PMID- 33153493
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20231112
IS  - 1478-6362 (Electronic)
IS  - 1478-6354 (Print)
IS  - 1478-6354 (Linking)
VI  - 22
IP  - 1
DP  - 2020 Nov 5
TI  - Pain sensitivity in young adults with juvenile idiopathic arthritis: a 
      quantitative sensory testing study.
PG  - 262
LID - 10.1186/s13075-020-02345-2 [doi]
LID - 262
AB  - BACKGROUND: To study for the first-time, pain perception, pain sensitivity, and 
      self-reported pain in young adults with long disease duration of juvenile 
      idiopathic arthritis (JIA) compared with controls. METHODS: Children from Central 
      Norway diagnosed with JIA between 1997 and 2004 were included consecutively in a 
      population-based prospective study. Children with onset 1997-2000 were part of 
      the Nordic JIA cohort. Controls were age- and sex-matched. In 2015-2017, study 
      visits with investigator-blinded quantitative sensory testing (QST) comprising 
      cold and warm detection thresholds (CDT/WDT), cold and heat pain thresholds 
      (CPT/HPT), pressure pain threshold (PPT), and a suprathreshold heat pain test 
      were performed. We constructed separate multilevel models for each variable of 
      detection and pain thresholds with interaction between groups and site adjusted 
      for the effect of age and sex. RESULTS: Among 96 young adults with JIA, 71% were 
      female, median age was 22.7 years, disease duration was 16.1 years, and 47% had 
      oligoarticular disease. Among 109 controls, 71% were female, and median age 
      was 23.5 years. Participants with JIA had lower pressure pain thresholds (PPTs) 
      (95% CI) compared to controls, upper limb 888 (846,930) versus 1029 (999,1059) 
      kPa and lower limb 702 (670,734) versus 760 (726,794) kPa. Participants with 
      inactive disease had the lowest PPTs and cold pain thresholds (CPTs), compared to 
      those in remission off medication and those with active disease. Minor 
      differences were found regarding CDT/WDT and CPT/HPT in JIA compared to controls. 
      The median (IQR) temperature needed to evoke pain = 6 on a 0-10 numeric rating 
      scale (NRS) in the suprathreshold heat pain tests were lower in JIA than in 
      controls (46  degrees C (45-47  degrees C) versus 47  degrees C (46-48  degrees C)). We found no associations 
      between self-reported pain and pain thresholds. CONCLUSIONS: Our results indicate 
      for the first time that young adults with long disease duration of JIA may have 
      altered pain perception and sensitivity compared to controls. A clinical 
      implication may be the importance of early treatment to quickly achieve pain-free 
      remission and avoid long-term pain sensitization.
FAU - Arnstad, Ellen Dalen
AU  - Arnstad ED
AUID- ORCID: 0000-0003-0635-5198
AD  - Department of Pediatrics, Levanger Hospital, Nord-Trondelag Hospital Trust, 
      Levanger, Norway. ellen.d.arnstad@ntnu.no.
AD  - Department of Clinical and Molecular Medicine, NTNU-Norwegian University of 
      Science and Technology, Trondheim, Norway. ellen.d.arnstad@ntnu.no.
FAU - Iversen, Johanne Marie
AU  - Iversen JM
AD  - Department of Internal Medicine, Nordland Hospital, Bodo, Norway.
FAU - Uglem, Martin
AU  - Uglem M
AD  - Department of Neuromedicine and Movement Science, NTNU-Norwegian University of 
      Science and Technology, Trondheim, Norway.
AD  - Department of Neurology and Clinical Neurophysiology, St. Olavs Hospital, 
      Trondheim, Norway.
FAU - Glerup, Mia
AU  - Glerup M
AD  - Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark.
FAU - Romundstad, Pal Richard
AU  - Romundstad PR
AD  - Department of Public Health and Nursing, NTNU-Norwegian University of Science and 
      Technology, Trondheim, Norway.
FAU - Sand, Trond
AU  - Sand T
AD  - Department of Neuromedicine and Movement Science, NTNU-Norwegian University of 
      Science and Technology, Trondheim, Norway.
AD  - Department of Neurology and Clinical Neurophysiology, St. Olavs Hospital, 
      Trondheim, Norway.
FAU - Rygg, Marite
AU  - Rygg M
AD  - Department of Clinical and Molecular Medicine, NTNU-Norwegian University of 
      Science and Technology, Trondheim, Norway.
AD  - Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201105
PL  - England
TA  - Arthritis Res Ther
JT  - Arthritis research & therapy
JID - 101154438
SB  - IM
MH  - Adult
MH  - *Arthritis, Juvenile/complications/diagnosis
MH  - Child
MH  - Female
MH  - Humans
MH  - Male
MH  - Norway/epidemiology
MH  - Pain
MH  - *Pain Threshold
MH  - Prospective Studies
MH  - Young Adult
PMC - PMC7643261
OTO - NOTNLM
OT  - Juvenile idiopathic arthritis (JIA)
OT  - Long-term outcomes
OT  - Pain perception
OT  - Pain sensitivity
OT  - Pain sensitization
OT  - Pain threshold
OT  - Quantitative sensory testing (QST)
OT  - Self-reported pain
OT  - Young adults
COIS- The authors declare that they have no competing interests.
EDAT- 2020/11/07 06:00
MHDA- 2021/06/22 06:00
PMCR- 2020/11/05
CRDT- 2020/11/06 05:36
PHST- 2020/09/14 00:00 [received]
PHST- 2020/10/05 00:00 [accepted]
PHST- 2020/11/06 05:36 [entrez]
PHST- 2020/11/07 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/11/05 00:00 [pmc-release]
AID - 10.1186/s13075-020-02345-2 [pii]
AID - 2345 [pii]
AID - 10.1186/s13075-020-02345-2 [doi]
PST - epublish
SO  - Arthritis Res Ther. 2020 Nov 5;22(1):262. doi: 10.1186/s13075-020-02345-2.