PMID- 33162996
OWN - NLM
STAT- MEDLINE
DCOM- 20210622
LR  - 20210622
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 11
DP  - 2020
TI  - Manipulation of Regulatory Dendritic Cells for Induction Transplantation 
      Tolerance.
PG  - 582658
LID - 10.3389/fimmu.2020.582658 [doi]
LID - 582658
AB  - Current organ transplantation therapy is life-saving but accompanied by 
      well-recognized side effects due to post-transplantation systematic 
      immunosuppressive treatment. Dendritic cells (DCs) are central instigators and 
      regulators of transplantation immunity and are responsible for balancing 
      allograft rejection and tolerance. They are derived from monocyte-macrophage DC 
      progenitors originating in the bone marrow and are classified into different 
      subsets based on their developmental, phenotypical, and functional criteria. 
      Functionally, DCs instigate allograft immunity by presenting donor antigens to 
      alloreactive T cells via direct, indirect, and semidirect recognition pathways 
      and provide essential signaling for alloreactive T cell activation via 
      costimulatory molecules and pro-inflammatory cytokines. Regulatory DCs (DCregs) 
      are characterized by a relatively low expression of major histocompatibility 
      complex, costimulatory molecules, and altered cytokine production and exert their 
      regulatory function through T cell anergy, T cell deletion, and regulatory T cell 
      induction. In rodent transplantation studies, DCreg-based therapy, by in situ 
      targeting or infusion of ex vivo generated DCregs, exhibits promising potential 
      as a natural, well-tolerated, organ-specific therapeutic strategy for promoting 
      lasting organ-specific transplantation tolerance. Recent early-phase studies of 
      DCregs have begun to examine the safety and efficacy of DCreg-induced allograft 
      tolerance in living-donor renal or liver transplantations. The present review 
      summarizes the basic characteristics, function, and translation of DCregs in 
      transplantation tolerance induction.
CI  - Copyright (c) 2020 Que, Guo and Li.
FAU - Que, Weitao
AU  - Que W
AD  - Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital 
      of Zhengzhou University, Zhengzhou, China.
AD  - Division of Transplantation Immunology, National Research Institute for Child 
      Health and Development, Tokyo, Japan.
FAU - Guo, Wen-Zhi
AU  - Guo WZ
AD  - Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital 
      of Zhengzhou University, Zhengzhou, China.
FAU - Li, Xiao-Kang
AU  - Li XK
AD  - Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital 
      of Zhengzhou University, Zhengzhou, China.
AD  - Division of Transplantation Immunology, National Research Institute for Child 
      Health and Development, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20201014
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
SB  - IM
MH  - Allografts/immunology
MH  - Animals
MH  - Cell Differentiation
MH  - Dendritic Cells/*immunology
MH  - Graft Rejection/*immunology
MH  - Graft Survival
MH  - Humans
MH  - Immunomodulation
MH  - Lymphocyte Activation
MH  - *Organ Transplantation
MH  - T-Lymphocytes/*immunology
MH  - Transplantation Tolerance
PMC - PMC7591396
OTO - NOTNLM
OT  - T cell
OT  - allograft
OT  - dendritic cell
OT  - tolerance
OT  - transplantation
EDAT- 2020/11/10 06:00
MHDA- 2021/06/23 06:00
PMCR- 2020/01/01
CRDT- 2020/11/09 05:31
PHST- 2020/07/13 00:00 [received]
PHST- 2020/08/31 00:00 [accepted]
PHST- 2020/11/09 05:31 [entrez]
PHST- 2020/11/10 06:00 [pubmed]
PHST- 2021/06/23 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2020.582658 [doi]
PST - epublish
SO  - Front Immunol. 2020 Oct 14;11:582658. doi: 10.3389/fimmu.2020.582658. eCollection 
      2020.