PMID- 33162484 OWN - NLM STAT- MEDLINE DCOM- 20210416 LR - 20210519 IS - 1349-7235 (Electronic) IS - 0918-2918 (Print) IS - 0918-2918 (Linking) VI - 60 IP - 8 DP - 2021 Apr 15 TI - Clinical Manifestations of Allergic Bronchopulmonary Aspergillosis without Major Features of Asthma Diagnosed by the New Criteria in Japan. PG - 1251-1255 LID - 10.2169/internalmedicine.6072-20 [doi] AB - Allergic bronchopulmonary aspergillosis (ABPA) is a severe form of asthma in which structural airway destruction occurs due to a hypersensitivity reaction to fungi. A 25-year-old man without any major features of asthma had lung infiltration with dilatation of the central bronchus, high-attenuation mucus with histological eosinophilic invasion, fungi detected on cultures, and positive Aspergillus-specific immunoglobulin E (IgE) and precipitating antibody of Aspergillus, with a significant elevation of blood eosinophils and slightly increased total IgE. He recovered rapidly with systemic corticosteroid therapy without recurrence over 1-year follow-up and an increased forced expiratory volume in one second, which supported the possibility of ABPA without any major features of asthma. FAU - Kurihara, Yuki AU - Kurihara Y AD - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan. FAU - Tashiro, Hiroki AU - Tashiro H AD - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan. FAU - Takahashi, Koichiro AU - Takahashi K AD - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan. FAU - Komiya, Natsuko AU - Komiya N AD - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan. FAU - Sadamatsu, Hironori AU - Sadamatsu H AD - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan. FAU - Kimura, Shinya AU - Kimura S AD - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan. FAU - Sueoka-Aragane, Naoko AU - Sueoka-Aragane N AD - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan. LA - eng PT - Case Reports PT - Journal Article DEP - 20201109 PL - Japan TA - Intern Med JT - Internal medicine (Tokyo, Japan) JID - 9204241 RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Adult MH - *Aspergillosis, Allergic Bronchopulmonary/diagnosis/drug therapy MH - Aspergillus fumigatus MH - *Asthma/diagnosis MH - Eosinophils MH - Humans MH - Immunoglobulin E MH - Japan/epidemiology MH - Male PMC - PMC8112978 OTO - NOTNLM OT - ABPA OT - ABPM OT - allergic bronchopulmonary OT - allergic bronchopulmonary aspergillosis OT - asthma OT - diagnostic criteria COIS- Author's disclosure of potential Conflicts of Interest (COI). Koichiro Takahashi: Honoraria, Nippon Boehringer Ingelheim and Astrazeneca; Research funding, Nippon Boehringer Ingelheim. EDAT- 2020/11/10 06:00 MHDA- 2021/04/17 06:00 PMCR- 2021/04/15 CRDT- 2020/11/09 05:29 PHST- 2020/11/10 06:00 [pubmed] PHST- 2021/04/17 06:00 [medline] PHST- 2020/11/09 05:29 [entrez] PHST- 2021/04/15 00:00 [pmc-release] AID - 10.2169/internalmedicine.6072-20 [doi] PST - ppublish SO - Intern Med. 2021 Apr 15;60(8):1251-1255. doi: 10.2169/internalmedicine.6072-20. Epub 2020 Nov 9.