PMID- 33162810
OWN - NLM
STAT- MEDLINE
DCOM- 20210802
LR  - 20210802
IS  - 1449-1907 (Electronic)
IS  - 1449-1907 (Linking)
VI  - 17
IP  - 17
DP  - 2020
TI  - The PLCE1 rs2274223 variant is associated with the risk of laryngeal squamous 
      cell carcinoma.
PG  - 2826-2830
LID - 10.7150/ijms.49012 [doi]
AB  - Background: Laryngeal squamous cell carcinoma (LSCC) ranks second in the 
      mortality rate in respiratory malignant tumors and has potential similarity in 
      genomic alterations with the esophageal squamous cell carcinoma (ESCC). The PLCE1 
      rs2274223 variant is the most significant susceptibility loci identified in ESCC. 
      Whether it is also associated with LSCC susceptibility is still unclear. 
      Materials and Methods: A total of 331 LSCC patients and 349 healthy controls were 
      recruited in this study. The PLCE1 rs2274223 variant was genotyped by using the 
      Taqman SNP Genotyping Assay. Association between PLCE1 rs2274223 variant and LSCC 
      risk was estimated by logistic regression analysis, which was performed using SAS 
      software. Results: The PLCE1 rs2274223 variant was identified to be significantly 
      associated with the susceptibility of LSCC in the additive model (OR = 1.40, 95% 
      CI: 1.06-1.86, P=0.019). Compared with the wild-type (AA) carriers, the risk 
      genotype (GG) carriers had a 2.8-fold risk of LSCC (95% CI: 1.13-7.06, P=0.026). 
      Stratified analysis showed that the association between rs2274223 and LSCC risk 
      was with higher significance in individuals above 60 (P = 0.027) males (P = 
      0.030) or non-smokers (P = 0.026). Conclusion: The PLCE1 rs2274223 variant was 
      significantly associated with risk of LSCC, which may be a potential biomarker 
      and therapeutic target for the LSCC.
CI  - (c) The author(s).
FAU - Zhang, Yi
AU  - Zhang Y
AD  - Department of Otolaryngology-Head and Neck Surgery, Beijing Chaoyang Hospital, 
      Capital Medical University, Beijing, China.
FAU - Li, Wei
AU  - Li W
AD  - The Department of Head and Neck surgery, Hubei Cancer Hospital, Wuhan, Hubei, 
      China.
FAU - Wang, Ying
AU  - Wang Y
AD  - Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing, China.
FAU - Wang, Ningyu
AU  - Wang N
AD  - Department of Otolaryngology-Head and Neck Surgery, Beijing Chaoyang Hospital, 
      Capital Medical University, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20201008
PL  - Australia
TA  - Int J Med Sci
JT  - International journal of medical sciences
JID - 101213954
RN  - 0 (Biomarkers, Tumor)
RN  - EC 3.1.4.11 (Phosphoinositide Phospholipase C)
RN  - EC 3.1.4.11 (phospholipase C epsilon)
SB  - IM
MH  - Aged
MH  - Biomarkers, Tumor/*economics
MH  - Case-Control Studies
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotyping Techniques
MH  - Humans
MH  - Laryngeal Neoplasms/diagnosis/epidemiology/*genetics/pathology
MH  - Larynx/pathology
MH  - Male
MH  - Middle Aged
MH  - Phosphoinositide Phospholipase C
MH  - Polymorphism, Single Nucleotide
MH  - Squamous Cell Carcinoma of Head and 
      Neck/diagnosis/epidemiology/*genetics/pathology
PMC - PMC7645332
OTO - NOTNLM
OT  - Laryngeal squamous cell carcinoma (LSCC)
OT  - PLCE1
OT  - rs2274223
OT  - single nucleotide polymorphism (SNP)
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2020/11/10 06:00
MHDA- 2021/08/03 06:00
PMCR- 2020/01/01
CRDT- 2020/11/09 05:30
PHST- 2020/06/02 00:00 [received]
PHST- 2020/09/16 00:00 [accepted]
PHST- 2020/11/09 05:30 [entrez]
PHST- 2020/11/10 06:00 [pubmed]
PHST- 2021/08/03 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - ijmsv17p2826 [pii]
AID - 10.7150/ijms.49012 [doi]
PST - epublish
SO  - Int J Med Sci. 2020 Oct 8;17(17):2826-2830. doi: 10.7150/ijms.49012. eCollection 
      2020.