PMID- 33166187
OWN - NLM
STAT- MEDLINE
DCOM- 20210208
LR  - 20210208
IS  - 1522-1555 (Electronic)
IS  - 0193-1849 (Linking)
VI  - 320
IP  - 1
DP  - 2021 Jan 1
TI  - Alterations of gut microbiome in patients with type 2 diabetes mellitus who had 
      undergone cholecystectomy.
PG  - E113-E121
LID - 10.1152/ajpendo.00471.2020 [doi]
AB  - Patients with type 2 diabetes mellitus (T2DM) have a high risk of developing 
      cholecystic disease. The gut microbiota has been shown to be strongly associated 
      with cholecystectomy and T2DM pathogenesis. However, alterations of the gut 
      microbiome in patients with T2DM who had undergone cholecystectomy remain 
      unexplored. In this study, the gut microbiomes of 14 long-term patients with T2DM 
      who had undergone cholecystectomy (T2DIIC group) and 21 age- and/or sex-matched 
      subjects with new-onset (T2DI group) and long-term (T2DII group) T2DM without 
      cholecystectomy were assessed using 16S rRNA gene sequencing of stool samples. It 
      was found that cholecystectomy could alleviate the decrease in Pielou's evenness 
      and the increase in the relative abundances of the Firmicutes phylum and 
      Lachnospira genus in long-term patients with T2DM compared with T2DII subjects. 
      Moreover, cholecystectomy also significantly increased the relative abundance of 
      the Fusobacteria phylum, as well as that of the Fusobacterium and Bilophila 
      genera. Interestingly, the T2DIIC and T2DI groups showed higher similarities than 
      the T2DII group with respect to patterns of gut microbiota composition and 
      predicted gut metagenomes. In summary, cholecystectomy could partially alleviate 
      long-term diabetes-induced dysbiosis of the gut microbiota composition and 
      function, but alterations in T2DM patient health warrant further study.NEW & 
      NOTEWORTHY The gut microbiome of long-term T2DM patients who had undergone 
      cholecystectomy and age- and/or sex-matched subjects of new-onset and long-term 
      T2DM without cholecystectomy was assessed using 16S rRNA gene sequencing in stool 
      samples. The findings suggest that, cholecystectomy could partially alleviate 
      long-term diabetes-induced dysbiosis of gut microbiome composition and function.
FAU - Wei, Bin
AU  - Wei B
AD  - College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze 
      River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, 
      Hangzhou, China.
FAU - Wang, Yakun
AU  - Wang Y
AD  - College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze 
      River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, 
      Hangzhou, China.
FAU - Xiang, Shoukui
AU  - Xiang S
AD  - Department of Endocrinology, The Third Affiliated Hospital of Soochow University, 
      Changzhou, China.
FAU - Jiang, Yan
AU  - Jiang Y
AD  - Department of Pharmacy, The Third Affiliated Hospital of Soochow University, 
      Changzhou, China.
FAU - Chen, Rong
AU  - Chen R
AD  - Department of Pharmacy, The Third Affiliated Hospital of Soochow University, 
      Changzhou, China.
FAU - Hu, Nan
AU  - Hu N
AD  - Department of Pharmacy, The Third Affiliated Hospital of Soochow University, 
      Changzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201109
PL  - United States
TA  - Am J Physiol Endocrinol Metab
JT  - American journal of physiology. Endocrinology and metabolism
JID - 100901226
RN  - 0 (RNA, Ribosomal, 16S)
RN  - 9002-71-5 (Thyrotropin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bilophila
MH  - *Cholecystectomy
MH  - Computational Biology
MH  - Diabetes Mellitus, Type 2/*microbiology
MH  - Feces/microbiology
MH  - Female
MH  - Fusobacterium
MH  - *Gastrointestinal Microbiome
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Postoperative Period
MH  - RNA, Ribosomal, 16S/metabolism
MH  - Thyrotropin/pharmacology
OTO - NOTNLM
OT  - 16S rRNA sequencing
OT  - cholecystectomy
OT  - gut microbiome
OT  - long-term type 2 diabetes
OT  - new-onset type 2 diabetes
EDAT- 2020/11/10 06:00
MHDA- 2021/02/09 06:00
CRDT- 2020/11/09 17:10
PHST- 2020/11/10 06:00 [pubmed]
PHST- 2021/02/09 06:00 [medline]
PHST- 2020/11/09 17:10 [entrez]
AID - 10.1152/ajpendo.00471.2020 [doi]
PST - ppublish
SO  - Am J Physiol Endocrinol Metab. 2021 Jan 1;320(1):E113-E121. doi: 
      10.1152/ajpendo.00471.2020. Epub 2020 Nov 9.