PMID- 33155514
OWN - NLM
STAT- MEDLINE
DCOM- 20230321
LR  - 20230321
IS  - 1744-4160 (Electronic)
IS  - 1381-3455 (Linking)
VI  - 129
IP  - 2
DP  - 2023 Apr
TI  - Non-coding RNAs and type 2 diabetes mellitus.
PG  - 526-535
LID - 10.1080/13813455.2020.1843498 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a worldwide disease with rapidly increasing 
      prevalence. This complex disorder caused by interplay between genetic 
      predisposition factors, early developmental elements, diet and inactive 
      lifestyle. Several researches have shown impact of long non-coding RNAs (lncRNAs) 
      and microRNAs (miRNAs) in the pathogenesis of this disorder. Several miRNAs such 
      as miR-126, miR-222-3p, miR-182, let-7b-5p, and miR-1-3p have been down-regulated 
      in different biological sources of patients with T2DM. Some other miRNAs 
      including miR-21, miR-30d, miR-148a-3p, miR-146b and miR-486 have the opposite 
      trends. In addition, a number of lncRNAs such as LY86-AS, HCG27_201, VIM-AS1, 
      CTBP1-AS2, CASC2, GAS5, LINC-PINT, and MALAT1 have been altered in the peripheral 
      blood, serum samples or tissues obtained from patients with T2DM. Taken together, 
      both miRNAs and lncRNAs contribute to the development of T2DM and might be 
      applied as markers or therapeutic molecules for this disorder.
FAU - Taheri, Mohammad
AU  - Taheri M
AD  - Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
FAU - Eghtedarian, Reyhane
AU  - Eghtedarian R
AD  - Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
FAU - Ghafouri-Fard, Soudeh
AU  - Ghafouri-Fard S
AD  - Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
FAU - Omrani, Mir Davood
AU  - Omrani MD
AD  - Urology and Nephrology Research Center, Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20201106
PL  - England
TA  - Arch Physiol Biochem
JT  - Archives of physiology and biochemistry
JID - 9510153
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2
MH  - *RNA, Long Noncoding/genetics
MH  - *MicroRNAs/genetics
OTO - NOTNLM
OT  - lncRNA
OT  - miRNA
OT  - type 2 diabetes mellitus
EDAT- 2020/11/07 06:00
MHDA- 2023/03/22 06:00
CRDT- 2020/11/06 08:39
PHST- 2020/11/07 06:00 [pubmed]
PHST- 2023/03/22 06:00 [medline]
PHST- 2020/11/06 08:39 [entrez]
AID - 10.1080/13813455.2020.1843498 [doi]
PST - ppublish
SO  - Arch Physiol Biochem. 2023 Apr;129(2):526-535. doi: 
      10.1080/13813455.2020.1843498. Epub 2020 Nov 6.