PMID- 33164543
OWN - NLM
STAT- MEDLINE
DCOM- 20210119
LR  - 20210119
IS  - 0006-9248 (Print)
IS  - 0006-9248 (Linking)
VI  - 121
IP  - 11
DP  - 2020
TI  - The probable role of insulin resistance and SIRT1 proteins in the Alzheimer's 
      disease.
PG  - 812-816
LID - 10.4149/BLL_2020_133 [doi]
AB  - OBJECTIVE: Recent evidence suggests that insulin resistance may play an important 
      role in the pathogenesis of Alzheimer's disease (AD). In this study, the probable 
      role of insulin resistance in the pathogenesis of AD was investigated in patients 
      with Type 2 Diabetes Mellitus (T2DM). METHODS: Serum amyloid beta (Abeta) (1-42), 
      insulin like growth factor-1 (IGF-1), sirtuin1 (SIRT1) and leptin protein levels 
      were measured in serum samples of control (n = 26), probable AD (n = 26), and 
      probable AD+T2DM patients (n = 12) using ELISA method. Mini mental state 
      examination (MMSE) was performed to the patient and control groups. RESULT: Serum 
      IGF-1 significantly increased in the probable AD+T2DM group as compared to the 
      control and probable AD groups (p < 0.05). The levels of serum leptin 
      significantly decreased in the probable AD and AD+T2DM groups as compared to the 
      control (p < 0.05). There were no statistically significant differences in serum 
      Abeta (1-42) and SIRT1 levels among groups (p > 0.05). CONCLUSION: The significant 
      decrease in serum leptin levels in AD patients may indicate that it may be a 
      therapeutic marker in AD. The level of serum Abeta peptide and SIRT1 proteins can 
      vary depending on the stage of the disease. Therefore, this study should be 
      supported by more comprehensive studies in terms of the number of patients in 
      advanced stage (Tab. 1, Fig. 4, Ref. 29).
FAU - Tural, R
AU  - Tural R
FAU - Altan, N
AU  - Altan N
FAU - Irkec, C
AU  - Irkec C
FAU - Sahin, D
AU  - Sahin D
FAU - Batur Caglayan, H Z
AU  - Batur Caglayan HZ
LA  - eng
PT  - Journal Article
PL  - Slovakia
TA  - Bratisl Lek Listy
JT  - Bratislavske lekarske listy
JID - 0065324
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Leptin)
RN  - EC 3.5.1.- (SIRT1 protein, human)
RN  - EC 3.5.1.- (Sirtuin 1)
SB  - IM
MH  - Alzheimer Disease/*blood
MH  - Amyloid beta-Peptides/*blood
MH  - Diabetes Mellitus, Type 2
MH  - Humans
MH  - *Insulin Resistance
MH  - Leptin/*blood
MH  - Sirtuin 1/*blood
OTO - NOTNLM
OT  - Alzheimer disease
OT  - IGF-1
OT  - amyloid beta (Abeta)
OT  - diabetes mellitus
OT  - insulin
OT  - sirtuin 1 (SIRT1) leptin.
EDAT- 2020/11/10 06:00
MHDA- 2021/01/20 06:00
CRDT- 2020/11/09 13:48
PHST- 2020/11/09 13:48 [entrez]
PHST- 2020/11/10 06:00 [pubmed]
PHST- 2021/01/20 06:00 [medline]
AID - 10.4149/BLL_2020_133 [doi]
PST - ppublish
SO  - Bratisl Lek Listy. 2020;121(11):812-816. doi: 10.4149/BLL_2020_133.