PMID- 33152632 OWN - NLM STAT- MEDLINE DCOM- 20201218 LR - 20210105 IS - 1873-6424 (Electronic) IS - 0269-7491 (Linking) VI - 268 IP - Pt A DP - 2021 Jan 1 TI - Prenatal exposure to perfluoroalkyl substances and cord plasma lipid concentrations. PG - 115426 LID - S0269-7491(20)36114-5 [pii] LID - 10.1016/j.envpol.2020.115426 [doi] AB - The effect of prenatal exposure to perfluoroalkyl substances (PFAS) on lipid concentrations in newborns is unknown. Using data from the Shanghai-Minhang Birth Cohort Study, we prospectively assessed the health effects of prenatal exposure to individual and multiple PFAS on cord lipid concentrations. Maternal plasma samples collected at 12-16 weeks of gestation were analyzed for eleven PFAS, and cord blood samples were analyzed for lipids: total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). We used multiple linear regression models to evaluate the associations of each individual PFAS with each lipid parameter, and used Bayesian Kernel Machine Regression (BKMR) models to assess the overall and single-exposure effects of eight PFAS with the detection rate above 80% on cord lipid concentrations. In multiple linear regression models, for each unit increase in ln-transformed maternal concentrations of perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUdA), and perfluorotridecanoic acid (PFTrDA), ln-transformed TC concentration decreased by 0.15 mg/dL (95% confidence interval (CI): -0.25, -0.05), 0.12 mg/dL (95% CI: -0.19, -0.05), 0.12 mg/dL (95% CI: -0.19, -0.05), and 0.05 mg/dL (95% CI: -0.09, -0.01), respectively, and ln-transformed HDL-C concentration decreased by 0.17 mg/dL (95% CI: -0.29, -0.05), 0.12 mg/dL (95% CI: -0.20, -0.03), 0.12 mg/dL (95% CI: -0.20, -0.03), and 0.06 mg/dL (95% CI: -0.11, -0.00), respectively. Statistically significant inverse associations were also observed between ln-transformed concentrations of PFDA, PFUdA, or PFTrDA and ln-transformed cord concentrations of TG and LDL-C. In BKMR models, the mixture of eight PFAS showed suggestively inverse association with all ln-transformed lipid concentrations, such that ln-transformed TC concentration of exposure to the 75th percentile of the mixture was 0.11 units (95% credible interval, -0.21, -0.01) lower than the 25th percentile exposure. Our findings indicated that prenatal exposure to PFAS may disrupt lipid metabolism in newborns. CI - Copyright (c) 2020 Elsevier Ltd. All rights reserved. FAU - Tian, Youping AU - Tian Y AD - National Management Office of Neonatal Screening Project for CHD, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China; NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, 779 Old Hu Min Road, Shanghai, 200237, China. FAU - Miao, Maohua AU - Miao M AD - NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, 779 Old Hu Min Road, Shanghai, 200237, China. FAU - Ji, Honglei AU - Ji H AD - NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, 779 Old Hu Min Road, Shanghai, 200237, China. FAU - Zhang, Xiaotian AU - Zhang X AD - National Reference Laboratory of Dioxin, Institute of Health Inspection and Detection, Hubei Provincial Academy of Preventive Medicine, Hubei Provincial Center for Disease Control and Prevention, #6 Zhuo Daoquan North Road, Wuhan, 430079, China. FAU - Chen, Aimin AU - Chen A AD - Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, 423 Guardian Drive, Philadelphia, 19104-6021, USA. FAU - Wang, Ziliang AU - Wang Z AD - NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, 779 Old Hu Min Road, Shanghai, 200237, China. FAU - Yuan, Wei AU - Yuan W AD - NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, 779 Old Hu Min Road, Shanghai, 200237, China. FAU - Liang, Hong AU - Liang H AD - NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, 779 Old Hu Min Road, Shanghai, 200237, China. Electronic address: lianghong@sippr.org.cn. LA - eng PT - Journal Article DEP - 20200821 PL - England TA - Environ Pollut JT - Environmental pollution (Barking, Essex : 1987) JID - 8804476 RN - 0 (Alkanesulfonic Acids) RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) RN - 0 (Lipids) SB - IM MH - *Alkanesulfonic Acids/toxicity MH - Bayes Theorem MH - China MH - Cohort Studies MH - *Environmental Pollutants MH - Female MH - *Fluorocarbons/toxicity MH - Humans MH - Infant, Newborn MH - Lipids MH - Maternal Exposure MH - Plasma MH - Pregnancy MH - *Prenatal Exposure Delayed Effects/chemically induced OTO - NOTNLM OT - Cord plasma OT - Lipids OT - Perfluoroalkyl substances OT - Prenatal exposure OT - Shanghai-Minhang Birth Cohort Study COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2020/11/06 06:00 MHDA- 2020/12/19 06:00 CRDT- 2020/11/05 20:17 PHST- 2020/04/29 00:00 [received] PHST- 2020/07/17 00:00 [revised] PHST- 2020/08/10 00:00 [accepted] PHST- 2020/11/06 06:00 [pubmed] PHST- 2020/12/19 06:00 [medline] PHST- 2020/11/05 20:17 [entrez] AID - S0269-7491(20)36114-5 [pii] AID - 10.1016/j.envpol.2020.115426 [doi] PST - ppublish SO - Environ Pollut. 2021 Jan 1;268(Pt A):115426. doi: 10.1016/j.envpol.2020.115426. Epub 2020 Aug 21.