PMID- 33156844
OWN - NLM
STAT- MEDLINE
DCOM- 20201223
LR  - 20201223
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 15
IP  - 11
DP  - 2020
TI  - Investigation of micellar and interfacial phenomenon of amitriptyline 
      hydrochloride with cationic ester-bonded gemini surfactant mixture in different 
      solvent media.
PG  - e0241300
LID - 10.1371/journal.pone.0241300 [doi]
LID - e0241300
AB  - Herein, the interaction among the antidepressant drug amitriptyline hydrochloride 
      (AMT) and a green gemini surfactant, ethane-1, 2-diyl 
      bis(N,N-dimethyl-N-tetradecylammoniumacetoxy) dichloride (14-E2-14), via numerous 
      techniques such as tensiometry, fluorimetry, FT-IR and UV-visible spectroscopy in 
      three different media (aqueous 0.050 mol.kg-1 NaCl, 0.50 and 1.0 mol.kg-1 urea) 
      were investigated. AMT is used to treat mental illness or mood problems, such as 
      depression. The aggregation of biologically active ingredients can enhance the 
      bioavailability of hydrophobic drugs. A significant interaction between AMT and 
      14-E2-14 was detected by tensiometric study as the critical micelle concentration 
      (cmc) of AMT+14-E2-14 is reduced upon an increase of mole fraction (alpha1) of 
      14-E2-14. The decrease in cmc indicates the nonideality of studied mixtures of 
      different compositions. Although, employed drug AMT is freely soluble in the 
      aqueous and non-aqueous system but is not hydrophobic enough to act as its 
      carrier. Instead, gemini surfactant formed spherical micelles in an aqueous 
      system and their high solubilization capability, as well as their relatively 
      lower cmc value, makes them highly stable in vivo. The cmc values of AMT+14-E-14 
      mixtures in all cases were further decreased and increased in NaCl and urea 
      solutions respectively as compared with the aqueous system. Numerous micellar, 
      interfacial, and thermodynamic parameters have been measured by applying various 
      theoretical models. The obtained changes in the physicochemical assets of AMT 
      upon adding of 14-E2-14 are likely to enhance the industrial and pharmaceutical 
      applications of gemini surfactants. The negative interaction parameters (betam and 
      betasigma), indicate synergistic attraction is occurring in the mixed systems. The 
      aggregation number (Nagg), Stern-Volmer constant (Ksv), etc. are attained through 
      the fluorescence method, also supporting the attractive interaction behavior of 
      AMT+14-E2-14 mixtures in all solvents. The Nagg was found to increase in the salt 
      solution and decrease in the urea system compared with the aqueous solution. 
      FT-IR and UV-visible analysis also depict the interaction between the constituent 
      alike tensiometry and fluorimetry methods. The results suggested that gemini 
      surfactants may serve as a capable drug delivery agent for antidepressants, 
      improving their bioavailability.
FAU - Abdul Rub, Malik
AU  - Abdul Rub M
AUID- ORCID: 0000-0002-4798-5308
AD  - Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, 
      Saudi Arabia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201106
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Cations)
RN  - 0 (Esters)
RN  - 0 (Micelles)
RN  - 0 (Solutions)
RN  - 0 (Solvents)
RN  - 0 (Surface-Active Agents)
RN  - 1806D8D52K (Amitriptyline)
SB  - IM
MH  - Amitriptyline/*chemistry
MH  - Cations
MH  - Esters/*chemistry
MH  - *Micelles
MH  - Molecular Conformation
MH  - Solutions
MH  - Solvents/*chemistry
MH  - Spectrometry, Fluorescence
MH  - Spectrophotometry, Ultraviolet
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Surface Tension
MH  - Surface-Active Agents/chemical synthesis/*chemistry
MH  - Thermodynamics
PMC - PMC7647059
COIS- The authors have declared that no competing interests exist.
EDAT- 2020/11/07 06:00
MHDA- 2020/12/29 06:00
PMCR- 2020/11/06
CRDT- 2020/11/06 17:35
PHST- 2020/08/19 00:00 [received]
PHST- 2020/10/12 00:00 [accepted]
PHST- 2020/11/06 17:35 [entrez]
PHST- 2020/11/07 06:00 [pubmed]
PHST- 2020/12/29 06:00 [medline]
PHST- 2020/11/06 00:00 [pmc-release]
AID - PONE-D-20-24800 [pii]
AID - 10.1371/journal.pone.0241300 [doi]
PST - epublish
SO  - PLoS One. 2020 Nov 6;15(11):e0241300. doi: 10.1371/journal.pone.0241300. 
      eCollection 2020.