PMID- 33161057
OWN - NLM
STAT- MEDLINE
DCOM- 20210125
LR  - 20210125
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 768
DP  - 2021 Feb 5
TI  - SLC30A8 gene polymorphism rs13266634 associated with increased risk for 
      developing type 2 diabetes mellitus in Jordanian population.
PG  - 145279
LID - S0378-1119(20)30948-3 [pii]
LID - 10.1016/j.gene.2020.145279 [doi]
AB  - BACKGROUND: Several genome-wide association studies (GWAS) have identified the 
      single nucleotide polymorphism (SNP) rs13266634 in the Solute carrier family 30 
      member 8 (SLC30A8) gene as a risk factor to type 2 diabetes mellitus (T2DM). 
      Nevertheless, other studies reported controversial findings of no significant 
      association between the rs13266634 with T2DM. In this study, we aimed to 
      investigate the association of this SNP with T2DM among Jordanian population in 
      addition to define its corresponding allelic and genotypic frequencies. METHOD: 
      This case-control study enrolled 358 T2DM patients and 326 healthy controls who 
      fulfilled the inclusion criteria. Blood samples were collected from all 
      participants and were used for the rs13266634 SNP genotyping by polymerase chain 
      reaction-restriction fragment length polymorphism (PCR-RFLP) technique. RESULTS: 
      We demonstrated a significant association between the C/T rs13266634 SNP and T2DM 
      among Jordanian population. A significant difference was found between the cases 
      and controls regarding the allelic (P = 0.003) distribution. Compared to people 
      having T allele, those with C allele had higher risk of T2DM (OR = 1.47 ; 95% CI: 
      1.14 - 1.89; P = 0.003). Having a CC genotype versus TT genotype was 
      significantly associated with increased risk to T2DM (OR = 2.44; 95% CI: 1.16 - 
      5.12; P = 0.019) after adjusting for age, gender, and BMI. Under the recessive 
      model, subjects with CC genotype were more likely to have T2DM compared to those 
      with CT or TT genotypes, (OR = 1.64; 95% CI: 1.18 - 2.26; P = 0.003) after 
      adjusting for age, gender and BMI. CONCLUSION: The rs13266634 SNP is 
      significantly associated with T2DM susceptibility among Jordanian Population.
CI  - Copyright (c) 2020. Published by Elsevier B.V.
FAU - Mashal, Safaa
AU  - Mashal S
AD  - Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, 
      University of Jordan, PO Box: 13617, Queen Rania St., Amman 11942, Jordan.
FAU - Khanfar, Mariam
AU  - Khanfar M
AD  - Department of Medical Laboratory Sciences, Jordan University of Science and 
      Technology, P.O.Box 3030, Irbid 22110, Jordan.
FAU - Al-Khalayfa, Sawsan
AU  - Al-Khalayfa S
AD  - Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, 
      University of Jordan, PO Box: 13617, Queen Rania St., Amman 11942, Jordan.
FAU - Srour, Luma
AU  - Srour L
AD  - Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, 
      University of Jordan, PO Box: 13617, Queen Rania St., Amman 11942, Jordan.
FAU - Mustafa, Lina
AU  - Mustafa L
AD  - Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, 
      University of Jordan, PO Box: 13617, Queen Rania St., Amman 11942, Jordan.
FAU - Hakooz, Nancy M
AU  - Hakooz NM
AD  - Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, 
      University of Jordan, PO Box: 13617, Queen Rania St., Amman 11942, Jordan.
FAU - Zayed, Ayman A
AU  - Zayed AA
AD  - Division of Endocrinology, Diabetes, and Metabolism, Department of Internal 
      Medicine, School of Medicine, The University of Jordan, Jordan University 
      Hospital, PO Box: 13617, Queen Rania St., Amman 11942, Jordan.
FAU - Khader, Yousef S
AU  - Khader YS
AD  - Department of Community Medicine, Public Health and Family Medicine, Faculty of 
      Medicine, Jordan University of Science and Technology, P.O.Box 3030, Irbid 22110, 
      Jordan.
FAU - Azab, Bilal
AU  - Azab B
AD  - Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, 
      University of Jordan, PO Box: 13617, Queen Rania St., Amman 11942, Jordan; 
      Department of Human and Molecular Genetics, School of Medicine, Virginia 
      Commonwealth University, United States. Electronic address: 
      azabbm@mymail.vcu.edu.
LA  - eng
PT  - Journal Article
DEP - 20201105
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (SLC30A8 protein, human)
RN  - 0 (Zinc Transporter 8)
SB  - IM
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genome-Wide Association Study
MH  - Genotype
MH  - Humans
MH  - Jordan
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Restriction Fragment Length/genetics
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Zinc Transporter 8/*genetics
OTO - NOTNLM
OT  - Polymerase chain reaction-restriction fragment length polymorphism
OT  - SLC30A8
OT  - Solute carrier family 30 member 8
OT  - Type 2 diabetes mellitus
OT  - rs13266634
EDAT- 2020/11/09 06:00
MHDA- 2021/01/26 06:00
CRDT- 2020/11/08 20:27
PHST- 2020/07/01 00:00 [received]
PHST- 2020/10/08 00:00 [revised]
PHST- 2020/10/23 00:00 [accepted]
PHST- 2020/11/09 06:00 [pubmed]
PHST- 2021/01/26 06:00 [medline]
PHST- 2020/11/08 20:27 [entrez]
AID - S0378-1119(20)30948-3 [pii]
AID - 10.1016/j.gene.2020.145279 [doi]
PST - ppublish
SO  - Gene. 2021 Feb 5;768:145279. doi: 10.1016/j.gene.2020.145279. Epub 2020 Nov 5.