PMID- 33157433
OWN - NLM
STAT- MEDLINE
DCOM- 20211008
LR  - 20230101
IS  - 1879-3320 (Electronic)
IS  - 0960-7404 (Linking)
VI  - 35
DP  - 2020 Dec
TI  - Diagnosis, pathophysiology, and treatment of SIRT-induced gastroduodenal ulcers: 
      A systematic literature review.
PG  - 520-526
LID - S0960-7404(20)30422-9 [pii]
LID - 10.1016/j.suronc.2020.10.014 [doi]
AB  - BACKGROUND: Selective Internal Radiation Therapy (SIRT) is a therapeutic modality 
      in patients with hepatocellular carcinoma or liver metastases. Complications due 
      to SIRT-induced gastric ulcers are seen in less than 5% of patients but there is 
      no consensus for management of this rare side effect. We conducted a systematic 
      review to analyze the efficacy of medical treatment of SIRT-induced ulcers. 
      METHODS: This systematic review was conducted in accordance with the PRISMA 
      guidelines. We developed the research question following the population, 
      intervention, comparison, outcome, and study design (PICOS) format. We identified 
      studies and cases reporting patients with gastric and/or duodenal (=population) 
      ulcers treated with medical therapy with proton pump inhibitor (PPI), antacid, or 
      sucralfate, alone or in combination (=intervention). We did not require that 
      studies include a control group. We included studies reporting the evaluation of 
      the medical and/or surgical treatment (=outcomes). RESULTS: Out of 219 articles, 
      29 articles were included, resulting in analysis of data for a total of 51 
      patients who had a SIRT-induced gastric and/or duodenal ulcer treated with 
      medication, surgery, or both. Twenty-eight patients (55%) were reported to have 
      SIRT-induced ulcers that improved after initiation of PPI, antacid, or sucralfate 
      treatment (alone or in combination). Twenty-three patients (45%) were reported to 
      be refractory to medical treatment and surgery was performed in 7 out of 23 
      patients (30%). CONCLUSIONS: About 45% of SIRT-induced gastroduodenal ulcers are 
      refractory to medical treatment with PPI, antacid, or sucralfate, alone or in 
      combination. Surgery is an effective treatment in patients who are refractory to 
      medical treatment and who have intense symptoms.
CI  - Copyright (c) 2020. Published by Elsevier Ltd.
FAU - Laila, Belcaid
AU  - Laila B
AD  - Department of Surgical Oncology, Belgium.
FAU - Vinciane, Ledouble
AU  - Vinciane L
AD  - Department of Medical Oncology, Belgium.
FAU - Michael, Vouche
AU  - Michael V
AD  - Department of Radiology, Belgium.
FAU - Patrick, Flamen
AU  - Patrick F
AD  - Department of Nuclear Medicine, Belgium.
FAU - Awada, Ahmad
AU  - Awada A
AD  - Department of Medical Oncology, Belgium.
FAU - Maria, Gomez Galdon
AU  - Maria GG
AD  - Department of PathologyInstitute, Institut Jules Bordet, Universite Libre de 
      Bruxelles, Brussels, Belgium.
FAU - Gabriel, Liberale
AU  - Gabriel L
AD  - Department of Surgical Oncology, Belgium. Electronic address: 
      Gabriel.liberale@bordet.be.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20201021
PL  - Netherlands
TA  - Surg Oncol
JT  - Surgical oncology
JID - 9208188
RN  - 0 (Anti-Ulcer Agents)
SB  - IM
EIN - Surg Oncol. 2023 Feb;46:101898. PMID: 36587592
MH  - Anti-Ulcer Agents/*therapeutic use
MH  - Humans
MH  - Liver Neoplasms/pathology/*radiotherapy
MH  - Peptic Ulcer/*diagnosis/*drug therapy/etiology
MH  - Radiotherapy/*adverse effects
OTO - NOTNLM
OT  - Embolization
OT  - Gastroduodenal ulcer
OT  - PRISMA
OT  - Refractory
OT  - SIRT
OT  - Surgery
EDAT- 2020/11/07 06:00
MHDA- 2021/10/09 06:00
CRDT- 2020/11/06 20:16
PHST- 2020/07/05 00:00 [received]
PHST- 2020/08/16 00:00 [revised]
PHST- 2020/10/20 00:00 [accepted]
PHST- 2020/11/07 06:00 [pubmed]
PHST- 2021/10/09 06:00 [medline]
PHST- 2020/11/06 20:16 [entrez]
AID - S0960-7404(20)30422-9 [pii]
AID - 10.1016/j.suronc.2020.10.014 [doi]
PST - ppublish
SO  - Surg Oncol. 2020 Dec;35:520-526. doi: 10.1016/j.suronc.2020.10.014. Epub 2020 Oct 
      21.