PMID- 33155893
OWN - NLM
STAT- MEDLINE
DCOM- 20220107
LR  - 20220107
IS  - 1875-5402 (Electronic)
IS  - 1386-2073 (Linking)
VI  - 24
IP  - 9
DP  - 2021
TI  - Serum Pro-oxidant-antioxidant Balance in Subjects with Type 2 Diabetes Mellitus.
PG  - 1476-1481
LID - 10.2174/1386207323999201103203153 [doi]
AB  - AIM AND OBJECTIVE: Diabetes mellitus is associated with inflammation and 
      increased oxidative stress. In the current study, we aimed to investigate the 
      relationship between type 2 diabetes mellitus (T2DM) and serum 
      pro-oxidant-antioxidant balance (PAB) in a large populationbased study. METHODS: 
      In this cross-sectional study, 7888 individuals were recruited as part of the 
      Mashhad Stroke and Heart Atherosclerotic Disorders (MASHAD) cohort study. 
      Participants were divided into three groups based on their serum PAB values 
      (levels < 36.4, 36.4-82.6 and > 82.6 HK). Serum PAB values were measured using a 
      colorimetric method and enzyme-linked immune sorbent assay (ELISA). RESULTS: 
      Serum PAB in subjects with and without diabetes was reported 76.85 +/- 61.07 HK and 
      69.51 +/- 55.50 HK. In subjects with a serum PAB > 82.6 HK the risk of T2DM was 1.2 
      fold higher in comparison to subjects with a serum PAB < 36.4 HK (OR: 1.26, 95% 
      CI: 1.09 - 1.47, P-value: 0.002). This association remained significant after 
      adjustment for confounding factors in multivariable analysis (OR: 1.19, 95% CI: 
      1.02 - 1.38, P-value: 0.027). CONCLUSION: Increased pro-oxidant levels may be a 
      major complication of T2DM in our study subjects and PAB could be an indicator of 
      higher oxidative stress in T2DM patients from northeastern Iran.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Ahmadnezhad, Mahsa
AU  - Ahmadnezhad M
AD  - Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
FAU - Ghazizadeh, Hamideh
AU  - Ghazizadeh H
AD  - Student Research Committee, Mashhad University of Medical Sciences, Mashhad, 
      Iran.
FAU - Bijari, Moniba
AU  - Bijari M
AD  - Metabolic syndrome Research center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
FAU - Oladi, Mohammad Reza
AU  - Oladi MR
AD  - International UNESCO Center for Health- Related Basic Sciences and Human 
      Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Esmaily, Habibollah
AU  - Esmaily H
AD  - Social Determinants of Health Research Center, Mashhad University of Medical 
      sciences, Mashhad, Iran.
FAU - Hoseini, Seyed Javad
AU  - Hoseini SJ
AD  - Metabolic syndrome Research center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
FAU - Barati, Elham
AU  - Barati E
AD  - Metabolic syndrome Research center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
FAU - Silakhori, Samaneh
AU  - Silakhori S
AD  - Metabolic syndrome Research center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
FAU - Mohammadi-Bajgiran, Maryam
AU  - Mohammadi-Bajgiran M
AD  - Metabolic syndrome Research center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
FAU - Davari, Hafezeh
AU  - Davari H
AD  - Metabolic syndrome Research center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
FAU - Parizadeh, Mohammad Reza
AU  - Parizadeh MR
AD  - Metabolic syndrome Research center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
FAU - Mokhber, Naghme
AU  - Mokhber N
AD  - Department of Psychiatry, Faculty of Medicine &amp; Psychiatric Research Centre, 
      Ebn-sina Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Sharifan, Payam
AU  - Sharifan P
AD  - Student Research Committee, Mashhad University of Medical Sciences, Mashhad, 
      Iran.
FAU - Aref-Hosseini, Seyed Rafie
AU  - Aref-Hosseini SR
AD  - Department of Nutrition Biochemistry, Tabriz University of Medical Sciences, 
      Tabriz, Iran.
FAU - Ferns, Gordon A
AU  - Ferns GA
AD  - Brighton &amp; Sussex Medical School, Division of Medical Education, Falmer, 
      Brighton, Sussex BN1 9PH, United Kingdom.
FAU - Moohebati, Mohsen
AU  - Moohebati M
AD  - Cardiovascular Research Center, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Ghayour-Mobarhan, Majid
AU  - Ghayour-Mobarhan M
AD  - Metabolic syndrome Research center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
LA  - eng
GR  - 85134/Mashhad University of Medical Science (MUMS)/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United Arab Emirates
TA  - Comb Chem High Throughput Screen
JT  - Combinatorial chemistry & high throughput screening
JID - 9810948
RN  - 0 (Antioxidants)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antioxidants/*analysis
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Humans
MH  - Middle Aged
MH  - Reactive Oxygen Species/*blood
OTO - NOTNLM
OT  - MASHAD cohort study
OT  - Pro-oxidant-Antioxidant balance
OT  - Type 2 diabetes mellitus
OT  - inflammation.
OT  - oxidative stress
EDAT- 2020/11/07 06:00
MHDA- 2022/01/08 06:00
CRDT- 2020/11/06 12:11
PHST- 2020/06/23 00:00 [received]
PHST- 2020/10/13 00:00 [revised]
PHST- 2020/10/23 00:00 [accepted]
PHST- 2020/11/07 06:00 [pubmed]
PHST- 2022/01/08 06:00 [medline]
PHST- 2020/11/06 12:11 [entrez]
AID - CCHTS-EPUB-111170 [pii]
AID - 10.2174/1386207323999201103203153 [doi]
PST - ppublish
SO  - Comb Chem High Throughput Screen. 2021;24(9):1476-1481. doi: 
      10.2174/1386207323999201103203153.