PMID- 33156853
OWN - NLM
STAT- MEDLINE
DCOM- 20210129
LR  - 20210129
IS  - 1553-7358 (Electronic)
IS  - 1553-734X (Print)
IS  - 1553-734X (Linking)
VI  - 16
IP  - 11
DP  - 2020 Nov
TI  - Interspike intervals within retinal spike bursts combinatorially encode multiple 
      stimulus features.
PG  - e1007726
LID - 10.1371/journal.pcbi.1007726 [doi]
LID - e1007726
AB  - Neurons in various regions of the brain generate spike bursts. While the number 
      of spikes within a burst has been shown to carry information, information coding 
      by interspike intervals (ISIs) is less well understood. In particular, a burst 
      with k spikes has k-1 intraburst ISIs, and these k-1 ISIs could theoretically 
      encode k-1 independent values. In this study, we demonstrate that such 
      combinatorial coding occurs for retinal bursts. By recording ganglion cell spikes 
      from isolated salamander retinae, we found that intraburst ISIs encode 
      oscillatory light sequences that are much faster than the light intensity 
      modulation encoded by the number of spikes. When a burst has three spikes, the 
      two intraburst ISIs combinatorially encode the amplitude and phase of the 
      oscillatory sequence. Analysis of trial-to-trial variability suggested that 
      intraburst ISIs are regulated by two independent mechanisms responding to 
      orthogonal oscillatory components, one of which is common to bursts with a 
      different number of spikes. Therefore, the retina encodes multiple stimulus 
      features by exploiting all degrees of freedom of burst spike patterns, i.e., the 
      spike number and multiple intraburst ISIs.
FAU - Ishii, Toshiyuki
AU  - Ishii T
AUID- ORCID: 0000-0002-5067-1035
AD  - RIKEN Center for Brain Science and RIKEN Brain Science Institute, Wako-shi, 
      Saitama, Japan.
AD  - Toho University, Funabashi-shi, Chiba, Japan.
AD  - Department of Physiology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
FAU - Hosoya, Toshihiko
AU  - Hosoya T
AUID- ORCID: 0000-0001-8559-8344
AD  - RIKEN Center for Brain Science and RIKEN Brain Science Institute, Wako-shi, 
      Saitama, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201106
PL  - United States
TA  - PLoS Comput Biol
JT  - PLoS computational biology
JID - 101238922
SB  - IM
MH  - Action Potentials/*physiology
MH  - Animals
MH  - Light
MH  - Models, Biological
MH  - Neurons/physiology
MH  - Photic Stimulation
MH  - Retina/cytology/*physiology
MH  - Urodela
PMC - PMC7738174
COIS- The authors have declared that no competing interests exist.
EDAT- 2020/11/07 06:00
MHDA- 2021/01/30 06:00
PMCR- 2020/11/06
CRDT- 2020/11/06 17:35
PHST- 2020/02/10 00:00 [received]
PHST- 2020/09/22 00:00 [accepted]
PHST- 2020/12/15 00:00 [revised]
PHST- 2020/11/07 06:00 [pubmed]
PHST- 2021/01/30 06:00 [medline]
PHST- 2020/11/06 17:35 [entrez]
PHST- 2020/11/06 00:00 [pmc-release]
AID - PCOMPBIOL-D-20-00205 [pii]
AID - 10.1371/journal.pcbi.1007726 [doi]
PST - epublish
SO  - PLoS Comput Biol. 2020 Nov 6;16(11):e1007726. doi: 10.1371/journal.pcbi.1007726. 
      eCollection 2020 Nov.