PMID- 33162376
OWN - NLM
STAT- MEDLINE
DCOM- 20210917
LR  - 20221207
IS  - 2095-4964 (Print)
VI  - 19
IP  - 1
DP  - 2021 Jan
TI  - Remission of new-onset type 2 diabetes mellitus in an adolescent using an 
      integrative medicine approach: A case report.
PG  - 85-88
LID - S2095-4964(20)30121-7 [pii]
LID - 10.1016/j.joim.2020.10.005 [doi]
AB  - Among adolescents, the incidence of type 2 diabetes mellitus (T2DM) has recently 
      increased. A 12-year-old Chinese boy with a one-year history of hyperphagia 
      presented to our clinic. The patient was diagnosed with T2DM one month prior to 
      visiting the clinic and reported undergoing no pharmacologic treatment. Using an 
      integrative medicine approach, including Chinese herbal decoction, berberine 
      hydrochloride tablets, physical exercise and diet control, the patient's fasting 
      blood glucose (FBG) decreased from 8.3 mmol/L to 5.5 mmol/L. Additionally, his 
      glycated haemoglobin decreased from 12.9% to 6.1%, indicating that without any 
      Western medicine intervention his diabetes has been reversed after six months of 
      treatment. His FBG remained normal, and nine months after completion of treatment 
      it was 4.9 mmol/L. A potential mechanism in this response may be related to 
      improved insulin resistance and beta-cell function, as indicated by observed changes 
      in homeostasis model assessment of insulin resistance and beta-cell function. 
      Further, weight loss may also have contributed to the effectiveness of the 
      treatment. This case study is the first to present the innovative approach of 
      integrative medicine to achieve remission of new-onset adolescent T2DM.
CI  - Copyright (c) 2020 Shanghai Changhai Hospital. Published by Elsevier B.V. All 
      rights reserved.
FAU - Shao, Baoyi
AU  - Shao B
AD  - Clinical Division, Beijing Changchun Hospital of Traditional Chinese Medicine, 
      Beijing 100123, China.
FAU - Hou, Saiying
AU  - Hou S
AD  - Clinical Division, Beijing Changchun Hospital of Traditional Chinese Medicine, 
      Beijing 100123, China.
FAU - Chan, Yuenyan
AU  - Chan Y
AD  - Clinical Division, Beijing Changchun Hospital of Traditional Chinese Medicine, 
      Beijing 100123, China.
FAU - Shao, Changchun
AU  - Shao C
AD  - Clinical Division, Beijing Changchun Hospital of Traditional Chinese Medicine, 
      Beijing 100123, China. Electronic address: shaochangchun1965@126.com.
FAU - Lao, Lixing
AU  - Lao L
AD  - Virginia University of Integrative Medicine, Fairfax, VA 2203, USA. Electronic 
      address: llao@vuim.edu.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20201022
PL  - Netherlands
TA  - J Integr Med
JT  - Journal of integrative medicine
JID - 101603118
RN  - 0 (Blood Glucose)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0I8Y3P32UF (Berberine)
SB  - IM
MH  - Berberine/therapeutic use
MH  - Blood Glucose
MH  - Child
MH  - *Diabetes Mellitus, Type 2/therapy
MH  - Diet
MH  - Drugs, Chinese Herbal/therapeutic use
MH  - Exercise
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Insulin
MH  - *Integrative Medicine
MH  - Male
MH  - Remission Induction
OTO - NOTNLM
OT  - Case report
OT  - Integrative medicine
OT  - Traditional Chinese medicine
OT  - Type 2 diabetes mellitus
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/11/10 06:00
MHDA- 2021/09/18 06:00
CRDT- 2020/11/09 05:28
PHST- 2020/06/05 00:00 [received]
PHST- 2020/08/28 00:00 [accepted]
PHST- 2020/11/10 06:00 [pubmed]
PHST- 2021/09/18 06:00 [medline]
PHST- 2020/11/09 05:28 [entrez]
AID - S2095-4964(20)30121-7 [pii]
AID - 10.1016/j.joim.2020.10.005 [doi]
PST - ppublish
SO  - J Integr Med. 2021 Jan;19(1):85-88. doi: 10.1016/j.joim.2020.10.005. Epub 2020 
      Oct 22.