PMID- 33158796
OWN - NLM
STAT- MEDLINE
DCOM- 20211012
LR  - 20211117
IS  - 2212-2672 (Print)
IS  - 2212-2672 (Linking)
VI  - 121
IP  - 7
DP  - 2021 Jul
TI  - Dietary Patterns and the Risk of Dyslipidemia in Korean Adults: A Prospective 
      Cohort Study Based on the Health Examinees (HEXA) Study.
PG  - 1242-1257.e2
LID - S2212-2672(20)31232-6 [pii]
LID - 10.1016/j.jand.2020.08.090 [doi]
AB  - BACKGROUND: Identifying dietary patterns that contribute to dyslipidemia 
      development can inform prevention, nutritional counseling, and other treatment 
      recommendations. OBJECTIVE: This study aimed to identify major dietary patterns 
      and examine the association between these dietary patterns and dyslipidemia 
      incidence by sex among Koreans. DESIGN: The Health Examinees (HEXA) study is a 
      community-based prospective cohort study. The baseline and follow-up surveys were 
      conducted in 2004-2013, and 2012-2016, respectively, at 38 health examination 
      centers and training hospitals located in eight regions in Korea. Dietary intake 
      data were collected using a web-based, validated semiquantitative food frequency 
      questionnaire (FFQ) at baseline. PARTICIPANTS/SETTING: Among 65,642 participants 
      who completed the baseline and follow-up survey, data from 38,170 participants 
      without dyslipidemia and other related chronic diseases at baseline were 
      analyzed. MAIN OUTCOME MEASURES: Incidence of dyslipidemia and its components 
      (hypercholesterolemia, hyper-low-density lipoprotein [LDL] cholesterolemia, 
      hypo-high-density lipoprotein [HDL] cholesterolemia, and hypertriglyceridemia) 
      after baseline but before the follow-up examination was examined. STATISTICAL 
      ANALYSES: Factor analysis was conducted on data from the semiquantitative FFQ to 
      identify major dietary patterns for Korean adults. Cox proportional hazards 
      regression analysis was performed to estimate the relative risk (RR) and 95% 
      confidence interval (CI) according to the quintiles of three dietary pattern 
      scores, after adjusting for potential confounders by sex. RESULTS: Of the three 
      identified dietary patterns, the higher "prudent" pattern score was associated 
      with a lower incidence of dyslipidemia (RR, 0.90; 95% CI, 0.82-0.99; P = .02) 
      after adjusting for potential confounders in women. Higher "flour-based food and 
      meats" pattern score was associated with a higher incidence of 
      hypercholesterolemia (men: RR, 1.63; 95% CI, 1.21-2.20; P = .003; women: RR, 
      1.47; 95% CI, 1.30-1.67; P < .001), hyper-LDL cholesterolemia (men: RR, 1.45; 95% 
      CI, 1.03-2.04, P = .06; women: RR, 1.35; 95% CI, 1.16-1.58, P < .001), and 
      dyslipidemia (men: RR, 1.30; 95% CI, 1.09-1.54; P = .009; women: RR, 1.28; 95% 
      CI, 1.16-1.42; P < .001) in both men and women. The "white rice" pattern score 
      was associated with a lower incidence of hypo-HDL cholesterolemia (RR, 0.75; 95% 
      CI, 0.58-0.96; P = .01) and dyslipidemia (RR, 0.90; 95% CI, 0.81-0.99; P = .07) 
      in women. CONCLUSIONS: Adherence to the "prudent" and "white rice" patterns was 
      associated with a lower dyslipidemia risk in Korean women, whereas adherence to 
      the "flour-based food and meats" pattern was associated with increased risks of 
      dyslipidemia and its components (hypercholesterolemia and hyper-LDL 
      cholesterolemia) in both Korean men and women.
CI  - Copyright (c) 2021 Academy of Nutrition and Dietetics. Published by Elsevier Inc. 
      All rights reserved.
FAU - Kim, Seong-Ah
AU  - Kim SA
AD  - Department of Food and Nutrition, Chung-Ang University, Gyeonggi-do, Korea.
FAU - Shin, Sangah
AU  - Shin S
AD  - Department of Food and Nutrition, Chung-Ang University, Gyeonggi-do, Korea. 
      Electronic address: ivory8320@cau.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201103
PL  - United States
TA  - J Acad Nutr Diet
JT  - Journal of the Academy of Nutrition and Dietetics
JID - 101573920
RN  - 0 (Cholesterol, LDL)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cholesterol, LDL/blood
MH  - Diet/*adverse effects/*statistics & numerical data
MH  - Diet Surveys
MH  - Dyslipidemias/*epidemiology/*etiology
MH  - Factor Analysis, Statistical
MH  - Feeding Behavior
MH  - Female
MH  - Health Surveys
MH  - Humans
MH  - Hypercholesterolemia/epidemiology/etiology
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Republic of Korea/epidemiology
MH  - Risk Assessment
MH  - Risk Factors
MH  - Sex Factors
OTO - NOTNLM
OT  - Dyslipidemia
OT  - Hyper-low-density lipoprotein cholesterolemia
OT  - Hypercholesterolemia
OT  - Hypertriglyceridemia
OT  - Hypo-high-density lipoprotein cholesterolemia
OT  - dietary patterns
EDAT- 2020/11/08 06:00
MHDA- 2021/10/13 06:00
CRDT- 2020/11/07 05:28
PHST- 2020/02/05 00:00 [received]
PHST- 2020/08/19 00:00 [revised]
PHST- 2020/08/24 00:00 [accepted]
PHST- 2020/11/08 06:00 [pubmed]
PHST- 2021/10/13 06:00 [medline]
PHST- 2020/11/07 05:28 [entrez]
AID - S2212-2672(20)31232-6 [pii]
AID - 10.1016/j.jand.2020.08.090 [doi]
PST - ppublish
SO  - J Acad Nutr Diet. 2021 Jul;121(7):1242-1257.e2. doi: 10.1016/j.jand.2020.08.090. 
      Epub 2020 Nov 3.