PMID- 33161043
OWN - NLM
STAT- MEDLINE
DCOM- 20210618
LR  - 20210618
IS  - 1873-4596 (Electronic)
IS  - 0891-5849 (Linking)
VI  - 162
DP  - 2021 Jan
TI  - Hyperoside from Z. bungeanum leaves restores insulin secretion and mitochondrial 
      function by regulating pancreatic cellular redox status in diabetic mice.
PG  - 412-422
LID - S0891-5849(20)31594-X [pii]
LID - 10.1016/j.freeradbiomed.2020.10.320 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is characterized by peripheral insulin resistance 
      and insufficient insulin secretion caused by pancreatic beta-cell dysfunction. 
      Excessive production of reactive oxygen species (ROS) and activation of caspases 
      in mitochondria inhibit insulin secretion and promote apoptosis of pancreatic 
      beta-cells. Studies have demonstrated that positive correlation between the 
      consumption of flavonoid-rich diets and diabetes prevention. Zanthoxylum 
      bungeanum leaves have been used as food for a long time and are rich in 
      flavonoids with strong radical scavenging abilities. We and others have 
      identified hyperoside as the major bioactive component of total flavonoids 
      exacted from Zanthoxylum bungeanum leaves. We hypothesize that hyperoside from Z. 
      bungeanum leaves (HZL) may prevent T2DM by inhibiting excessive ROS formation and 
      reducing pancreatic beta-cells apoptosis. In current study, HZL was administered to 
      high fat diet and alloxan-induced diabetic mice, and appeared to significantly 
      ameliorate the damage of glucose metabolism and insulin secretion as well as 
      restore the structural integrity of pancreas, and inhibit beta-cell apoptosis. 
      Pancreatic antioxidant enzyme activities were also restored by HZL 
      supplementation. In cultured MIN6 cells, which produce and secret insulin, HZL 
      treatment restored insulin secretion through inhibiting the expression of TXNIP 
      and lowering intracellular calcium concentration. These observations 
      mechanistically linked the beneficial effects of HZL with the regulation on 
      cellular redox status and mitochondrial function. Taken together, our findings 
      suggest that HZL has protective effect on pancreatic beta-cell function and may be a 
      beneficial nutritional supplementation for prevention and adjuvant therapy of 
      T2DM.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Zhang, Yali
AU  - Zhang Y
AD  - Center for Mitochondrial Biology & Medicine, The Key Laboratory of Biomedical 
      Information Engineering of Ministry of Education, School of Life Science and 
      Technology, Xi'an Jiaotong University, Xi'an, 710049, PR China.
FAU - Yu, Xiaomin
AU  - Yu X
AD  - Center for Mitochondrial Biology & Medicine, The Key Laboratory of Biomedical 
      Information Engineering of Ministry of Education, School of Life Science and 
      Technology, Xi'an Jiaotong University, Xi'an, 710049, PR China.
FAU - Wang, Mimi
AU  - Wang M
AD  - Center for Mitochondrial Biology & Medicine, The Key Laboratory of Biomedical 
      Information Engineering of Ministry of Education, School of Life Science and 
      Technology, Xi'an Jiaotong University, Xi'an, 710049, PR China.
FAU - Ding, Yan
AU  - Ding Y
AD  - Center for Mitochondrial Biology & Medicine, The Key Laboratory of Biomedical 
      Information Engineering of Ministry of Education, School of Life Science and 
      Technology, Xi'an Jiaotong University, Xi'an, 710049, PR China.
FAU - Guo, Hui
AU  - Guo H
AD  - Department of Endocrinology, First Affiliated Hospital of Medical College, Xi'an 
      Jiaotong University, Xi'an, 710061, PR China.
FAU - Liu, Jiankang
AU  - Liu J
AD  - Center for Mitochondrial Biology & Medicine, The Key Laboratory of Biomedical 
      Information Engineering of Ministry of Education, School of Life Science and 
      Technology, Xi'an Jiaotong University, Xi'an, 710049, PR China.
FAU - Cheng, Ying
AU  - Cheng Y
AD  - Center for Mitochondrial Biology & Medicine, The Key Laboratory of Biomedical 
      Information Engineering of Ministry of Education, School of Life Science and 
      Technology, Xi'an Jiaotong University, Xi'an, 710049, PR China. Electronic 
      address: yingcheng@xjtu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201105
PL  - United States
TA  - Free Radic Biol Med
JT  - Free radical biology & medicine
JID - 8709159
RN  - 0 (Insulin)
RN  - 8O1CR18L82 (hyperoside)
RN  - 9IKM0I5T1E (Quercetin)
SB  - IM
MH  - Animals
MH  - *Diabetes Mellitus, Experimental/drug therapy/metabolism
MH  - *Diabetes Mellitus, Type 2/drug therapy/metabolism
MH  - Insulin/metabolism
MH  - Insulin Secretion
MH  - *Insulin-Secreting Cells
MH  - Mice
MH  - Mitochondria
MH  - Oxidation-Reduction
MH  - Plant Leaves/metabolism
MH  - Quercetin/analogs & derivatives
OTO - NOTNLM
OT  - Hyperoside
OT  - Mitochondria
OT  - Pancreatic beta-cell
OT  - ROS
OT  - Z. bungeanum leaves
EDAT- 2020/11/09 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/11/08 20:27
PHST- 2020/05/23 00:00 [received]
PHST- 2020/08/19 00:00 [revised]
PHST- 2020/10/27 00:00 [accepted]
PHST- 2020/11/09 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/11/08 20:27 [entrez]
AID - S0891-5849(20)31594-X [pii]
AID - 10.1016/j.freeradbiomed.2020.10.320 [doi]
PST - ppublish
SO  - Free Radic Biol Med. 2021 Jan;162:412-422. doi: 
      10.1016/j.freeradbiomed.2020.10.320. Epub 2020 Nov 5.