P < 0.05). Circulating omentin-1 levels were correlated significantly and 
      positively with sex; high-density lipoprotein cholesterol; apolipoprotein A; and 
      prevalence of prior fragility fractures, diabetic nephropathy, and retinopathy; 
      they were correlated negatively with diastolic blood pressure, triglyceride, 
      hemoglobin, atherogenic index of plasma, osteoporosis self-assessment tool for 
      Asians, BMD at different skeletal sites, and corresponding T scores, irrespective 
      of age, sex, and body mass index (P < 0.01 or P < 0.05). Moreover, circulating 
      omentin-1 was an independent decisive factor for the presence of osteoporosis 
      only in women after multivariate adjustment (odds ratio: 1.069; 95% confidence 
      interval: 1.003-1.139; P < 0.05). Lastly, the analysis of receiver operating 
      characteristic curves revealed that the best cutoff value for circulating 
      omentin-1 to predict diabetic osteoporosis was 15.37 ng/mL (sensitivity: 71.7%; 
      specificity: 58.5%) in female subjects. CONCLUSIONS: High levels of circulating 
      omentin-1 may be associated with the development of osteoporosis in female 
      diabetic subjects and may be a potential biomarker for diabetic osteoporosis in 
      women.
CI  - Copyright (c) 2020 Pijun Yan et al.
FAU - Yan, Pijun
AU  - Yan P
AUID- ORCID: 0000-0001-6692-2401
AD  - Department of Endocrinology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan 646000, China.
FAU - Xu, Yong
AU  - Xu Y
AUID- ORCID: 0000-0002-9534-6252
AD  - Department of Endocrinology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan 646000, China.
FAU - Zhang, Zhihong
AU  - Zhang Z
AUID- ORCID: 0000-0003-2415-8323
AD  - Department of General Medicine, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan 646000, China.
FAU - Zhu, Jianhua
AU  - Zhu J
AUID- ORCID: 0000-0002-9235-541X
AD  - Department of Endocrinology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan 646000, China.
FAU - Miao, Ying
AU  - Miao Y
AD  - Department of Endocrinology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan 646000, China.
FAU - Gao, Chenlin
AU  - Gao C
AUID- ORCID: 0000-0003-2464-9325
AD  - Department of Endocrinology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan 646000, China.
FAU - Wan, Qin
AU  - Wan Q
AUID- ORCID: 0000-0002-3498-0399
AD  - Department of Endocrinology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan 646000, China.
LA  - eng
PT  - Journal Article
DEP - 20201015
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (ITLN1 protein, human)
RN  - 0 (Lectins)
RN  - EC 3.1.3.2 (ACP5 protein, human)
RN  - EC 3.1.3.2 (Tartrate-Resistant Acid Phosphatase)
SB  - IM
MH  - Absorptiometry, Photon
MH  - Aged
MH  - Aged, 80 and over
MH  - Anthropometry
MH  - Asian People
MH  - Biomarkers/blood
MH  - Bone Density
MH  - Bone Diseases, Metabolic
MH  - Bone and Bones/metabolism
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Cytokines/*blood
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Female
MH  - GPI-Linked Proteins/blood
MH  - Humans
MH  - Inflammation
MH  - Lectins/*blood
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Osteoporosis/*blood/complications
MH  - ROC Curve
MH  - Tartrate-Resistant Acid Phosphatase/metabolism
PMC - PMC7603618
COIS- No potential conflicts of interest relevant to this article were reported.
EDAT- 2020/11/06 06:00
MHDA- 2021/09/28 06:00
PMCR- 2020/10/15
CRDT- 2020/11/05 06:06
PHST- 2020/05/15 00:00 [received]
PHST- 2020/07/26 00:00 [revised]
PHST- 2020/08/03 00:00 [accepted]
PHST- 2020/11/05 06:06 [entrez]
PHST- 2020/11/06 06:00 [pubmed]
PHST- 2021/09/28 06:00 [medline]
PHST- 2020/10/15 00:00 [pmc-release]
AID - 10.1155/2020/9389720 [doi]
PST - epublish
SO  - Mediators Inflamm. 2020 Oct 15;2020:9389720. doi: 10.1155/2020/9389720. 
      eCollection 2020.