PMID- 33163866
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220418
IS  - 2529-198X (Electronic)
IS  - 2529-198X (Linking)
VI  - 31
IP  - 3
DP  - 2020 Sep
TI  - Interstitial Pneumonia with Autoimmune Features (IPAF): A Single-Centre, 
      Prospective Study.
PG  - 330-336
LID - 10.31138/mjr.31.3.330 [doi]
AB  - OBJECTIVES: Interstitial pneumonia with autoimmune features (IPAF) refers to 
      patients with interstitial lung disease and autoimmune features not fulfilling 
      the classification criteria for a specific connective tissue disease. We sought 
      to study the characteristics, disease progression, response to treatment and 
      complications of patients with IPAF in 1-year follow-up period. METHODS: Clinical 
      and laboratory findings, comorbidities, medications, pulmonary function tests 
      (PFTs), chest HRCT and complications during the one-year follow-up period were 
      documented for each of the 39 enrolled patients with IPAF. RESULTS: The mean age 
      at the time of IPAF diagnosis was 63.2 (+/-11) years, and 62% of patients were 
      female. The most common clinical features were arthritis (82%) and rash (54%-not 
      included in the IPAF criteria). Antinuclear antibodies (ANA) (59%) and 
      non-specific interstitial pneumonia (NSIP-61.5%) were the most prevalent 
      autoantibodies and radiological pattern respectively. PFTs at 12 months from 
      baseline stabilized or improved in 79.5% of patients (p> 0.05). Infections were 
      observed in 23.1% of patients during the first and in 12.8% during the second 
      semester of follow-up. Two patients (5.1%) required hospitalization. All 
      infections occurred in patients with non-usual interstitial pneumonia (UIP) 
      pattern (p=0.02). CONCLUSIONS: Arthritis and rash are among the most common 
      features in IPAF suggesting rash could be included into IPAF criteria. Almost 80% 
      of patients had stable/improved PFTs at the end of follow-up. Infections occurred 
      mainly in the first semester of treatment and in patients with non-UIP 
      radiological pattern probably due to higher doses of corticosteroids used in 
      these patients.
CI  - (c) 2020 The Mediterranean Journal of Rheumatology (MJR).
FAU - Karampeli, Maria
AU  - Karampeli M
AD  - Department of Internal Medicine, General Hospital Korgialenio-Benakio HRC, 
      Athens, Greece.
FAU - Thomas, Konstantinos
AU  - Thomas K
AD  - 4 Department of Internal Medicine, "Attikon" University Hospital of Athens, 
      Greece.
FAU - Flouda, Sofia
AU  - Flouda S
AD  - Rheumatology and Clinical Immunology Unit, 4 Department of Internal Medicine, 
      "Attikon" University Hospital of Athens, Greece.
FAU - Chavatza, Aikaterina
AU  - Chavatza A
AD  - Rheumatology and Clinical Immunology Unit, 4 Department of Internal Medicine, 
      "Attikon" University Hospital of Athens, Greece.
FAU - Nikolopoulos, Dionisios
AU  - Nikolopoulos D
AD  - Rheumatology and Clinical Immunology Unit, 4 Department of Internal Medicine, 
      "Attikon" University Hospital of Athens, Greece.
FAU - Pieta, Antigone
AU  - Pieta A
AD  - Rheumatology and Clinical Immunology Unit, 4 Department of Internal Medicine, 
      "Attikon" University Hospital of Athens, Greece.
FAU - Tseronis, Dimitrios
AU  - Tseronis D
AD  - Rheumatology and Clinical Immunology Unit, 4 Department of Internal Medicine, 
      "Attikon" University Hospital of Athens, Greece.
FAU - Aggelakos, Michail
AU  - Aggelakos M
AD  - Rheumatology and Clinical Immunology Unit, 4 Department of Internal Medicine, 
      "Attikon" University Hospital of Athens, Greece.
FAU - Kassara, Dimitra
AU  - Kassara D
AD  - Rheumatology and Clinical Immunology Unit, 4 Department of Internal Medicine, 
      "Attikon" University Hospital of Athens, Greece.
FAU - Tzavara, Vasiliki
AU  - Tzavara V
AD  - Department of Internal Medicine, General Hospital Korgialenio-Benakio HRC, 
      Athens, Greece.
FAU - Katsimbri, Pelagia
AU  - Katsimbri P
AD  - Rheumatology and Clinical Immunology Unit, 4 Department of Internal Medicine, 
      "Attikon" University Hospital of Athens, Greece.
FAU - Boumpas, Dimitrios
AU  - Boumpas D
AD  - Rheumatology and Clinical Immunology Unit, 4 Department of Internal Medicine, 
      "Attikon" University Hospital of Athens, Greece.
FAU - Karageorgas, Theofanis
AU  - Karageorgas T
AD  - Rheumatology and Clinical Immunology Unit, 4 Department of Internal Medicine, 
      "Attikon" University Hospital of Athens, Greece.
LA  - eng
PT  - Journal Article
DEP - 20200930
PL  - Greece
TA  - Mediterr J Rheumatol
JT  - Mediterranean journal of rheumatology
JID - 101730166
PMC - PMC7641027
OTO - NOTNLM
OT  - Interstitial lung diseases
OT  - connective tissue diseases
OT  - interstitial pneumonia with autoimmune features
OT  - pulmonary fibrosis
EDAT- 2020/11/10 06:00
MHDA- 2020/11/10 06:01
PMCR- 2020/09/30
CRDT- 2020/11/09 05:35
PHST- 2020/05/13 00:00 [received]
PHST- 2020/06/21 00:00 [revised]
PHST- 2020/07/01 00:00 [accepted]
PHST- 2020/11/09 05:35 [entrez]
PHST- 2020/11/10 06:00 [pubmed]
PHST- 2020/11/10 06:01 [medline]
PHST- 2020/09/30 00:00 [pmc-release]
AID - MJR-31-3-330 [pii]
AID - 10.31138/mjr.31.3.330 [doi]
PST - epublish
SO  - Mediterr J Rheumatol. 2020 Sep 30;31(3):330-336. doi: 10.31138/mjr.31.3.330. 
      eCollection 2020 Sep.