PMID- 33160154
OWN - NLM
STAT- MEDLINE
DCOM- 20211206
LR  - 20211214
IS  - 1879-0054 (Electronic)
IS  - 0739-7240 (Linking)
VI  - 74
DP  - 2021 Jan
TI  - Maternal nutrient restriction alters endocrine pancreas development in fetal 
      heifers.
PG  - 106580
LID - S0739-7240(20)30147-8 [pii]
LID - 10.1016/j.domaniend.2020.106580 [doi]
AB  - Maternal nutrient restriction during pregnancy alters fetal programming, which 
      modifies the growth and health of the offspring in postnatal life. In cattle, 
      nutrient restriction during pregnancy can be a result of environmental or 
      economic factors, but little is known about how it alters the physiology of the 
      fetus and affects future reproductive or growth efficiency. This study used 
      female monozygotic twins, produced through in vitro fertilization and embryo 
      splitting, to determine the effect of moderate maternal nutrient restriction on 
      fetal development. Recipient Angus cross heifers pregnant with one twin were fed 
      a diet meeting 100% National Research Council (NRC) total energy requirements (n 
      = 4; control), whereas recipient heifers pregnant with the second twin were fed 
      at 70% of NRC total energy requirements (n = 4; restricted) from gestational day 
      (GD) 158 to GD 265 in Calan gate feeders. Recipient heifers were killed at GD 
      265. Change in maternal metabolic body weight was greater from zero in restricted 
      heifers than controls (P < 0.05); restricted heifers lost weight during the 
      nutrient restriction period. There was no difference in last rib back fat or rib 
      eye area between groups (P > 0.10). There was no difference in fetal weight, 
      uterine weight, or total placentome weight between groups (P > 0.10). The 
      pancreas weight was reduced in restricted fetuses compared with control fetuses 
      (P < 0.01), but there were no other differences in fetal organ weights (P > 
      0.10). Plasma insulin concentrations were reduced in restricted fetuses compared 
      with controls (P < 0.01), but there was no effect of maternal diet on plasma 
      glucose or glucagon concentrations in the fetus (P > 0.10). Histological analyses 
      of the fetal pancreas revealed no differences in endocrine cell number or 
      localization. Results indicate that a modest late gestation nutritional 
      restriction impairs development of the fetal pancreas in the cow. Additional 
      research will be needed to determine if these developmental changes lead to 
      altered glucose and insulin homeostasis in the adult.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Long, J M
AU  - Long JM
AD  - Department of Animal Science, Texas A&M University, 2471 TAMUS, College Station, 
      TX 77843, USA.
FAU - Trubenbach, L A
AU  - Trubenbach LA
AD  - Department of Animal Science, Texas A&M University, 2471 TAMUS, College Station, 
      TX 77843, USA.
FAU - Pryor, J H
AU  - Pryor JH
AD  - Department of Veterinary Physiology and Pharmacology, Texas A&M University, 
      College Station, TX 77843, USA.
FAU - Long, C R
AU  - Long CR
AD  - Department of Veterinary Physiology and Pharmacology, Texas A&M University, 
      College Station, TX 77843, USA.
FAU - Wickersham, T A
AU  - Wickersham TA
AD  - Department of Animal Science, Texas A&M University, 2471 TAMUS, College Station, 
      TX 77843, USA.
FAU - Sawyer, J E
AU  - Sawyer JE
AD  - King Ranch(R) Institute for Ranch Management, Texas A&M University - Kingsville, 
      Kingsville, TX 78363, USA.
FAU - Satterfield, M C
AU  - Satterfield MC
AD  - Department of Animal Science, Texas A&M University, 2471 TAMUS, College Station, 
      TX 77843, USA. Electronic address: csatterfield@tamu.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201010
PL  - United States
TA  - Domest Anim Endocrinol
JT  - Domestic animal endocrinology
JID - 8505191
RN  - 0 (Insulin)
SB  - IM
MH  - Animal Feed/*analysis
MH  - Animal Nutritional Physiological Phenomena
MH  - Animals
MH  - Cattle/*embryology
MH  - Diet/*veterinary
MH  - Embryo Culture Techniques
MH  - Embryo Transfer
MH  - Female
MH  - Fetal Development
MH  - Food Deprivation
MH  - Insulin/*metabolism
MH  - Pancreas/*embryology/metabolism
MH  - Pregnancy
MH  - Prenatal Nutritional Physiological Phenomena
MH  - Twinning, Monozygotic
OTO - NOTNLM
OT  - Bovine
OT  - Insulin
OT  - Nutrient restriction
OT  - Pancreas
OT  - Pregnancy
EDAT- 2020/11/08 06:00
MHDA- 2021/12/15 06:00
CRDT- 2020/11/07 20:12
PHST- 2020/07/01 00:00 [received]
PHST- 2020/09/24 00:00 [revised]
PHST- 2020/10/02 00:00 [accepted]
PHST- 2020/11/08 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2020/11/07 20:12 [entrez]
AID - S0739-7240(20)30147-8 [pii]
AID - 10.1016/j.domaniend.2020.106580 [doi]
PST - ppublish
SO  - Domest Anim Endocrinol. 2021 Jan;74:106580. doi: 10.1016/j.domaniend.2020.106580. 
      Epub 2020 Oct 10.