PMID- 33171381
OWN - NLM
STAT- MEDLINE
DCOM- 20210108
LR  - 20240330
IS  - 1724-191X (Electronic)
IS  - 1120-1797 (Print)
IS  - 1120-1797 (Linking)
VI  - 80
DP  - 2020 Dec
TI  - Dosimetric and radiation cancer risk evaluation of high resolution thorax CT 
      during COVID-19 outbreak.
PG  - 119-124
LID - S1120-1797(20)30261-1 [pii]
LID - 10.1016/j.ejmp.2020.10.018 [doi]
AB  - PURPOSE: The aim of this work was to evaluate the dosimetric impact of 
      high-resolution thorax CT during COVID-19 outbreak in the University Hospital of 
      Parma. In two months we have performed a huge number of thorax CT scans 
      collecting effective and equivalent organ doses and evaluating also the lifetime 
      attributable risk (LAR) of lung and other major cancers. MATERIALS AND METHOD: 
      From February 24th to April 28th, 3224 high-resolution thorax CT were acquired. 
      For all patients we have examined the volumetric computed tomography dose index 
      (CTDIvol), the dose length product (DLP), the size-specific dose estimate (SSDE) 
      and effective dose (E(103)) using a dose tracking software (Radimetrics Bayer 
      HealthCare). From the equivalent dose to organs for each patient, LAR for lung 
      and major cancers were estimated following the method proposed in BEIR VII which 
      considers age and sex differences. RESULTS: Study population included 3224 
      patients, 1843 male and 1381 female, with an average age of 67 years. The average 
      CTDIvol, SSDE and DLP, and E(103) were 6.8 mGy, 8.7 mGy, 239 mGy.cm and 4.4 mSv 
      respectively. The average LAR of all solid cancers was 2.1 cases per 10,000 
      patients, while the average LAR of leukemia was 0.2 cases per 10,000 patients. 
      For both male and female the organ with a major cancer risk was lung. 
      CONCLUSIONS: Despite the impressive increment in thoracic CT examinations due to 
      COVID-19 outbreak, the high resolution low dose protocol used in our hospital 
      guaranteed low doses and very low risk estimation in terms of LAR.
CI  - Copyright (c) 2020 Associazione Italiana di Fisica Medica. Published by Elsevier 
      Ltd. All rights reserved.
FAU - Ghetti, C
AU  - Ghetti C
AD  - Department of Medical Physics, University Hospital of Parma, Italy.
FAU - Ortenzia, O
AU  - Ortenzia O
AD  - Department of Medical Physics, University Hospital of Parma, Italy. Electronic 
      address: oortenzia@ao.pr.it.
FAU - Maddalo, M
AU  - Maddalo M
AD  - Department of Medical Physics, University Hospital of Parma, Italy.
FAU - Altabella, L
AU  - Altabella L
AD  - Department of Medical Physics, University Hospital of Parma, Italy.
FAU - Sverzellati, N
AU  - Sverzellati N
AD  - Department of Medicine and Surgery, Division of Radiology, University of Parma, 
      Italy.
LA  - eng
PT  - Journal Article
DEP - 20201031
PL  - Italy
TA  - Phys Med
JT  - Physica medica : PM : an international journal devoted to the applications of 
      physics to medicine and biology : official journal of the Italian Association of 
      Biomedical Physics (AIFB)
JID - 9302888
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - COVID-19/*epidemiology
MH  - Disease Outbreaks
MH  - Female
MH  - Humans
MH  - Lung/radiation effects
MH  - Male
MH  - Middle Aged
MH  - Models, Statistical
MH  - Neoplasms, Radiation-Induced/*etiology
MH  - Radiation Dosage
MH  - Radiometry/*methods
MH  - Risk Assessment
MH  - Sex Factors
MH  - Software
MH  - Thorax/*diagnostic imaging
MH  - Tomography, X-Ray Computed/*adverse effects
PMC - PMC7604119
OTO - NOTNLM
OT  - COVID-19
OT  - CT dosimetry
OT  - Dose tracking
OT  - Lifetime attributable risk
OT  - Thorax imaging
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2020/11/11 06:00
MHDA- 2021/01/09 06:00
PMCR- 2020/10/31
CRDT- 2020/11/10 20:12
PHST- 2020/05/14 00:00 [received]
PHST- 2020/08/12 00:00 [revised]
PHST- 2020/10/22 00:00 [accepted]
PHST- 2020/11/11 06:00 [pubmed]
PHST- 2021/01/09 06:00 [medline]
PHST- 2020/11/10 20:12 [entrez]
PHST- 2020/10/31 00:00 [pmc-release]
AID - S1120-1797(20)30261-1 [pii]
AID - 10.1016/j.ejmp.2020.10.018 [doi]
PST - ppublish
SO  - Phys Med. 2020 Dec;80:119-124. doi: 10.1016/j.ejmp.2020.10.018. Epub 2020 Oct 31.