PMID- 33149748
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201106
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2020
DP  - 2020
TI  - Dendrobium officinale Flower Extraction Mitigates Alcohol-Induced Liver Injury in 
      Mice: Role of Antisteatosis, Antioxidative, and Anti-Inflammatory.
PG  - 1421853
LID - 10.1155/2020/1421853 [doi]
LID - 1421853
AB  - The study aimed to evaluate the protective effect of Dendrobium officinale flower 
      extraction (DOFE) on alcohol-induced liver injury and its probable mechanisms in 
      mice. The chemical composition of DOFE was performed via UPLC/MS. Male Kunming 
      mice were used to establish alcohol-induced liver injury models by oral gavage of 
      56% alcohol. Results showed that DOFE dramatically attenuated the increased serum 
      levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total 
      cholesterol (TC), and triacylglycerol (TG). Meanwhile, hematoxylin and eosin and 
      Oil Red O staining showed that DOFE attenuated degeneration, inflammatory 
      infiltration, and lipid droplet accumulation. DOFE was also found to suppress the 
      activity of malonaldehyde (MDA) and enhanced the level of glutathione (GSH) and 
      the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), 
      and catalase (CAT) in the liver. The protection of DOFE against oxidative stress 
      was associated with the downregulation of hepatic cytochrome P450 2E1 (CYP2E1) 
      and upregulation of nuclear factor erythroid 2-related factor 2 (Nrf2), heme 
      oxygenase-1 (HO-1), and NAD(P)H quinone oxidoreductase l (NQO1). Additionally, 
      DOFE suppressed inflammation via downregulating Toll-like receptor-4 (TLR-4) and 
      nuclear factor kappa-B P65 (NF-kappaB P65). Thus, DOFE exhibited a significant 
      protective effect against alcohol-induced liver injury through its antisteatosis, 
      antioxidative, and anti-inflammatory effect.
CI  - Copyright (c) 2020 Yu-Lin Wu et al.
FAU - Wu, Yu-Lin
AU  - Wu YL
AD  - Guangdong Provincial Key Laboratory of New Drug Development and Research of 
      Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou 
      University of Chinese Medicine, Guangzhou 510000, China.
FAU - Huang, Si-Han
AU  - Huang SH
AD  - Medical College of Jiaying University, Jiaying University, Meizhou 514000, China.
FAU - He, Chun-Mei
AU  - He CM
AD  - Guangdong Provincial Key Laboratory of Silviculture, Protection and Utilization, 
      Guangdong Academy of Forestry, Guangzhou 510000, China.
FAU - Qiu, Bo
AU  - Qiu B
AD  - Medical College of Jiaying University, Jiaying University, Meizhou 514000, China.
FAU - Liu, Jing-Jing
AU  - Liu JJ
AD  - Guangdong Provincial Key Laboratory of New Drug Development and Research of 
      Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou 
      University of Chinese Medicine, Guangzhou 510000, China.
FAU - Li, Jia
AU  - Li J
AD  - Guangdong Provincial Key Laboratory of New Drug Development and Research of 
      Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou 
      University of Chinese Medicine, Guangzhou 510000, China.
FAU - Lin, Ying
AU  - Lin Y
AD  - School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, 
      Guangzhou 510000, China.
FAU - Yu, Sheng-Lu
AU  - Yu SL
AD  - Liannan Yao Autonomous County Xinshengtang Biological Technology Co., Ltd., 
      Qingyuan 511500, China.
FAU - Wang, Hong-Feng
AU  - Wang HF
AUID- ORCID: 0000-0001-8351-7504
AD  - Guangdong Provincial Key Laboratory of Silviculture, Protection and Utilization, 
      Guangdong Academy of Forestry, Guangzhou 510000, China.
FAU - Zhang, Gui-Fang
AU  - Zhang GF
AUID- ORCID: 0000-0002-9690-7226
AD  - Guangdong Provincial Key Laboratory of New Drug Development and Research of 
      Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou 
      University of Chinese Medicine, Guangzhou 510000, China.
LA  - eng
PT  - Journal Article
DEP - 20201014
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC7603571
COIS- The authors declare no conflicts of interest.
EDAT- 2020/11/06 06:00
MHDA- 2020/11/06 06:01
PMCR- 2020/10/14
CRDT- 2020/11/05 06:07
PHST- 2020/08/04 00:00 [received]
PHST- 2020/09/05 00:00 [revised]
PHST- 2020/09/30 00:00 [accepted]
PHST- 2020/11/05 06:07 [entrez]
PHST- 2020/11/06 06:00 [pubmed]
PHST- 2020/11/06 06:01 [medline]
PHST- 2020/10/14 00:00 [pmc-release]
AID - 10.1155/2020/1421853 [doi]
PST - epublish
SO  - Evid Based Complement Alternat Med. 2020 Oct 14;2020:1421853. doi: 
      10.1155/2020/1421853. eCollection 2020.