PMID- 33156155
OWN - NLM
STAT- MEDLINE
DCOM- 20211015
LR  - 20211102
IS  - 1465-7309 (Electronic)
IS  - 1067-3229 (Print)
IS  - 1067-3229 (Linking)
VI  - 28
IP  - 6
DP  - 2020 Nov/Dec
TI  - Negative Symptoms and Functioning in Youth at Risk of Psychosis: A Systematic 
      Review and Meta-analysis.
PG  - 341-355
LID - 10.1097/HRP.0000000000000273 [doi]
AB  - LEARNING OBJECTIVE: After participating in this activity, learners should be 
      better able to:* Evaluate the relationship between negative symptoms and 
      functioning in youth at clinical high risk for psychosis. AIM: Youth at CHR for 
      psychosis often demonstrate significant negative symptoms and poor functioning, 
      though the magnitude and direction of the relationship between the two remains 
      unknown. The objective of this systematic review is to summarize the relationship 
      between negative symptoms and functioning in CHR samples. METHOD: Electronic 
      databases CINAHL, EBM, Embase, MEDLINE, and PsycINFO were searched from 
      inception. Studies were selected if they included any study that reported a 
      relationship between negative symptoms and functioning in youth at clinical high 
      risk (CHR). The correlation coefficient r was converted to Cohen's d, and all 
      random-effects meta-analyses were performed using the transformed values. 
      RESULTS: Forty-one studies met the inclusion criteria, including a total of 4574 
      individuals at CHR for psychosis. Negative symptom total scores were 
      significantly associated with poorer global functioning (d, -1.40; 95% CI, -1.82 
      to -0.98; I = 79.4%; p < .001 [9 studies, n = 782]), social functioning (d, 
      -1.10; 95% CI, -1.27 to -0.93; I = 10.40%; p < .001 [12 studies, n = 811]), and 
      role functioning (d, -0.96; 95% CI, -1.17 to -0.76; I = 41.1%; p < .001 [9 
      studies, n = 881]). In addition, negative symptoms were consistently associated 
      with poor premorbid functioning. When examining negative symptom domains, 
      avolition, anhedonia, and blunted affect were each significantly and 
      independently associated with poorer social functioning and role functioning. In 
      terms of prediction models, negative symptoms contributed to the prediction of 
      lower functioning across multiple studies. CONCLUSION: This meta-analysis 
      demonstrates a strong relationship between negative symptoms and functioning in 
      youth at clinical high risk for psychosis.
FAU - Devoe, Daniel J
AU  - Devoe DJ
AD  - From the Department of Psychiatry, Hotchkiss Brain Institute, University of 
      Calgary.
FAU - Braun, Amy
AU  - Braun A
FAU - Seredynski, Thomas
AU  - Seredynski T
FAU - Addington, Jean
AU  - Addington J
LA  - eng
GR  - R01 MH105178/MH/NIMH NIH HHS/United States
GR  - U01 MH081984/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
PL  - United States
TA  - Harv Rev Psychiatry
JT  - Harvard review of psychiatry
JID - 9312789
SB  - IM
MH  - Humans
MH  - Psychotic Disorders/diagnosis/*psychology
MH  - Risk Assessment
MH  - *Social Adjustment
MH  - Social Behavior Disorders/diagnosis/*psychology
MH  - Young Adult
PMC - PMC8527275
MID - NIHMS1626032
COIS- Disclosure Statement The authors declare no conflict of interest.
EDAT- 2020/11/07 06:00
MHDA- 2021/10/16 06:00
PMCR- 2021/11/01
CRDT- 2020/11/06 12:12
PHST- 2020/11/06 12:12 [entrez]
PHST- 2020/11/07 06:00 [pubmed]
PHST- 2021/10/16 06:00 [medline]
PHST- 2021/11/01 00:00 [pmc-release]
AID - 00023727-202011000-00001 [pii]
AID - 10.1097/HRP.0000000000000273 [doi]
PST - ppublish
SO  - Harv Rev Psychiatry. 2020 Nov/Dec;28(6):341-355. doi: 
      10.1097/HRP.0000000000000273.