PMID- 33154692
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220418
IS  - 1179-2744 (Print)
IS  - 1179-2744 (Electronic)
IS  - 1179-2744 (Linking)
VI  - 12
DP  - 2020
TI  - A Review of Neuro-Ophthalmological Manifestations of Human Coronavirus Infection.
PG  - 129-137
LID - 10.2147/EB.S268828 [doi]
AB  - INTRODUCTION: Human coronavirus (HCoVs) are a group of viruses with recognized 
      neurotropic and neuroinvasive capabilities. The reports on the neurological and 
      ocular findings are increasing day after day and several central and peripheral 
      neurological manifestations are already described. However, none specifically 
      describes the neuro-ophthalmological manifestation of HCoVs. This is the first 
      article specifically reviewing neuro-ophthalmological manifestations of HCoVs 
      infection. METHODS: PubMed and Google Scholar databases were searched using the 
      keywords: coronaviridae, coronavirus, COVID-19, SARS-CoV-2, SARS-CoV-1, MERS, 
      ocular, ophthalmology, ophthalmological, neuro-ophthalmology, neurological, 
      manifestations. A manual search through the reference lists of relevant articles 
      was also performed. There were no restrictions concerning language or study type 
      and publications not yet printed but available online were considered. RESULTS: 
      Coronavirus eye involvement is not frequent and includes mostly a typical viral 
      follicular conjunctivitis. Recently, retinal anatomical alterations were 
      described using optic coherence tomography. Neuro-ophthalmological symptoms and 
      signs can appear isolated or associated with neurological syndromes. The 
      manifestations include headache, ocular pain, visual impairment, diplopia, and 
      cranial nerve palsies secondary to Miller Fisher syndrome, Guillain-Barre 
      syndrome, or encephalitis, and nystagmus. CONCLUSION: Neurological and 
      neuro-ophthalmological syndromes, symptoms, and signs should not be neglected and 
      a complete ophthalmological examination of these patients should be performed to 
      fully describe ocular manifestations related to HCoVs. We believe that major 
      ocular and neuro-ophthalmological manifestations reports lack due to safety 
      issues concerning detailed ophthalmological examination; on the other hand, in a 
      large number of cases, the presence of life-threatening coronavirus disease 
      hinders ocular examination and ophthalmologist's visit to the intensive care 
      unit.
CI  - (c) 2020 Luis et al.
FAU - Luis, Maria Elisa
AU  - Luis ME
AUID- ORCID: 0000-0002-9361-089X
AD  - Ophthalmology Department, Centro Hospitalar Universitario de Lisboa Central, 
      Lisbon, Portugal.
FAU - Hipolito-Fernandes, Diogo
AU  - Hipolito-Fernandes D
AD  - Ophthalmology Department, Centro Hospitalar Universitario de Lisboa Central, 
      Lisbon, Portugal.
FAU - Mota, Catarina
AU  - Mota C
AD  - Ophthalmology Department, Centro Hospitalar Universitario de Lisboa Central, 
      Lisbon, Portugal.
FAU - Maleita, Diogo
AU  - Maleita D
AD  - Ophthalmology Department, Centro Hospitalar Universitario de Lisboa Central, 
      Lisbon, Portugal.
FAU - Xavier, Catarina
AU  - Xavier C
AD  - Ophthalmology Department, Centro Hospitalar Universitario de Lisboa Central, 
      Lisbon, Portugal.
FAU - Maio, Tiago
AU  - Maio T
AD  - Ophthalmology Department, Hospital Pedro Hispano, Matosinhos, Portugal.
FAU - Cunha, Joao Paulo
AU  - Cunha JP
AD  - Ophthalmology Department, Hospital CUF Cascais, Lisbon, Portugal.
AD  - Escola Superior de Tecnologia da Saude de Lisboa do Instituto Politecnico de 
      Lisboa, Lisbon, Portugal.
FAU - Tavares Ferreira, Joana
AU  - Tavares Ferreira J
AUID- ORCID: 0000-0002-2237-3962
AD  - Ophthalmology Department, Hospital CUF Cascais, Lisbon, Portugal.
AD  - Escola Superior de Tecnologia da Saude de Lisboa do Instituto Politecnico de 
      Lisboa, Lisbon, Portugal.
AD  - Neuro-Ophthalmology Department, Centro Hospitalar Universitario de Lisboa Norte, 
      Lisbon, Portugal.
AD  - Centro de Estudos das Ciencias da Visao, Faculdade de Medicina da Universidade de 
      Lisboa, Lisbon, Portugal.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201030
PL  - New Zealand
TA  - Eye Brain
JT  - Eye and brain
JID - 101587774
PMC - PMC7608548
OTO - NOTNLM
OT  - human coronavirus
OT  - manifestations
OT  - neuro-ophthalmological
OT  - neurotropic
OT  - ophthalmology
COIS- There are no financial conflicts of interest to disclose. The authors report no 
      conflicts of interest for this work.
EDAT- 2020/11/07 06:00
MHDA- 2020/11/07 06:01
PMCR- 2020/10/30
CRDT- 2020/11/06 05:59
PHST- 2020/06/22 00:00 [received]
PHST- 2020/09/05 00:00 [accepted]
PHST- 2020/11/06 05:59 [entrez]
PHST- 2020/11/07 06:00 [pubmed]
PHST- 2020/11/07 06:01 [medline]
PHST- 2020/10/30 00:00 [pmc-release]
AID - 268828 [pii]
AID - 10.2147/EB.S268828 [doi]
PST - epublish
SO  - Eye Brain. 2020 Oct 30;12:129-137. doi: 10.2147/EB.S268828. eCollection 2020.