PMID- 33162245
OWN - NLM
STAT- MEDLINE
DCOM- 20210527
LR  - 20210527
IS  - 1873-3336 (Electronic)
IS  - 0304-3894 (Linking)
VI  - 406
DP  - 2021 Mar 15
TI  - Emerging POPs-type cocktail signatures in Pusa caspica in quantitative 
      structure-activity relationship of Caspian Sea.
PG  - 124334
LID - S0304-3894(20)32324-4 [pii]
LID - 10.1016/j.jhazmat.2020.124334 [doi]
AB  - The Caspian seal Pusa caspica is the only endemic mammalian species throughout 
      the Caspian Sea. This is the first report on risk assessment of persistent 
      organic pollutants (POPs) in Caspian seals by age-sex and tissue-specific uptake, 
      and their surrounding environment (seawater, surface sediments, and suspended 
      particulate matters, SPMs) in the Gorgan Bay (Caspian Sea, Iran). Among the 
      quantified 70 POPs ( summation operator(35)PCBs,  summation operator(3)HCHs,  summation operator(6)CHLs,  summation operator(6)DDTs,  summation operator(17)PCDD/Fs, HCB, 
      dieldrin, and aldrin),  summation operator(35)PCBs were dominant in abiotic matrices (48.80% of 
       summation operator(70)POPs), followed by HCHs > CHLs > DDTs > PCDD/Fs > other POPs in surface 
      sediments > SPMs > seawater, while the toxic equivalent quantity (TEQ(WHO)) 
      exceeded the safe value (possible risk in this area). In biota, the highest 
      levels of  summation operator(70)POPs were found in males (756.3 ng g(-1) dw, p < 0.05), followed 
      by females (419.0 ng g(-1) dw) and pups ((1)91.6 ng g(-1) dw) in 
      liver > kidney > muscle > blubber > intestine > fur > heart > spleen > brain. The 
      positive age-related POPs declining correlation between mother-pup pairs 
      suggested the possible maternal transfer of POPs to offspring. The cocktail 
      toxicity assessment revealed that Caspian seals can pose a low risk based on 
      their mixed-TEQ values. Self-organizing map (SOM) indicated the non-coplanar 
      PCB-93 as the most over-represented functional congener in tissue-specific POPs 
      bioaccumulation. Quantitative toxicant tissue-profiling is valuable for 
      predicting the state of mixture toxicity in pinniped species.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Ranjbar Jafarabadi, Ali
AU  - Ranjbar Jafarabadi A
AD  - Department of Environmental Sciences, Faculty of Natural Resources and Marine 
      Sciences, Tarbiat Modares University, Noor, Mazandaran, Iran.
FAU - Mashjoor, Sakineh
AU  - Mashjoor S
AD  - Department of Marine Biology, Faculty of Marine Science and Technology, 
      University of Hormozgan, Bandar Abbas, Iran.
FAU - Mohamadjafari Dehkordi, Shirin
AU  - Mohamadjafari Dehkordi S
AD  - Department of Environmental Sciences, Faculty of Natural Resources and Marine 
      Sciences, Tarbiat Modares University, Noor, Mazandaran, Iran.
FAU - Riyahi Bakhtiari, Alireza
AU  - Riyahi Bakhtiari A
AD  - Department of Environmental Sciences, Faculty of Natural Resources and Marine 
      Sciences, Tarbiat Modares University, Noor, Mazandaran, Iran. Electronic address: 
      ali.ranjbar@modares.ac.ir.
FAU - Cappello, Tiziana
AU  - Cappello T
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, Messina, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201031
PL  - Netherlands
TA  - J Hazard Mater
JT  - Journal of hazardous materials
JID - 9422688
RN  - 0 (Dibenzofurans)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Water Pollutants, Chemical)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Caspian Sea
MH  - Dibenzofurans
MH  - Environmental Monitoring
MH  - *Environmental Pollutants/analysis
MH  - Female
MH  - Iran
MH  - Male
MH  - *Polychlorinated Biphenyls/analysis
MH  - *Polychlorinated Dibenzodioxins/analysis
MH  - Quantitative Structure-Activity Relationship
MH  - *Water Pollutants, Chemical/analysis
OTO - NOTNLM
OT  - Caspian Sea
OT  - Marine mammals
OT  - Mixture toxicity
OT  - Organo-chlorine pesticides
OT  - Polychlorinated biphenyls
OT  - Self-organizing map
EDAT- 2020/11/10 06:00
MHDA- 2021/05/28 06:00
CRDT- 2020/11/09 05:27
PHST- 2020/06/17 00:00 [received]
PHST- 2020/10/17 00:00 [revised]
PHST- 2020/10/17 00:00 [accepted]
PHST- 2020/11/10 06:00 [pubmed]
PHST- 2021/05/28 06:00 [medline]
PHST- 2020/11/09 05:27 [entrez]
AID - S0304-3894(20)32324-4 [pii]
AID - 10.1016/j.jhazmat.2020.124334 [doi]
PST - ppublish
SO  - J Hazard Mater. 2021 Mar 15;406:124334. doi: 10.1016/j.jhazmat.2020.124334. Epub 
      2020 Oct 31.