PMID- 33152818
OWN - NLM
STAT- MEDLINE
DCOM- 20201109
LR  - 20201109
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 49
IP  - 11
DP  - 2020 Nov 8
TI  - [Cytogenetic abnormalities and morphological changes of bone marrow in multiple 
      myeloma: a pathological analysis of 151 cases].
PG  - 1136-1141
LID - 10.3760/cma.j.cn112151-20200306-00178 [doi]
AB  - Objective: To investigate the relationship between six common cytogenetic 
      abnormalities and bone marrow pathomorphology in multiple myeloma (MM). Methods: 
      Bone marrow biopsy was performed on 151 newly-diagnosed MM patients. Meanwhile, 
      myeloma cells were enriched by CD138 immunomagnetic beads, and then lq+, 13q-, 
      17p-, t(4;14), t (11;14), t (14;16) and other common genetic abnormalities were 
      detected using interphase fluorescence in situ hybridization (FISH). The 
      relationship between different genetic abnormalities and biopsy morphology was 
      compared. Results: Of the 151 patients, 15 had extramedullary infiltration 
      (9.9%). The rate of cytogenetic abnormalities was 76.2% (115/151), of which 1q+ 
      accounted for 49.7% (75/151), 13q-39.1% (59/151), 17p-8.6% (13/151), t(4;14) 
      21.2% (32/151), t(11;14) 19.2% (29/151), and t(14;16) 2.0% (3/151). The 
      proliferation patterns of MM plasma cells were nodular (48.3%, 73/151), 
      interstitial (33.8%, 51/151) and diffuse (17.9%, 27/151). The morphology of 
      plasma cells was mainly mature type (58.3%, 88/151), followed by juvenile type 
      (20.5%, 31/151), intermediate type (15.9%, 24/151) and plasmacyte type (5.3%, 
      8/151). According to the mSMART risk stratification system, the proliferation 
      pattern of myeloma cells in the high-risk group was mainly diffuse type, and the 
      morphology was mainly immature and plasmacyte type. In the middle-risk group, 
      mature type myeloma cells were mainly nodular proliferating. In the low-risk and 
      negative group, mature type myeloma cells were mainly interstitial proliferating. 
      There was no difference in the probability of different proliferation modes of 
      intermediate type plasma cells in each group. Conclusions: The proliferation 
      pattern and morphology of plasma cells in bone marrow biopsy combined with 
      cytogenetic markers can more accurately predict the severity and prognosis of MM.
FAU - Chen, H
AU  - Chen H
AD  - Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing 100043, China.
FAU - Zeng, B B
AU  - Zeng BB
AD  - Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing 100043, China.
FAU - Zhao, Y
AU  - Zhao Y
AD  - Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing 100043, China.
FAU - Xie, Y
AU  - Xie Y
AD  - Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing 100043, China.
FAU - Jin, M L
AU  - Jin ML
AD  - Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing 100043, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
SB  - IM
MH  - Adolescent
MH  - Bone Marrow
MH  - Chromosome Aberrations
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Multiple Myeloma/genetics
MH  - Plasma Cells
MH  - Prognosis
OTO - NOTNLM
OT  - Cytogenetics
OT  - Multiple myeloma
OT  - Pathology, clinical
EDAT- 2020/11/06 06:00
MHDA- 2020/11/11 06:00
CRDT- 2020/11/05 21:46
PHST- 2020/11/05 21:46 [entrez]
PHST- 2020/11/06 06:00 [pubmed]
PHST- 2020/11/11 06:00 [medline]
AID - 10.3760/cma.j.cn112151-20200306-00178 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2020 Nov 8;49(11):1136-1141. doi: 
      10.3760/cma.j.cn112151-20200306-00178.