PMID- 33156444
OWN - NLM
STAT- MEDLINE
DCOM- 20211004
LR  - 20211004
IS  - 1863-4362 (Electronic)
IS  - 0021-1265 (Linking)
VI  - 190
IP  - 3
DP  - 2021 Aug
TI  - Reduced JKAP correlates with advanced disease features, inflammation, as well as 
      increased exacerbation risk and severity in asthmatic children.
PG  - 1079-1085
LID - 10.1007/s11845-020-02422-0 [doi]
AB  - BACKGROUND: This study aimed to investigate the correlation of JNK 
      pathway-associated phosphatase (JKAP) with clinical features, inflammation, 
      exacerbation risk, and severity in asthmatic children. METHODS: Asthmatic 
      exacerbation children (N = 90), asthmatic remission children (N = 90), and 
      healthy controls (N = 90) were enrolled in this case-control study, whose venous 
      blood samples were collected after enrollment for routine blood test, JKAP, and 
      inflammatory cytokines detection by enzyme-linked immune sorbent assay. The 
      clinical features included demographic data, family history of asthma, and 
      pulmonary ventilation function. RESULTS: JKAP level was the lowest in asthmatic 
      exacerbation children, followed by asthmatic remission children and healthy 
      controls. ROC curve revealed good ability of JKAP in distinguishing three groups 
      from each other, especially in telling asthmatic exacerbation children from 
      healthy controls (AUC: 0.926; 95%CI: 0.887-0.965). In addition, JKAP was 
      negatively correlated with eosinophil count, immunoglobulin E (IgE), tumor 
      necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), 
      and interleukin-17 (IL-17), positively correlated with forced expiratory volume 
      in 1 sec/forced vital capacity (FEV(1)/FVC) and FEV(1) (%predicted) in asthmatic 
      exacerbation children. Whereas in asthmatic remission children, JKAP was 
      negatively correlated with eosinophil count, TNF-alpha, IL-1beta, IL-6, and IL-17 and 
      positively correlated with FEV(1) (%predicted), but not with IgE or FEV(1)/FVC. 
      In healthy controls, the correlation of JKAP with clinical features and 
      inflammatory cytokines was non-obvious. For exacerbation severity, JKAP was the 
      highest in mild exacerbation children, followed by moderate exacerbation 
      children, and severe exacerbation children. CONCLUSION: JKAP serves as a 
      potential biomarker for asthmatic susceptibility, inflammation, exacerbation 
      risk, and severity in children.
CI  - (c) 2020. Royal Academy of Medicine in Ireland.
FAU - Han, Hong
AU  - Han H
AD  - Department of Pediatrics, Xingtai People's Hospital, 16 Hongxing Street, Xiangdu 
      District, Xingtai, 054001, China.
FAU - Lu, Jianli
AU  - Lu J
AD  - Department of Pediatrics, Xingtai People's Hospital, 16 Hongxing Street, Xiangdu 
      District, Xingtai, 054001, China.
FAU - Chen, Cuirong
AU  - Chen C
AD  - Department of Anesthesiology, Xingtai People's Hospital, Xingtai, 054001, China.
FAU - Wang, Yi
AU  - Wang Y
AD  - Department of Pediatrics, Xingtai People's Hospital, 16 Hongxing Street, Xiangdu 
      District, Xingtai, 054001, China.
FAU - Han, Yanjun
AU  - Han Y
AUID- ORCID: 0000-0002-9025-237X
AD  - Department of Pediatrics, Xingtai People's Hospital, 16 Hongxing Street, Xiangdu 
      District, Xingtai, 054001, China. jugengbei546296@163.com.
LA  - eng
GR  - No.20191713/Project of Hebei Health Commission/
PT  - Journal Article
DEP - 20201106
PL  - Ireland
TA  - Ir J Med Sci
JT  - Irish journal of medical science
JID - 7806864
RN  - EC 3.1.3.2 (Phosphoric Monoester Hydrolases)
SB  - IM
MH  - *Asthma
MH  - Case-Control Studies
MH  - Child
MH  - Humans
MH  - Inflammation
MH  - *MAP Kinase Signaling System
MH  - Phosphoric Monoester Hydrolases
OTO - NOTNLM
OT  - Asthmatic children
OT  - Clinical features
OT  - Exacerbation
OT  - Inflammation
OT  - JKAP
EDAT- 2020/11/07 06:00
MHDA- 2021/10/05 06:00
CRDT- 2020/11/06 12:14
PHST- 2020/09/10 00:00 [received]
PHST- 2020/10/21 00:00 [accepted]
PHST- 2020/11/07 06:00 [pubmed]
PHST- 2021/10/05 06:00 [medline]
PHST- 2020/11/06 12:14 [entrez]
AID - 10.1007/s11845-020-02422-0 [pii]
AID - 10.1007/s11845-020-02422-0 [doi]
PST - ppublish
SO  - Ir J Med Sci. 2021 Aug;190(3):1079-1085. doi: 10.1007/s11845-020-02422-0. Epub 
      2020 Nov 6.