PMID- 33155569
OWN - NLM
STAT- MEDLINE
DCOM- 20210412
LR  - 20210412
IS  - 2589-1294 (Electronic)
IS  - 1017-995X (Print)
IS  - 1017-995X (Linking)
VI  - 54
IP  - 5
DP  - 2020 Sep
TI  - Rapid progression of scoliosis curve in a mature patient with undiagnosed 
      pituitary macroadenoma: A rare case report.
PG  - 561-564
LID - 10.5152/j.aott.2020.19144 [doi]
AB  - Growth hormone secreting pituitary tumor or gigantism has not been previously 
      reported to be associated with rapid progression of scoliosis in the literature. 
      However, there are some reports indicating scoliosis can be worsened by growth 
      hormone therapy in children and adolescents. A 19-year-old boy was referred to 
      our institution for the treatment of a right thoracolumbar scoliosis. The Cobb 
      angle had worsened from 29 degrees  to 83 degrees  over two years' duration. He attained puberty 
      at the age of 13. He had a previous history of slipped upper femoral epiphysis 
      (SUFE), which was operated in 2015, with no clinical features of gigantism. 
      Preoperative assessment was performed. He was diagnosed with growth hormone 
      secreting pituitary macroadenoma by magnetic resonance imaging with a high serum 
      level of insulin-like growth factor-I (IGF-I). Computed tomography (CT) of the 
      pancreas showed a pancreatic endocrine tumor. The patient was later diagnosed 
      with multiple endocrine neoplasia type 1 (MEN 1). He underwent endoscopic 
      endonasal excision of the pituitary mass and distal pancreatectomy. This case 
      indicates that growth hormone secreting pituitary macroadenoma could result in 
      rapid progression of scoliosis.
FAU - Chung, Weng Hong
AU  - Chung WH
AD  - Department of Orthopaedic Surgery (NOCERAL), University of Malaya, School of 
      Medicine, Kuala Lumpur, Malaysia.
FAU - Chiu, Chee Kidd
AU  - Chiu CK
AD  - Department of Orthopaedic Surgery (NOCERAL), University of Malaya, School of 
      Medicine, Kuala Lumpur, Malaysia.
FAU - Wei Chan, Chris Yin
AU  - Wei Chan CY
AD  - Department of Orthopaedic Surgery (NOCERAL), University of Malaya, School of 
      Medicine, Kuala Lumpur, Malaysia.
FAU - Kwan, Mun Keong
AU  - Kwan MK
AD  - Department of Orthopaedic Surgery (NOCERAL), University of Malaya, School of 
      Medicine, Kuala Lumpur, Malaysia.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Turkey
TA  - Acta Orthop Traumatol Turc
JT  - Acta orthopaedica et traumatologica turcica
JID - 9424806
RN  - 0 (IGF1 protein, human)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - Combined Pituitary Hormone Deficiency
SB  - IM
MH  - *Adenoma/blood/pathology/physiopathology/surgery
MH  - Humans
MH  - Hypophysectomy/*methods
MH  - *Hypopituitarism/diagnosis/etiology/therapy
MH  - Insulin-Like Growth Factor I/analysis
MH  - *Insulinoma/pathology/surgery
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Multiple Endocrine Neoplasia Type 1/*diagnosis
MH  - Pancreatectomy/methods
MH  - *Pancreatic Neoplasms/pathology/surgery
MH  - Patient Care Management/methods
MH  - Pituitary Gland/diagnostic imaging/surgery
MH  - *Pituitary Neoplasms/blood/pathology/physiopathology/surgery
MH  - Radiography/methods
MH  - *Scoliosis/diagnostic imaging/etiology
MH  - Tomography, X-Ray Computed/*methods
MH  - Young Adult
PMC - PMC7646617
COIS- Conflict of Interest: The authors have no conflicts of interest to declare.
EDAT- 2020/11/07 06:00
MHDA- 2021/04/13 06:00
PMCR- 2020/09/01
CRDT- 2020/11/06 08:40
PHST- 2020/11/06 08:40 [entrez]
PHST- 2020/11/07 06:00 [pubmed]
PHST- 2021/04/13 06:00 [medline]
PHST- 2020/09/01 00:00 [pmc-release]
AID - aott-54-5-561 [pii]
AID - 10.5152/j.aott.2020.19144 [doi]
PST - ppublish
SO  - Acta Orthop Traumatol Turc. 2020 Sep;54(5):561-564. doi: 
      10.5152/j.aott.2020.19144.