PMID- 33161597
OWN - NLM
STAT- MEDLINE
DCOM- 20211028
LR  - 20211028
IS  - 1096-9101 (Electronic)
IS  - 0196-8092 (Linking)
VI  - 53
IP  - 5
DP  - 2021 Jul
TI  - Adverse Events of Intense Pulsed Light Combined With Meibomian Gland Expression 
      Versus Meibomian Gland Expression in the Treatment of Meibomian Gland 
      Dysfunction.
PG  - 664-670
LID - 10.1002/lsm.23339 [doi]
AB  - BACKGROUND AND OBJECTIVE: To analyze the occurrence and causes of adverse events 
      (AEs) in intense pulsed light (IPL) combined with meibomian gland expression 
      (MGX) and MGX treatment alone for meibomian gland dysfunction (MGD). STUDY 
      DESIGN/MATERIALS AND METHODS: A retrospective study was conducted on MGD patients 
      treated in Wuhan Aier Hankou Eye Hospital from February 2018 to October 2019 to 
      compare the AEs between IPL-MGX and MGX groups. Relevant AEs that occurred during 
      the treatment and within 1 month after the patients' last treatment were recorded 
      and the causes of the AEs were analyzed. RESULTS: A total of 2,282 patients 
      received IPL-MGX and 1,407 received MGX treatment. No serious AEs occurred in 
      both groups. There were 74 AEs in the IPL-MGX group, with an incidence of 3.24%, 
      including 14 significant AEs (2 cases of epidemic keratoconjunctivitis, 1 
      recurrent herpes simplex keratitis (HSK), 9 new onsets of floaters, 1 recurrent 
      glaucomatocyclitic crises, and 1 recurrent iridocyclitis). There were 27 AEs in 
      the MGX group with a rate of 1.92%, including 4 significant AEs (2 cases of 
      keratoconjunctivitis epidemic, 2 new cases of floaters). Compared with the 
      IPL-MGX group, the incidence of AEs in the MGX group was lower (P = 0.017). 
      CONCLUSIONS: Both IPL-MGX and MGX treatment are safe therapies with low risk for 
      AEs. IPL treatment is not recommended for young children (age 10 or less) as well 
      as patients with anterior uveitis or glaucomatocyclitic crises. The previous 
      history of HSK and eyes with high myopia are advised to exercise caution in IPL 
      treatment. Lasers Surg. Med. (c) 2020 Wiley Periodicals LLC.
CI  - (c) 2020 Wiley Periodicals LLC.
FAU - Qiao, Chen
AU  - Qiao C
AUID- ORCID: 0000-0001-9589-1085
AD  - Aier Eye Hospital of Wuhan University, Wuhan, Hubei, 430063, China.
AD  - Department of Cornea & Ocular Surface Diseases, Wuhan Aier Hankou Eye Hospital, 
      Wuhan, Hubei, 430024, China.
FAU - Li, Liping
AU  - Li L
AD  - Department of Cornea & Ocular Surface Diseases, Wuhan Aier Hankou Eye Hospital, 
      Wuhan, Hubei, 430024, China.
FAU - Wang, Haoyu
AU  - Wang H
AD  - Department of Cornea & Ocular Surface Diseases, Wuhan Aier Hankou Eye Hospital, 
      Wuhan, Hubei, 430024, China.
FAU - Zhao, Cong
AU  - Zhao C
AD  - Department of Cornea & Ocular Surface Diseases, Wuhan Aier Hankou Eye Hospital, 
      Wuhan, Hubei, 430024, China.
FAU - Ke, Lan
AU  - Ke L
AD  - Aier Eye Hospital of Wuhan University, Wuhan, Hubei, 430063, China.
AD  - Department of Cornea & Ocular Surface Diseases, Wuhan Aier Hankou Eye Hospital, 
      Wuhan, Hubei, 430024, China.
FAU - Sen, Dan
AU  - Sen D
AD  - Department of Cornea & Ocular Surface Diseases, Wuhan Aier Hankou Eye Hospital, 
      Wuhan, Hubei, 430024, China.
FAU - Qi, Mengying
AU  - Qi M
AD  - Department of Cornea & Ocular Surface Diseases, Wuhan Aier Hankou Eye Hospital, 
      Wuhan, Hubei, 430024, China.
FAU - Li, Shaowei
AU  - Li S
AD  - Aier Cornea Institute, Beijing, 100021, China.
FAU - Wang, Mingwu
AU  - Wang M
AD  - Aier Cornea Institute, Beijing, 100021, China.
AD  - Department of Ophthalmology and Vision Science, University of Arizona College of 
      Medicine, Tucson, 85711, Arizona.
FAU - Zeng, Qingyan
AU  - Zeng Q
AD  - Aier Eye Hospital of Wuhan University, Wuhan, Hubei, 430063, China.
AD  - Department of Cornea & Ocular Surface Diseases, Wuhan Aier Hankou Eye Hospital, 
      Wuhan, Hubei, 430024, China.
AD  - Aier Cornea Institute, Beijing, 100021, China.
LA  - eng
GR  - AR1904D2/Projects of Aier Eye Group/
GR  - WX18Q46/Health and Family Planning Commission of Wuhan Municipality/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201108
PL  - United States
TA  - Lasers Surg Med
JT  - Lasers in surgery and medicine
JID - 8007168
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - *Intense Pulsed Light Therapy/adverse effects
MH  - *Meibomian Gland Dysfunction
MH  - Meibomian Glands
MH  - Phototherapy
MH  - Retrospective Studies
OTO - NOTNLM
OT  - adverse event
OT  - intense pulsed light
OT  - meibomian gland dysfunction
OT  - meibomian gland expression
EDAT- 2020/11/09 06:00
MHDA- 2021/10/29 06:00
CRDT- 2020/11/08 20:38
PHST- 2020/08/27 00:00 [revised]
PHST- 2020/07/02 00:00 [received]
PHST- 2020/10/08 00:00 [accepted]
PHST- 2020/11/09 06:00 [pubmed]
PHST- 2021/10/29 06:00 [medline]
PHST- 2020/11/08 20:38 [entrez]
AID - 10.1002/lsm.23339 [doi]
PST - ppublish
SO  - Lasers Surg Med. 2021 Jul;53(5):664-670. doi: 10.1002/lsm.23339. Epub 2020 Nov 8.