PMID- 33166827 OWN - NLM STAT- MEDLINE DCOM- 20210615 LR - 20210615 IS - 1878-5506 (Electronic) IS - 1389-9457 (Linking) VI - 76 DP - 2020 Dec TI - Validation of the Brazilian Portuguese version of the narcolepsy severity scale. PG - 134-139 LID - S1389-9457(20)30472-X [pii] LID - 10.1016/j.sleep.2020.10.016 [doi] AB - INTRODUCTION: Narcolepsy type 1 is a sleep disorder and the most common cause of hypersonia of central origin. It is characterized by sleep attacks, cataplexy, sleep-related hallucinations, sleep paralysis and sleep fragmentation in a pleomorphic presentation. The Narcolepsy Severity Scale (NSS), questionnaire which assesses the frequency and impact of the main symptoms of narcolepsy was developed in order to determine its clinical severity, needing translation, cultural adaptation and validation in many languages. The objective is to validate the Brazilian Portuguese version of the NSS. METHODS: The Brazilian version of the NSS was translated to Brazilian Portuguese and applied to patients with a diagnosis of narcolepsy type 1 at the Daytime Excessive Sleepiness Service, at Psychobiology Department of the Universidade Federal de Sao Paulo (UNIFESP) between February 2018 and July 2019. RESULTS: A total of 52 patients completed the questionnaire. Cultural adaptations were made to better comprehension of patients. The Brazilian version of the NSS showed high internal consistency, demonstrated by the Cronbach's alpha coefficient of 0.82. It showed good reproducibility capacity, verified through the test-retest, whose intraclass correlation was 0.98. The average severity of Brazilian patients was 33.94 (+/-11.24), higher than the values found in other population, which also underwent validation of this scale. There was a correlation between sleep latency in diagnostic polysomnography and the NSS. CONCLUSIONS: The Brazilian Portuguese version of NSS showed to be valid and reproducible tool for assessing the severity of patients with type 1 narcolepsy and have potential impact on clinical practice. CI - Copyright (c) 2020 Elsevier B.V. All rights reserved. FAU - Pimentel Filho, Lucio Huebra AU - Pimentel Filho LH AD - Departamento de Psicobiologia, Universidade Federal de Sao Paulo, Brazil. FAU - Gomes, Ana Carolina Dias AU - Gomes ACD AD - Departamento de Psicobiologia, Universidade Federal de Sao Paulo, Brazil. FAU - Frange, Cristina AU - Frange C AD - Departamento de Neurologia e Neurocirurgia, Universidade Federal de Sao Paulo, Sao Paulo, Brazil. FAU - Tufik, Sergio AU - Tufik S AD - Departamento de Psicobiologia, Universidade Federal de Sao Paulo, Brazil. FAU - Coelho, Fernando Morgadinho Santos AU - Coelho FMS AD - Departamento de Psicobiologia, Universidade Federal de Sao Paulo, Brazil; Departamento de Neurologia e Neurocirurgia, Universidade Federal de Sao Paulo, Sao Paulo, Brazil. Electronic address: fernandomorgadinho@hotmail.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20201017 PL - Netherlands TA - Sleep Med JT - Sleep medicine JID - 100898759 SB - IM MH - Brazil MH - Humans MH - Language MH - *Narcolepsy/diagnosis MH - Reproducibility of Results MH - *Surveys and Questionnaires MH - Translations OTO - NOTNLM OT - Narcolepsy OT - Psychometric OT - Questionnaire OT - Sleep OT - Symptom evaluation OT - Validity EDAT- 2020/11/10 06:00 MHDA- 2021/06/16 06:00 CRDT- 2020/11/09 20:17 PHST- 2020/08/15 00:00 [received] PHST- 2020/09/22 00:00 [revised] PHST- 2020/10/16 00:00 [accepted] PHST- 2020/11/10 06:00 [pubmed] PHST- 2021/06/16 06:00 [medline] PHST- 2020/11/09 20:17 [entrez] AID - S1389-9457(20)30472-X [pii] AID - 10.1016/j.sleep.2020.10.016 [doi] PST - ppublish SO - Sleep Med. 2020 Dec;76:134-139. doi: 10.1016/j.sleep.2020.10.016. Epub 2020 Oct 17.